SLC38A2 Proteine (SLC38A2)

Bezeichnung:
Solute Carrier Family 38, Member 2 Proteine (SLC38A2)
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Synonyme:
5033402L14Rik, AI316867, Ata2, Atrc2, mKIAA1382, PRO1068, Sat2, slc38a2, Snat2
alle Proteine anzeigen Gen GeneID UniProt
SLC38A2 54407 Q96QD8
SLC38A2 67760 Q8CFE6
Ratte SLC38A2 SLC38A2 29642 Q9JHE5

Weitere Synonyme anzeigen

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Weitere Proteine zu SLC38A2 Interaktionspartnern

Human Solute Carrier Family 38, Member 2 (SLC38A2) Interaktionspartner

  1. there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function

  2. In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport.

  3. Propose regulation of placental SNAT2/LAT1 (zeige LAT Proteine) ubiquitination by mTORC1 and Nedd4-2 (zeige NEDD4L Proteine).

  4. Decreased placental mTOR (zeige FRAP1 Proteine) activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR.

  5. GADD34 (zeige PPP1R15A Proteine) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter (zeige SLC43A2 Proteine) SNAT2.

  6. Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression.

  7. SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis.

  8. SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows.

  9. Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants.

  10. findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA

Mouse (Murine) Solute Carrier Family 38, Member 2 (SLC38A2) Interaktionspartner

  1. GADD34 (zeige PPP1R15A Proteine) promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter ATA2.

  2. These data reveal an unexpected role for amino acid uptake and the amino acid transporter SNAT2 in regulation of pluripotent cells in culture.

  3. The inward current of Na(+) associated with the function of SNAT2 leads to membrane depolarization and activation of voltage-sensitive Ca(2 (zeige CA2 Proteine)+) channels that mediate Ca(2 (zeige CA2 Proteine)+) influx, thereby leading to an increase in the [Ca(2 (zeige CA2 Proteine)+)](i) in enteroendocrine cells.

  4. Insulin (zeige INS Proteine) promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. (ATA2 or SAT2 (zeige SAT2 Proteine))

  5. crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4 (zeige SLC38A4 Proteine), Slc38a2, and Slc2a3 (zeige SLC2A3 Proteine)) may be a component of the genetic control of nutrient supply and demand during mammalian development

  6. ATA2 on the plasma membrane is subject to polyubiquitination by Nedd4-2 (zeige NEDD4L Proteine) with consequent endocytotic sequestration and proteasomal degradation

  7. the insulin (zeige INS Proteine)-stimulated translocation pathways for ATA2 and GLUT4 (zeige SLC2A4 Proteine) in adipocytes are distinct, involving different storage sites

  8. SNAT2 not only regulates mTOR (zeige FRAP1 Proteine) but also regulates proteolysis through PI3K and provides a link among acidosis, insulin (zeige INS Proteine) resistance, and protein wasting in skeletal muscle cells.

  9. Despite increased ATF4 (zeige ATF4 Proteine) binding at the C/EBP (zeige CEBPA Proteine)-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed

SLC38A2 Protein Überblick

Protein Überblick

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1 (By similarity).

Alternative names and synonyms associated with SLC38A2

  • solute carrier family 38, member 2 (SLC38A2)
  • solute carrier family 38, member 2 (slc38a2)
  • solute carrier family 38, member 2 (LOC100344654)
  • solute carrier family 38, member 2 (Slc38a2)
  • 5033402L14Rik Protein
  • AI316867 Protein
  • Ata2 Protein
  • Atrc2 Protein
  • mKIAA1382 Protein
  • PRO1068 Protein
  • Sat2 Protein
  • slc38a2 Protein
  • Snat2 Protein

Bezeichner auf Proteinebene für SLC38A2

solute carrier family 38, member 2 , Amino acid transporter A2 , sodium-coupled neutral amino acid transporter 2 , sodium-coupled neutral amino acid transporter 2-like , amino acid transporter A2 , system A amino acid transporter 2 , system A transporter 1 , system N amino acid transporter 2 , amino acid transporter 2 , protein 40-9-1 , solute carrier family 38 member 2 , amino acid system A transporter , amino acid transporter cationic 2 , amino acid transporter system A2 , amino acid transporter, cationic 2 (low affinity) , Sodium-coupled neutral amino acid transporter 2 , Solute carrier family 38 member 2 , System A amino acid transporter 2 , System A transporter 1 , System N amino acid transporter 2

GENE ID SPEZIES
451851 Pan troglodytes
496466 Xenopus (Silurana) tropicalis
702253 Macaca mulatta
100344654 Oryctolagus cuniculus
100398972 Callithrix jacchus
100452009 Pongo abelii
100466668 Ailuropoda melanoleuca
100596773 Nomascus leucogenys
417807 Gallus gallus
54407 Homo sapiens
486596 Canis lupus familiaris
338044 Bos taurus
67760 Mus musculus
29642 Rattus norvegicus
446910 Xenopus laevis
100975486 Pan paniscus
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