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Mouse (Murine) TRPV1 ELISA Kit für Sandwich ELISA - ABIN428807
Rehman, Bhat, Panda, Mabalirajan: TRPV1 inhibition attenuates IL-13 mediated asthma features in mice by reducing airway epithelial injury. in International immunopharmacology 2013
Results demonstrate that cell motility and Ca(2 (zeige CA2 ELISA Kits)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
Mean TRPV-1 and TRPA-1 (zeige TRPA1 ELISA Kits) gene expression was higher in IPF patients compared with controls, but the difference did not reach statistical significance. Immunostaining supported these findings
TRPV1 and TRPA1 (zeige TRPA1 ELISA Kits) also act as nociceptive sensors and potentiate the inflammatory process.
studies identified TRPV4 (zeige TRPV4 ELISA Kits) as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 (zeige TRPV4 ELISA Kits) in itch signaling involves TRPV1-mediated facilitation.
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
The TRPV1 transcript was present in prostate cancer-affected foci, both in the tumor tissue as well as in the adjacent untransformed part of the gland. All breast carcinoma cell lines showed robust expression of TRPV1. Trigeminal ganglion expressed significantly higher levels of TRPV1 protein than either breast or prostate cancer cells. Ectopic expression of TRPV1 decreases cancer cell survival by induction of apoptosis.
This activity is independent of the NGF (zeige NGFB ELISA Kits) pathway and is not mediated by known TRPV1 toxins' binding sites.
It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX (zeige SLC24A6 ELISA Kits) and MCU (zeige MCU ELISA Kits).
Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca(2 (zeige CA2 ELISA Kits)+) oscillations.
The distinct localization of TRPV1 receptor, supports the concept of a role in the functional activity of the trigeminal sensory system.
The slow sustained current mediated by TRPV1.
Study suggests that deletion of TRPV1 receptors prevents reduction of hyperthermic seizure susceptibility in older mouse pups via a mechanism independent of hyperthermia-induced respiratory alkalosis, but possibly involves impaired development of thermoregulatory mechanisms, although at present, the mechanisms remain unknown.
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Depending on the concentration, lidocaine employs TRPV1, TRPA1 (zeige TRPA1 ELISA Kits) and intracellular Ca2 (zeige CA2 ELISA Kits)+ stores to induce a Ca2 (zeige CA2 ELISA Kits)+-dependent release of the neuropeptide CGRP (zeige CALCA ELISA Kits). Lidocaine-evoked cell death does not seem to require Ca2 (zeige CA2 ELISA Kits)+ influx through TRPV1 or TRPV1
However, the mechanism that induces release of IL-6 (zeige IL6 ELISA Kits) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (zeige IL6 ELISA Kits) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (zeige PKC ELISA Kits), and cAMP response element-binding protein (zeige CREB ELISA Kits) signal transduction pathway.
Blockade of TRPV1, through genetic deletion or systemic or intra-nucleus accumbens (NAc (zeige NLRP1 ELISA Kits)) pharmacological means, inhibited morphine-induced CPP in mice. In addition, p38 MAPK (zeige MAPK14 ELISA Kits) inhibition blocked development of morphine conditioned place preference (CPP) as well. Moreover, blockade of either NAc (zeige NLRP1 ELISA Kits) p38 MAPK (zeige MAPK14 ELISA Kits) or TRPV1 dampened protein expression levels of p-p38 MAPK (zeige MAPK14 ELISA Kits), AC1, and p-NF-kappaB (zeige NFKB1 ELISA Kits) which are normally induced by morphine ...
Results suggest the involvement of TRPV1 in allergic asthma.
Sensitization was relieved by pharmacological block of TRPV1 afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 (zeige CACNA1H ELISA Kits) channel activity. This neuronal-activity-induced USP5 (zeige USP5 ELISA Kits) upregulation may underlie a protective, transient sensitization of the pain pathway.
antiobesity effect of KetoA was caused by TRPV1 activation-mediated browning in WAT. KetoA produced in the gut (zeige GUSB ELISA Kits) could therefore be involved in the regulation of host energy metabolism.
These findings indicate the EPO (zeige EPO ELISA Kits)-induced Ca(2 (zeige CA2 ELISA Kits)+) influx via the activation of the PLC-gamma1 (zeige PLCG1 ELISA Kits) signalling pathway, which leads to TRPV1 activation and consequently increases...angiogenesis.
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (zeige CA2 ELISA Kits)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (zeige TBXA2R ELISA Kits) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (zeige CALCA ELISA Kits) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (zeige AQP5 ELISA Kits) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein