BARD1 Proteine (BARD1)

Bezeichnung:
BRCA1 Associated RING Domain 1 Proteine (BARD1)
Auf www.antikoerper-online.de finden Sie aktuell 4 BRCA1 Associated RING Domain 1 (BARD1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BARD1 Antikörper (83) und BARD1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 94 BARD1 Produkte verfügbar.
Synonyme:
BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913
alle Proteine anzeigen Gen GeneID UniProt
BARD1 580 Q99728
BARD1 12021 O70445
BARD1 64557 Q9QZH2

Weitere Synonyme anzeigen

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Human BRCA1 Associated RING Domain 1 (BARD1) Interaktionspartner

  1. NPM1 (zeige NPM1 Proteine) downregulation by P-STAT5 (zeige STAT5A Proteine) is mediated by impairing the BRCA1-BARD1 ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Proteine). In turn, decreased NPM1 (zeige NPM1 Proteine) levels led to suppression of p53 (zeige TP53 Proteine) expression, resulting in enhanced cell survival.

  2. In MCF-7 cells BARD1 variants do vary considerably their cellular distribution and in their ability to influence apoptotic response to cisplatin.

  3. substitutions that create a structurally intact BRCA1/BARD1 heterodimer that is inactive in vitro with all E2 enzymes. Other substitutions in BRCA1 or BARD1 RING domains result in hyperactivity, revealing that both proteins have evolved attenuated activity. Loss of attenuation results in decreased product specificity, providing a rationale for why nature has tuned BRCA1 activity.

  4. Findings suggest that the study of AtROW1 in plant may provide a model for elucidating the functional mechanism of BARD1 in mammals.

  5. BRCA1-BARD1 ligase activity and subsequent SMARCAD1 (zeige SMARCAD1 Proteine)-dependent chromatin remodeling are critical regulators of DNA repair in cancer cells.

  6. Results suggest that BRCA1-associated RING domain protein 1 (BARD1) rs7585356 G>A polymorphism may be associated with nephroblastoma risk.

  7. BARD1 rs6435862 T>G and rs3768716 A>G single nucleotide polymorphisms contribute to increased susceptibility to neuroblastoma (zeige ARHGEF16 Proteine), especially for children at age >/=12 months in a Southern Chinese population.

  8. BRCA pathway germline mutation (in BRCA1, BRCA2 (zeige BRCA2 Proteine) or BARD1 genes) was present in 10 of the 42 investigated triple-negative breast cancer patients rendering them susceptible to homologous recombination deficiency.

  9. Study presents four different pathogenic BARD1 variants identified in ovarian cancer patients. Three of them result in incorrect splicing of the corresponding exons, which may prompt expression of specific BARD1 isoforms and carcinogenesis.

  10. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

Mouse (Murine) BRCA1 Associated RING Domain 1 (BARD1) Interaktionspartner

  1. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

  2. identification of BARD1 as mediator between proapoptotic stress and p53 (zeige TP53 Proteine)-dependent apoptosis

  3. the developmental functions of Brca1 (zeige BRCA1 Proteine) and Bard1 are mediated by the Brca1 (zeige BRCA1 Proteine)/Bard1 heterodimer.

  4. Data show that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in a homologous-repair deficiency.

  5. the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and homology-directed DNA repair.

  6. The remarkable similarities between the mammary carcinomas of Bard1-, Brca1 (zeige BRCA1 Proteine)-, and Bard1/Brca1 (zeige BRCA1 Proteine)-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1 (zeige BRCA1 Proteine)/BARD1 heterodimer.

BARD1 Protein Überblick

Protein Überblick

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Alternative names and synonyms associated with BARD1

  • BRCA1 associated RING domain 1 (BARD1)
  • novel protein similar to vertebrate BRCA1 associated RING domain 1 (BARD1) (CH211-207D8.3)
  • BRCA1 associated RING domain 1 (LOC100229796)
  • BRCA1 associated RING domain 1 (bard1)
  • BRCA1 associated RING domain 1 (Bard1)
  • BARD1 Protein
  • ENSMUSG00000060893 Protein
  • ENSMUSG00000073653 Protein
  • LOC100147913 Protein

Bezeichner auf Proteinebene für BARD1

BRCA1 associated RING domain 1 , BRCA1-associated RING domain protein 1-like , BRCA1 associated RING domain 1 isoform alfa , BRCA1 associated RING domain 1 isoform beta , BRCA1 associated RING domain 1 isoform delta , BRCA1 associated RING domain 1 isoform epsilon , BRCA1 associated RING domain 1 isoform eta , BRCA1 associated RING domain 1 isoform gamma , BRCA1 associated RING domain 1 isoform phi , BRCA1-associated RING domain gene 1 , BRCA1-associated RING domain protein 1 , BARD-1

GENE ID SPEZIES
100053962 Equus caballus
470638 Pan troglodytes
694301 Macaca mulatta
100147913 Danio rerio
100229796 Taeniopygia guttata
100405252 Callithrix jacchus
100447274 Pongo abelii
100471907 Ailuropoda melanoleuca
100538376 Meleagris gallopavo
100563125 Anolis carolinensis
100600973 Nomascus leucogenys
580 Homo sapiens
424010 Gallus gallus
610190 Canis lupus familiaris
100156005 Sus scrofa
530961 Bos taurus
12021 Mus musculus
64557 Rattus norvegicus
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