DNA Reparatur

Die DNA ist Träger der genetischen Information, durch die jedes Lebewesen definiert wird. Der in der DNA festgelegte genetische Code ist ein wesentlicher Bestandteil von Prozessen auf subzellulärer Ebene bis hin zur Erscheinung und Funktion des Organismus als Ganzes. Nichtsdestotrotz ist die DNA Gefahren durch endogene Quellen wie der Hydrolyse, Oxidation, Alkylierung oder Replikationsfehlern ausgesetzt. Hinzu kommen ionisierende Strahlung, UV-Strahlung und eine Reihe chemischer Reagenzien, die externe Gefahrenfaktoren für die Integrität der DNA bilden.

Anders als die RNA und Proteine, wird die DNA infolge von Beschädigungen nicht abgebaut und wieder synthetisiert. Stattdessen bestehen zahlreiche Reparatursignalwege, die sicherstellen, dass die DNA intakt bleibt. Francis Crick stellte im Jahr 1974 fest, dass „wir die mögliche Rolle von Enzymen bei der [DNA-]Reparatur vollständig außer Acht gelassen haben. Ich habe erst später festgestellt, dass die DNA so wertvoll ist, dass mehrere separate Mechanismen beteiligt sein könnten.“

Diese Vorahnung hat sich bestätigt: Mehr als 100 Gene wurden seitdem ermittelt, die an dem komplexen Netzwerk von DNA-Reparatursignalwegen beteiligt sind. DNA-Schäden können, je nach Art der Läsion, durch sechs unterschiedliche Signalwege repariert werden: Chemische Modifizierung, Nukleotid-Fehleinbau und Vernetzungen werden durch die direkte Reparatur (DR), Mismatch-Reparatur (MMR) oder die Nukleotidexzisionsreparatur behoben. Einzelstrangbrüche der DNA werden durch die Basenexzision repariert und hochmutagene Doppelstrangbrüche schließlich durch eine Reihe komplexer Signalwege auf Grundlage der homologen Rekombination (HR) mit dem Schwesterchromatid (in der S- oder G2-Phase des Zellzyklus) oder der nicht-homologen Endverknüpfung (non-homologous end-joining, NHEJ). In dem Fall, dass eine DNA-Läsion nicht rechtzeitig repariert werden kann, ermöglichen spezielle DNA-Polymerasen die Transläsionssynthese (TLS), wodurch die Verzögerung der DNA-Replikationsgabel verhindert wird. Mutationen, die Teile dieser Reparatursignalwege außer Fuktion setzen, können Krankheiten wie Xeroderma pigmentosum, Louis-Bar-Syndrom, Fanconi-Anämie sowie einer Veranlagung zu Krebs auslösen.

Weiterhin sind diese Reparaturmechanismen von hohem Interesse für den Ansatz der gezielten Genom-Editierung, der sich die zellulären DNA-Reparaturmechanismen zu Nutzen macht.

Pathway Abbildung als PDF speichern.

Canonical Non-Homologous End-Joining

PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide):

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].   More...

XRCC6 - X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining)):

