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APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Proteine (APEX1)

Bezeichnung:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Proteine (APEX1)
Auf www.antikoerper-online.de finden Sie aktuell 33 APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Antikörper (186) und APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Kits (15) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 250 APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Produkte verfügbar.
Synonyme:
APE, APE1, APEN, Apex, apex1, apex1a, APX, BAP1, HAP1, hm:zehn1532, MGC76280, MGC78928, MGC79645, Ref-1, REF1, wu:fc13d11, zgc:66204
alle Proteine anzeigen Gen GeneID UniProt
APEX1 328 P27695
APEX1 79116 P43138
APEX1 11792 P28352

Weitere Synonyme anzeigen

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Am meisten referenzierte APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Proteine

  1. Human APEX1 Protein expressed in Escherichia coli (E. coli) - ABIN667332 : Hinz, Wang, Smerdon: Base excision repair in a glucocorticoid response element: effect of glucocorticoid receptor binding. in The Journal of biological chemistry 2010 (PubMed)
    Zeige alle 2 Referenzen für ABIN667332

  2. Human APEX1 Protein expressed in Escherichia coli (E. coli) - ABIN2005187 : Kogai, Taki, Brent: Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. in Endocrine-related cancer 2006 (PubMed)

  3. Human APEX1 Protein expressed in Wheat germ - ABIN1345305 : Zhao, Gao, Zhang, Wei, Liu, Deng: Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity. in The Journal of biological chemistry 2008 (PubMed)

Weitere Proteine zu APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Interaktionspartnern

Human APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. APE1 acetylation is an integral part of the base excision repair pathway for maintaining genomic integrity.

  2. Effects of monovalent (K(+)) and divalent (Mg(2 (zeige MUC7 Proteine)+), Mn(2+), Ca(2 (zeige CA2 Proteine)+), Zn(2+), Cu(2+), and Ni(2 (zeige VMP1 Proteine)+)) metal ions on DNA binding and catalytic stages of APEX1 were studied.

  3. APE1 Accelerates turnover of OGG1 (zeige OGG1 Proteine) by preventing retrograde binding to the abasic-site product.

  4. The results demonstrate a crucial role of APE1 3' to 5' exonuclease (zeige EXO1 Proteine) activity in combating mutations in CpG clusters caused by an intermediate of DNA demethylation during base excision repair.

  5. In an in vivo model of restenosis, which is characterized by oxidative stress, endothelial activation, and smooth muscle cell proliferation, Thioredoxin-1 protein levels are reduced in the endothelium of the carotids. APEX1 acts anti-apoptotic in endothelial cells. This anti-apoptotic effect depends on the first 20 amino acids of APEX1

  6. While DNA conformational alteration is negligible, APE1 enzyme shows characteristic changes in the alpha helix and beta strand ratio after incubation with G. lucidum extract. The enhanced reactivity of APE1 at the molecular level in the presence of G. lucidium is attributed to this effect.

  7. These results strongly indicate that anti-inflammatory effects in TNF-alpha (zeige TNF Proteine)-stimulated endothelial cells by acetylation are tightly linked to secreted APE1/Ref-1, which inhibits TNF-alpha (zeige TNF Proteine) binding to TNFR1 (zeige TNFRSF1A Proteine) by reductive conformational change, with suggestion as an endogenous inhibitor of vascular inflammation.

  8. Polymorphism in XRCC1 (zeige XRCC1 Proteine) and APE1 gene is associated with an increased risk of COPD (zeige ARCN1 Proteine).

  9. Data indicate conserved amino acid residues in the nucleotide incision repair (NIR (zeige NOC2L Proteine))-specific enzymes of human APE1 and Bacillus subtilis ExoA..

  10. Based on these results, we conclude that the APEX gene polymorphism Ile64Val may be associated with an increased risk of colorectal cancer.

Pig (Porcine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. Study shows the methylation of the APE1 promoter and its role in mediating the functional effects of redox reactions induced by oxidative stress.

Cow (Bovine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. Meiosis progression and female age affect expression profile of DNA repair APEX1 gene in bovine oocytes.

  2. prediction of the 3D structure of bovine AP lyase (BAP1); models of mutants showed substitution of Arg176-->Ala leads to the loss of DNA binding whereas mutation of Asp282-->Ala and His308-->Asn leads to a decrease in the enzymatic activity.

