Synovial Sarcoma Translocation, Chromosome 18 Proteine (SS18)

Bezeichnung:
Synovial Sarcoma Translocation, Chromosome 18 Proteine (SS18)
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Synonyme:
D130059H17, P65, Ssxt, SVP65, Syt
alle Proteine anzeigen Gen GeneID UniProt
SS18 6857 P21579
SS18 268996 Q62280
Ratte SS18 SS18 361295  

Weitere Synonyme anzeigen

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Weitere Proteine zu Synovial Sarcoma Translocation, Chromosome 18 Interaktionspartnern

Human Synovial Sarcoma Translocation, Chromosome 18 (SS18) Interaktionspartner

  1. SYT-SSX (zeige SSX2 Proteine) fusion is associated with synovial sarcoma.

  2. the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (zeige CA2 Proteine)+)-regulated tethers to the Pplasma membrane.

  3. Data indicate that small protein sequence changes in the Ca(2 (zeige CA2 Proteine)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (zeige SYT1 Proteine) and Syt-7 (zeige SYT7 Proteine) isoforms.

  4. Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 (zeige BICD1 Proteine) and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation.

  5. Data show that SS18/SSX (zeige SSX2 Proteine) tightly regulates the elevated expression of the key Wnt (zeige WNT2 Proteine) target AXIN2 (zeige AXIN2 Proteine) in primary synovial sarcoma.

  6. These findings identify Syt1 (zeige SYT1 Proteine) as a novel Ca(2 (zeige CA2 Proteine)+)-sensitive PS1 (zeige PSEN1 Proteine) modulator that could regulate synaptic ABETA (zeige APP Proteine), opening avenues for novel and selective synapse targeting therapeutic strategies.

  7. One-Step reverse transcriptase real time PCR for the detection SYT-SSX (zeige SSX2 Proteine) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.

  8. membrane tethering by E-Syt1 (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (zeige CA2 Proteine)+).

  9. a rare variant of the SS18-SSX1 (zeige SSX1 Proteine) fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed

  10. A dominant negative de novo SYT1 (zeige SYT1 Proteine) missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.

Mouse (Murine) Synovial Sarcoma Translocation, Chromosome 18 (SS18) Interaktionspartner

  1. disruption of the Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental vascularization and/or chorio-allantoic fusion

  2. Syt may contribute to the signaling pathway important for various cellular functions in vivo and in vitro, and we propose that Syt-deficient MEFs would be a powerful means to understand the biological roles of SYT in vitro.

Synovial Sarcoma Translocation, Chromosome 18 (SS18) Protein Überblick

Protein Überblick

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001

Alternative names and synonyms associated with Synovial Sarcoma Translocation, Chromosome 18 (SS18)

  • synaptotagmin I (SYT1)
  • synovial sarcoma translocation, chromosome 18 (SS18)
  • synovial sarcoma translocation, Chromosome 18 (Ss18)
  • D130059H17 Protein
  • P65 Protein
  • Ssxt Protein
  • SVP65 Protein
  • Syt Protein

Bezeichner auf Proteinebene für SS18

synaptotagmin 1 , synaptotagmin-1 , sytI , protein SSXT , synovial sarcoma translocated to X chromosome protein , synovial sarcoma, translocated to X chromosome , synovial sarcoma associated SS18-beta , synovial sarcoma associated SS18-delta , synovial sarcoma associated SS18-gamma , synovial sarcoma-associated Ss18-alpha

GENE ID SPEZIES
6857 Homo sapiens
6760 Homo sapiens
268996 Mus musculus
361295 Rattus norvegicus
100173694 Pongo abelii
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