Antigene in dieser Kategorie:
ATM (Ataxia Telangiectasia Mutated): ATM Antikörper ATM ELISA Kits ATM Proteine
TRIM29 (Tripartite Motif Containing 29): TRIM29 Antikörper TRIM29 ELISA Kits TRIM29 Proteine
ATR (Ataxia Telangiectasia and Rad3 Related): ATR Antikörper ATR ELISA Kits  
H2AFX - H2A Histone Family, Member X: H2AFX Antikörper H2AFX ELISA Kits H2AFX Proteine
XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4): XRCC4 Antikörper XRCC4 ELISA Kits XRCC4 Proteine
LIG4 - Ligase IV, DNA, ATP-Dependent: LIG4 Antikörper LIG4 ELISA Kits LIG4 Proteine
NHEJ1 - Nonhomologous End-Joining Factor 1: NHEJ1 Antikörper NHEJ1 ELISA Kits NHEJ1 Proteine
APTX - Aprataxin: APTX Antikörper APTX ELISA Kits APTX Proteine
APLF (Aprataxin and PNKP Like Factor): APLF Antikörper APLF ELISA Kits APLF Proteine
DCLRE1C (DNA Cross-Link Repair 1C): DCLRE1C Antikörper DCLRE1C ELISA Kits DCLRE1C Proteine
PNKP (Polynucleotide Kinase 3'-Phosphatase): PNKP Antikörper PNKP ELISA Kits PNKP Proteine
DNTT - Deoxynucleotidyltransferase, terminal: DNTT Antikörper DNTT ELISA Kits DNTT Proteine
POLL (Polymerase (DNA Directed), lambda): POLL Antikörper POLL ELISA Kits POLL Proteine
POLM - Polymerase (DNA Directed), mu: POLM Antikörper   POLM Proteine
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A Antikörper MRE11A ELISA Kits MRE11A Proteine
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 Antikörper RAD50 ELISA Kits RAD50 Proteine
NBN - Nibrin: NBN Antikörper NBN ELISA Kits NBN Proteine
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 Antikörper TP53BP1 ELISA Kits TP53BP1 Proteine

Microhomology-Mediated End-Joining

PARP1 (Poly (ADP-Ribose) Polymerase 1):

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery...   More...
Antigene in dieser Kategorie:
LIG3 (Ligase III, DNA, ATP-Dependent): LIG3 Antikörper LIG3 ELISA Kits LIG3 Proteine
LIG2 - Ligase II, DNA, ATP-Dependent:   LIG2 ELISA Kits  
PARP2 - Poly (ADP-Ribose) Polymerase 2: PARP2 Antikörper PARP2 ELISA Kits PARP2 Proteine
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 Antikörper LIG1 ELISA Kits LIG1 Proteine
ATM (Ataxia Telangiectasia Mutated): ATM Antikörper ATM ELISA Kits ATM Proteine
TRIM29 (Tripartite Motif Containing 29): TRIM29 Antikörper TRIM29 ELISA Kits TRIM29 Proteine
ATR (Ataxia Telangiectasia and Rad3 Related): ATR Antikörper ATR ELISA Kits  
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 Antikörper RBBP8 ELISA Kits RBBP8 Proteine
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A Antikörper MRE11A ELISA Kits MRE11A Proteine
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 Antikörper RAD50 ELISA Kits RAD50 Proteine
NBN - Nibrin: NBN Antikörper NBN ELISA Kits NBN Proteine
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 Antikörper RECQL2 ELISA Kits  

Homologous Recombination

RAD51 (DNA Repair Protein Homolog 1):

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of...   More...

BRCA1 (Breast Cancer 1):

BRCA2 (Breast Cancer 2, Early Onset):

Antigene in dieser Kategorie:
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE Antikörper    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 Antikörper POLE2 ELISA Kits POLE2 Proteine
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 Antikörper POLE3 ELISA Kits POLE3 Proteine
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 Antikörper POLE4 ELISA Kits POLE4 Proteine
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 Antikörper POLD1 ELISA Kits POLD1 Proteine
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 Antikörper POLD2 ELISA Kits POLD2 Proteine
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 Antikörper POLD3 ELISA Kits POLD3 Proteine
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 Antikörper POLD4 ELISA Kits POLD4 Proteine
ATM (Ataxia Telangiectasia Mutated): ATM Antikörper ATM ELISA Kits ATM Proteine
TRIM29 (Tripartite Motif Containing 29): TRIM29 Antikörper TRIM29 ELISA Kits TRIM29 Proteine
ATR (Ataxia Telangiectasia and Rad3 Related): ATR Antikörper ATR ELISA Kits  
Rad51B - RAD51 Homolog B (S. Cerevisiae): Rad51B Antikörper   Rad51B Proteine
RAD51C (RAD51 Homolog C (S. Cerevisiae)): RAD51C Antikörper RAD51C ELISA Kits RAD51C Proteine
XRCC2 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2): XRCC2 Antikörper XRCC2 ELISA Kits XRCC2 Proteine
XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3): XRCC3 Antikörper XRCC3 ELISA Kits XRCC3 Proteine
BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1): BRIP1 Antikörper BRIP1 ELISA Kits  
BARD1 (BRCA1 Associated RING Domain 1): BARD1 Antikörper BARD1 ELISA Kits BARD1 Proteine
RBBP8 - Retinoblastoma Binding Protein 8: RBBP8 Antikörper RBBP8 ELISA Kits RBBP8 Proteine
FAM175A - Family with Sequence Similarity 175, Member A: FAM175A Antikörper FAM175A ELISA Kits FAM175A Proteine
UIMC1 - Ubiquitin Interaction Motif Containing 1: UIMC1 Antikörper UIMC1 ELISA Kits UIMC1 Proteine
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A Antikörper MRE11A ELISA Kits MRE11A Proteine
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 Antikörper RAD50 ELISA Kits RAD50 Proteine
NBN - Nibrin: NBN Antikörper NBN ELISA Kits NBN Proteine
TP53BP1 (Tumor Protein P53 Binding Protein 1): TP53BP1 Antikörper TP53BP1 ELISA Kits TP53BP1 Proteine
RPA1 - Replication Protein A1, 70kDa: RPA1 Antikörper RPA1 ELISA Kits RPA1 Proteine
RPA2 (Replication Protein A2, 32kDa): RPA2 Antikörper RPA2 ELISA Kits RPA2 Proteine
RPA3 (Replication Protein A3, 14kDa): RPA3 Antikörper   RPA3 Proteine
PALB2 (Partner and Localizer of BRCA2): PALB2 Antikörper PALB2 ELISA Kits PALB2 Proteine
TOP3A (Topoisomerase (DNA) III alpha): TOP3A Antikörper TOP3A ELISA Kits  
RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1): RMI1 Antikörper RMI1 ELISA Kits RMI1 Proteine
RMI2 (RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae)): RMI2 Antikörper RMI2 ELISA Kits RMI2 Proteine
DNA2 (DNA Replication Helicase 2 Homolog (Yeast)): DNA2 Antikörper DNA2 ELISA Kits  
RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: RECQL2 Antikörper RECQL2 ELISA Kits  
RAD54L (RAD54-Like (S. Cerevisiae)): RAD54L Antikörper RAD54L ELISA Kits RAD54L Proteine
MUS81 (MUS81 Endonuclease Homolog (S. Cerevisiae)): MUS81 Antikörper MUS81 ELISA Kits MUS81 Proteine
SLX1B - SLX1 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae): SLX1B Antikörper SLX1B ELISA Kits SLX1B Proteine
BTBD12 - BTB (POZ) Domain Containing 12: BTBD12 Antikörper BTBD12 ELISA Kits  
GEN1 (Gen Endonuclease Homolog 1 (Drosophila)): GEN1 Antikörper    

Single Strand Annealing

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

ERCC1 (Excision Repair Cross Complementing Polypeptide-1):

