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This study found that the CSF (zeige CSF2 Proteine) levels of synaptotagmin-1 (zeige SYT1 Proteine) were consistently elevated in patients with dementia due to Alzheimer's disease.
Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 (zeige SSX2 Proteine) tumors. Re-analysis of human SS18-SSX1 (zeige SSX1 Proteine) and SS18-SSX2 (zeige SSX2 Proteine) tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 (zeige SSX2 Proteine) expression in SS18-SSX1 (zeige SSX1 Proteine) tumors.
SYT-SSX (zeige SSX2 Proteine) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (zeige CA2 Proteine)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (zeige CA2 Proteine)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (zeige SYT1 Proteine) and Syt-7 (zeige SYT7 Proteine) isoforms.
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 (zeige BICD1 Proteine) and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.
Data show that SS18/SSX (zeige SSX2 Proteine) tightly regulates the elevated expression of the key Wnt (zeige WNT2 Proteine) target AXIN2 (zeige AXIN2 Proteine) in primary synovial sarcoma.
These findings identify Syt1 (zeige SYT1 Proteine) as a novel Ca(2 (zeige CA2 Proteine)+)-sensitive PS1 (zeige PSEN1 Proteine) modulator that could regulate synaptic ABETA (zeige APP Proteine), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT-SSX (zeige SSX2 Proteine) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (zeige CA2 Proteine)+).
disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion
Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, protein SSXT
, synovial sarcoma translocated to X chromosome protein
, synovial sarcoma, translocated to X chromosome
, synovial sarcoma associated SS18-beta
, synovial sarcoma associated SS18-delta
, synovial sarcoma associated SS18-gamma
, synovial sarcoma-associated Ss18-alpha