anti-BARD1 (BARD1) Antikörper

Bezeichnung:
anti-BRCA1 Associated RING Domain 1 Antikörper (BARD1)
Auf www.antikoerper-online.de finden Sie aktuell 83 BRCA1 Associated RING Domain 1 (BARD1) Antikörper von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BARD1 Proteine (4) und BARD1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 94 BARD1 Produkte verfügbar.
Synonyme:
BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913

Meistgesuchte Reaktivitäten zu anti-BARD1 (BARD1) Antikörper

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anti-Human BARD1 Antikörper:

anti-Mouse (Murine) BARD1 Antikörper:

anti-Rat (Rattus) BARD1 Antikörper:

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Am meisten referenzierte anti-BARD1 Antikörper

  1. Human Polyclonal BARD1 Primary Antibody für IP, PLA - ABIN151785 : Hu, Ghosh, Amleh, Yue, Lu, Katz, Li: Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. in Oncogene 2005 (PubMed)
    Zeige alle 13 Referenzen für 151785

  2. Human Monoclonal BARD1 Primary Antibody für ELISA - ABIN395260 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010 (PubMed)
    Zeige alle 5 Referenzen für 395260

  3. Human Polyclonal BARD1 Primary Antibody für EIA, WB - ABIN950603 : Dizin, Irminger-Finger: Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1. in The international journal of biochemistry & cell biology 2010 (PubMed)
    Zeige alle 3 Referenzen für 950603

  4. Human Polyclonal BARD1 Primary Antibody für IHC, IHC (p) - ABIN4283035 : Jerjees, Alabdullah, Green, Alshareeda, Macmillan, Ellis, Rakha: Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer. in Breast cancer research and treatment 2014 (PubMed)
    Zeige alle 2 Referenzen für 4283035

  5. Human Polyclonal BARD1 Primary Antibody für IF (p), IHC (p) - ABIN706496 : Liu, Ao, Jia, Bai, Xu, Hu, Jiang, Chen, Wu: FOXK2 transcription factor suppresses ER?-positive breast cancer cell growth through down-regulating the stability of ER? via mechanism involving BRCA1/BARD1. in Scientific reports 2015 (PubMed)

  6. Human Polyclonal BARD1 Primary Antibody für WB - ABIN654621 : Irminger-Finger: BARD1, a possible biomarker for breast and ovarian cancer. in Gynecologic oncology 2010 (PubMed)

  7. Human Polyclonal BARD1 Primary Antibody für ELISA, WB - ABIN1534425 : Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005 (PubMed)

Weitere Antikörper gegen BARD1 Interaktionspartner

Human BRCA1 Associated RING Domain 1 (BARD1) Interaktionspartner

  1. NPM1 (zeige NPM1 Antikörper) downregulation by P-STAT5 (zeige STAT5A Antikörper) is mediated by impairing the BRCA1-BARD1 ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Antikörper). In turn, decreased NPM1 (zeige NPM1 Antikörper) levels led to suppression of p53 (zeige TP53 Antikörper) expression, resulting in enhanced cell survival.

  2. In MCF-7 cells BARD1 variants do vary considerably their cellular distribution and in their ability to influence apoptotic response to cisplatin.

  3. substitutions that create a structurally intact BRCA1/BARD1 heterodimer that is inactive in vitro with all E2 enzymes. Other substitutions in BRCA1 or BARD1 RING domains result in hyperactivity, revealing that both proteins have evolved attenuated activity. Loss of attenuation results in decreased product specificity, providing a rationale for why nature has tuned BRCA1 activity.

  4. Findings suggest that the study of AtROW1 in plant may provide a model for elucidating the functional mechanism of BARD1 in mammals.

  5. BRCA1-BARD1 ligase activity and subsequent SMARCAD1 (zeige SMARCAD1 Antikörper)-dependent chromatin remodeling are critical regulators of DNA repair in cancer cells.

  6. Results suggest that BRCA1-associated RING domain protein 1 (BARD1) rs7585356 G>A polymorphism may be associated with nephroblastoma risk.

  7. BARD1 rs6435862 T>G and rs3768716 A>G single nucleotide polymorphisms contribute to increased susceptibility to neuroblastoma (zeige ARHGEF16 Antikörper), especially for children at age >/=12 months in a Southern Chinese population.

  8. BRCA pathway germline mutation (in BRCA1, BRCA2 (zeige BRCA2 Antikörper) or BARD1 genes) was present in 10 of the 42 investigated triple-negative breast cancer patients rendering them susceptible to homologous recombination deficiency.

  9. Study presents four different pathogenic BARD1 variants identified in ovarian cancer patients. Three of them result in incorrect splicing of the corresponding exons, which may prompt expression of specific BARD1 isoforms and carcinogenesis.

  10. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

Mouse (Murine) BRCA1 Associated RING Domain 1 (BARD1) Interaktionspartner

  1. Suggest BARD1 as a driver of proliferation and of pulmonary fibrosis pathogenesis.

  2. identification of BARD1 as mediator between proapoptotic stress and p53 (zeige TP53 Antikörper)-dependent apoptosis

  3. the developmental functions of Brca1 (zeige BRCA1 Antikörper) and Bard1 are mediated by the Brca1 (zeige BRCA1 Antikörper)/Bard1 heterodimer.

  4. Data show that expression of truncated mouse or human BARD1 peptides capable of interacting with Brca1 results in a homologous-repair deficiency.

  5. the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and homology-directed DNA repair.

  6. The remarkable similarities between the mammary carcinomas of Bard1-, Brca1 (zeige BRCA1 Antikörper)-, and Bard1/Brca1 (zeige BRCA1 Antikörper)-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1 (zeige BRCA1 Antikörper)/BARD1 heterodimer.

BARD1 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Alternative names and synonyms associated with BARD1

  • BRCA1 associated RING domain 1 (BARD1) Antikörper
  • novel protein similar to vertebrate BRCA1 associated RING domain 1 (BARD1) (CH211-207D8.3) Antikörper
  • BRCA1 associated RING domain 1 (LOC100229796) Antikörper
  • BRCA1 associated RING domain 1 (bard1) Antikörper
  • BRCA1 associated RING domain 1 (Bard1) Antikörper
  • BARD1 Antikörper
  • ENSMUSG00000060893 Antikörper
  • ENSMUSG00000073653 Antikörper
  • LOC100147913 Antikörper

Bezeichner auf Proteinebene für BARD1

BRCA1 associated RING domain 1 , BRCA1-associated RING domain protein 1-like , BRCA1 associated RING domain 1 isoform alfa , BRCA1 associated RING domain 1 isoform beta , BRCA1 associated RING domain 1 isoform delta , BRCA1 associated RING domain 1 isoform epsilon , BRCA1 associated RING domain 1 isoform eta , BRCA1 associated RING domain 1 isoform gamma , BRCA1 associated RING domain 1 isoform phi , BRCA1-associated RING domain gene 1 , BRCA1-associated RING domain protein 1 , BARD-1

GENE ID SPEZIES
100053962 Equus caballus
470638 Pan troglodytes
694301 Macaca mulatta
100147913 Danio rerio
100229796 Taeniopygia guttata
100405252 Callithrix jacchus
100447274 Pongo abelii
100471907 Ailuropoda melanoleuca
100538376 Meleagris gallopavo
100563125 Anolis carolinensis
100600973 Nomascus leucogenys
580 Homo sapiens
424010 Gallus gallus
610190 Canis lupus familiaris
100156005 Sus scrofa
530961 Bos taurus
12021 Mus musculus
64557 Rattus norvegicus
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