Antigene in dieser Kategorie:
MSH3 (MutS Homolog 3 (E. Coli)): MSH3 Antikörper MSH3 ELISA Kits  
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 Antikörper ERCC4 ELISA Kits  
ATM (Ataxia Telangiectasia Mutated): ATM Antikörper ATM ELISA Kits ATM Proteine
TRIM29 (Tripartite Motif Containing 29): TRIM29 Antikörper TRIM29 ELISA Kits TRIM29 Proteine
ATR (Ataxia Telangiectasia and Rad3 Related): ATR Antikörper ATR ELISA Kits  
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A Antikörper MRE11A ELISA Kits MRE11A Proteine
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 Antikörper RAD50 ELISA Kits RAD50 Proteine
NBN - Nibrin: NBN Antikörper NBN ELISA Kits NBN Proteine
RPA1 - Replication Protein A1, 70kDa: RPA1 Antikörper RPA1 ELISA Kits RPA1 Proteine
RPA2 (Replication Protein A2, 32kDa): RPA2 Antikörper RPA2 ELISA Kits RPA2 Proteine
RPA3 (Replication Protein A3, 14kDa): RPA3 Antikörper   RPA3 Proteine
RAD52 (RAD52 Homolog (S. Cerevisiae)): RAD52 Antikörper RAD52 ELISA Kits RAD52 Proteine

Break-Induced Replication

MCM2 - Minichromosome Maintenance Complex Component 2

MCM7 - Minichromosome Maintenance Complex Component 7

Antigene in dieser Kategorie:
RAD51 (DNA Repair Protein Homolog 1): RAD51 Antikörper RAD51 ELISA Kits RAD51 Proteine
MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): MRE11A Antikörper MRE11A ELISA Kits MRE11A Proteine
RAD50 (RAD50 Homolog (S. Cerevisiae)): RAD50 Antikörper RAD50 ELISA Kits RAD50 Proteine
NBN - Nibrin: NBN Antikörper NBN ELISA Kits NBN Proteine
RPA1 - Replication Protein A1, 70kDa: RPA1 Antikörper RPA1 ELISA Kits RPA1 Proteine
RPA2 (Replication Protein A2, 32kDa): RPA2 Antikörper RPA2 ELISA Kits RPA2 Proteine
RPA3 (Replication Protein A3, 14kDa): RPA3 Antikörper   RPA3 Proteine
MCM3 (Minichromosome Maintenance Complex Component 3): MCM3 Antikörper MCM3 ELISA Kits MCM3 Proteine
MCM4 (Minichromosome Maintenance Deficient 4): MCM4 Antikörper MCM4 ELISA Kits MCM4 Proteine
MCM5 - Minichromosome Maintenance Complex Component 5: MCM5 Antikörper MCM5 ELISA Kits MCM5 Proteine
MCM6 - Minichromosome Maintenance Complex Component 6: MCM6 Antikörper MCM6 ELISA Kits MCM6 Proteine

Base Excision Repair

OGG1 (8-Oxoguanine DNA Glycosylase):

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the...   More...

UNG (Uracil-DNA Glycosylase):

APEX1 - APEX Nuclease (Multifunctional DNA Repair Enzyme) 1

Antigene in dieser Kategorie:
MPG - N-Methylpurine-DNA Glycosylase: MPG Antikörper MPG ELISA Kits MPG Proteine
SMUG1 - Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1: SMUG1 Antikörper SMUG1 ELISA Kits SMUG1 Proteine
TDG - Thymine-DNA Glycosylase: TDG Antikörper TDG ELISA Kits TDG Proteine
MBD4 (Methyl-CpG Binding Domain Protein 4): MBD4 Antikörper MBD4 ELISA Kits MBD4 Proteine
MUTYH - MutY Homolog (E. Coli): MUTYH Antikörper MUTYH ELISA Kits MUTYH Proteine
NEIL1 (Endonuclease VIII-Like 1): NEIL1 Antikörper NEIL1 ELISA Kits NEIL1 Proteine
NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)): NEIL2 Antikörper NEIL2 ELISA Kits NEIL2 Proteine
NEIL3 (Nei Endonuclease VIII-Like 3 (E. Coli)): NEIL3 Antikörper NEIL3 ELISA Kits NEIL3 Proteine
POLB (Polymerase (DNA Directed), beta): POLB Antikörper POLB ELISA Kits POLB Proteine
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 Antikörper POLD1 ELISA Kits POLD1 Proteine
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 Antikörper POLD2 ELISA Kits POLD2 Proteine
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 Antikörper POLD3 ELISA Kits POLD3 Proteine
POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): POLD4 Antikörper POLD4 ELISA Kits POLD4 Proteine
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 Antikörper FEN1 ELISA Kits FEN1 Proteine
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 Antikörper LIG1 ELISA Kits LIG1 Proteine

Nuleotide Excision Repair

POLR2B - Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008].   More...