Mouse (Murine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. Suppression of Ape1/Ref-1 redox function leads to an increased cell surface retention of IL-12 (zeige IL12A Proteine) and enhances Th1 (zeige HAND1 Proteine) responses.

  2. Is closely associated with upregulation of the Ref1 (zeige THOC4 Proteine)/Nrf2 (zeige NFE2L2 Proteine) signalling pathway.

  3. Results show the stimulatory effect of PARP-1 (zeige PARP1 Proteine) on APE1-dependent base excision repair (BER). PARP-1 (zeige PARP1 Proteine) and APE1 appear to have a functional interaction in BER since PARP-1 (zeige PARP1 Proteine) can stimulate the strand incision activity of APE1.

  4. increases in APEX1 level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  5. Endothelial cell tumor proliferation was found to be dependent on Apex-1 expression.

  6. Expression of OGG1 (zeige OGG1 Proteine) and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  7. Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR).

  8. These results suggest that mitochondrial APE1/Ref-1 is contributed to the protective role to protein kinase C-induced mitochondrial dysfunction in endothelial cells.

  9. Spinal motor neurones down-regulate APE1 upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

  10. The reductive activation of endothelial SIRT1 (zeige SIRT1 Proteine) by APE1/Ref-1 mediates the effect of APE1/Ref-1 on eNOS (zeige NOS3 Proteine) acetylation, promoting endothelium-derived NO and endothelium-dependent vasorelaxation.

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Protein Überblick

Protein Überblick

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\; all encode the same protein.

Alternative names and synonyms associated with APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)

  • APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1)
  • DNA-apurinic or apyrimidinic site lyase (apex1)
  • APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1)
  • DNA-(apurinic or apyrimidinic site) lyase (CNG03640)
  • DNA-(apurinic or apyrimidinic site) lyase (CNH01280)
  • DNA-(apurinic or apyrimidinic site) lyase (nth)
  • DNA-(apurinic or apyrimidinic site) lyase (Spirs_4119)
  • DNA-(apurinic or apyrimidinic site) lyase (Palpr_0103)
  • APEX nuclease (multifunctional DNA repair enzyme) 1 (Apex1)
  • apurinic/apyrimidinic endonuclease 1 (Apex1)
  • APE Protein
  • APE1 Protein
  • APEN Protein
  • Apex Protein
  • apex1 Protein
  • apex1a Protein
  • APX Protein
  • BAP1 Protein
  • HAP1 Protein
  • hm:zehn1532 Protein
  • MGC76280 Protein
  • MGC78928 Protein
  • MGC79645 Protein
  • Ref-1 Protein
  • REF1 Protein
  • wu:fc13d11 Protein
  • zgc:66204 Protein

Bezeichner auf Proteinebene für APEX1

DNA-(apurinic or apyrimidinic site) lyase , APEX nuclease 1 , APEX nuclease (multifunctional DNA repair enzyme) 1 , AP endonuclease class I , AP lyase , apurinic-apyrimidinic endonuclease 1 , apurinic/apyrimidinic (abasic) endonuclease , deoxyribonuclease (apurinic or apyrimidinic) , protein REF-1 , redox factor-1 , AP endonuclease 1 , APEN , apurinic/apyrimidinic endonuclease 1 , apurinic/apyrimidinic endonuclease , zap1 , Apurinic-apyrimidinic endonuclease 1 , Redox factor-1 , APEX nuclease

GENE ID SPEZIES
100431102 Gallus gallus
100196733 Salmo salar
394929 Xenopus (Silurana) tropicalis
432324 Xenopus laevis
3258636 Cryptococcus neoformans var. neoformans JEC21
3259293 Cryptococcus neoformans var. neoformans JEC21
4211673 Alcanivorax borkumensis SK2
9492248 Spirochaeta smaragdinae DSM 11293
9997717 Paludibacter propionicigenes WB4
328 Homo sapiens
79116 Rattus norvegicus
482558 Canis lupus familiaris
100154728 Sus scrofa
281630 Bos taurus
406730 Danio rerio
100987860 Pan paniscus
465200 Pan troglodytes
11792 Mus musculus
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