XPC (Xeroderma Pigmentosum, Complementation Group C):

DDB1 (Damage Specific DNA Binding Protein 1):

Antigene in dieser Kategorie:
XPA (Xeroderma Pigmentosum, Complementation Group A): XPA Antikörper XPA ELISA Kits XPA Proteine
RAD23A (RAD23 Homolog A (S. Cerevisiae)): RAD23A Antikörper RAD23A ELISA Kits RAD23A Proteine
RAD23B - RAD23 Homolog B (S. Cerevisiae): RAD23B Antikörper RAD23B ELISA Kits RAD23B Proteine
CETN2 (Centrin, EF-Hand Protein, 2): CETN2 Antikörper CETN2 ELISA Kits CETN2 Proteine
DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa): DDB2 Antikörper DDB2 ELISA Kits DDB2 Proteine
ERCC1 (Excision Repair Cross Complementing Polypeptide-1): ERCC1 Antikörper ERCC1 ELISA Kits ERCC1 Proteine
ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2): ERCC2 Antikörper ERCC2 ELISA Kits ERCC2 Proteine
ERCC3 - DNA Repair Protein Complementing XP-B Cells: ERCC3 Antikörper ERCC3 ELISA Kits ERCC3 Proteine
GTF2H1 - General Transcription Factor IIH, Polypeptide 1, 62kDa: GTF2H1 Antikörper GTF2H1 ELISA Kits GTF2H1 Proteine
GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa): GTF2H4 Antikörper   GTF2H4 Proteine
GTF2H3 (General Transcription Factor IIH, Polypeptide 3, 34kD): GTF2H3 Antikörper GTF2H3 ELISA Kits GTF2H3 Proteine
GTF2H5 - General Transcription Factor IIH, Polypeptide 5: GTF2H5 Antikörper GTF2H5 ELISA Kits GTF2H5 Proteine
CDK7 (Cyclin-Dependent Kinase 7): CDK7 Antikörper CDK7 ELISA Kits CDK7 Proteine
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 Antikörper RFC1 ELISA Kits RFC1 Proteine
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 Antikörper RFC2 ELISA Kits RFC2 Proteine
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 Antikörper RFC3 ELISA Kits RFC3 Proteine
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 Antikörper RFC4 ELISA Kits RFC4 Proteine
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 Antikörper RFC5 ELISA Kits RFC5 Proteine
POLK - Polymerase (DNA Directed) kappa: POLK Antikörper POLK ELISA Kits POLK Proteine
ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: ERCC4 Antikörper ERCC4 ELISA Kits  
ERCC5 - DNA Repair Protein Complementing XP-G Cells: ERCC5 Antikörper ERCC5 ELISA Kits ERCC5 Proteine
ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6): ERCC6 Antikörper   ERCC6 Proteine
ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8): ERCC8 Antikörper ERCC8 ELISA Kits ERCC8 Proteine
POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): POLE Antikörper    
POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): POLE2 Antikörper POLE2 ELISA Kits POLE2 Proteine
POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): POLE3 Antikörper POLE3 ELISA Kits POLE3 Proteine
POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): POLE4 Antikörper POLE4 ELISA Kits POLE4 Proteine
PCNA (Proliferating Cell Nuclear Antigen): PCNA Antikörper PCNA ELISA Kits PCNA Proteine
XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1): XRCC1 Antikörper XRCC1 ELISA Kits XRCC1 Proteine
FEN1 (Flap Structure-Specific Endonuclease 1): FEN1 Antikörper FEN1 ELISA Kits FEN1 Proteine
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 Antikörper LIG1 ELISA Kits LIG1 Proteine
RPA1 - Replication Protein A1, 70kDa: RPA1 Antikörper RPA1 ELISA Kits RPA1 Proteine
RPA2 (Replication Protein A2, 32kDa): RPA2 Antikörper RPA2 ELISA Kits RPA2 Proteine
RPA3 (Replication Protein A3, 14kDa): RPA3 Antikörper   RPA3 Proteine

Mismatch Repair

MSH2 - MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli)

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].   More...

MSH3 (MutS Homolog 3 (E. Coli)):

MSH6 (MutS Homolog 6 (E. Coli)):

Antigene in dieser Kategorie:
MLH1 (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)): MLH1 Antikörper MLH1 ELISA Kits MLH1 Proteine
PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)): PMS2 Antikörper PMS2 ELISA Kits PMS2 Proteine
RFC1 - Replication Factor C (Activator 1) 1, 145kDa: RFC1 Antikörper RFC1 ELISA Kits RFC1 Proteine
RFC2 (Replication Factor C (Activator 1) 2, 40kDa): RFC2 Antikörper RFC2 ELISA Kits RFC2 Proteine
RFC3 - Replication Factor C (Activator 1) 3, 38kDa: RFC3 Antikörper RFC3 ELISA Kits RFC3 Proteine
RFC4 (Replication Factor C (Activator 1) 4, 37kDa): RFC4 Antikörper RFC4 ELISA Kits RFC4 Proteine
RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): RFC5 Antikörper RFC5 ELISA Kits RFC5 Proteine
POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: POLD1 Antikörper POLD1 ELISA Kits POLD1 Proteine
POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): POLD2 Antikörper POLD2 ELISA Kits POLD2 Proteine
POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: POLD3 Antikörper POLD3 ELISA Kits POLD3 Proteine
PCNA (Proliferating Cell Nuclear Antigen): PCNA Antikörper PCNA ELISA Kits PCNA Proteine
LIG1 (Ligase I, DNA, ATP-Dependent): LIG1 Antikörper LIG1 ELISA Kits LIG1 Proteine
RPA1 - Replication Protein A1, 70kDa: RPA1 Antikörper RPA1 ELISA Kits RPA1 Proteine
RPA2 (Replication Protein A2, 32kDa): RPA2 Antikörper RPA2 ELISA Kits RPA2 Proteine
RPA3 (Replication Protein A3, 14kDa): RPA3 Antikörper   RPA3 Proteine
EXO1 - Exonuclease 1: EXO1 Antikörper EXO1 ELISA Kits EXO1 Proteine

Direct Reversal

MGMT (O6-Methylguanine-DNA-Methyltransferase):

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a   More...

ALKBH - AlkB, Alkylation Repair Homolog 1 (E. Coli)

ALKBH2 - AlkB, Alkylation Repair Homolog 2

Antigene in dieser Kategorie:
ALKBH3 - AlkB, Alkylation Repair Homolog 3 (E. Coli): ALKBH3 Antikörper ALKBH3 ELISA Kits ALKBH3 Proteine

Trans-Lesion Synthesis

POLI - Polymerase (DNA Directed) iota

POLH - Polymerase (DNA Directed), eta

Antigene in dieser Kategorie:
REV3L (REV3-Like, Polymerase (DNA Directed), Zeta, Catalytic Subunit): REV3L Antikörper    
REV1 (REV1, Polymerase (DNA Directed)): REV1 Antikörper REV1 ELISA Kits REV1 Proteine
POLK - Polymerase (DNA Directed) kappa: POLK Antikörper POLK ELISA Kits POLK Proteine
PCNA (Proliferating Cell Nuclear Antigen): PCNA Antikörper PCNA ELISA Kits PCNA Proteine