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SLC22A6 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
this is the first demonstration that Nedd4-1 (zeige NEDD4 ELISA Kits) regulates hOAT1 ubiquitination, expression, and transport activity through its WW2 and WW3 domains
both Nedd4-1 (zeige NEDD4 ELISA Kits) and Nedd4-2 are important regulators for hOAT1 ubiquitination, expression, and function
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (zeige KCNK3 ELISA Kits)/OAT3 (zeige SLC22A8 ELISA Kits).
OAT1 and NaDC3 in the basolateral membrane and OAT4 in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate.
BCL6 (zeige BCL6 ELISA Kits) constitutes a promising candidate gene for the regulation of human OAT1 (zeige KCNK3 ELISA Kits) transcription
Clopidogrel/clopidogrel carboxylate are weak inhibitors of OAT1 (zeige KCNK3 ELISA Kits).
The results confirmed that OAT1 (zeige KCNK3 ELISA Kits), OAT3 (zeige SLC22A8 ELISA Kits), OCT2, MATE1 (zeige SLC47A1 ELISA Kits), and MATE2-K (zeige SLC47A2 ELISA Kits) were coexpressed in tubular epithelial cells.
transport of xanthurenic acid by OAT1 (zeige KCNK3 ELISA Kits) and OAT3 (zeige SLC22A8 ELISA Kits)
PKC isoform PKCalpha (zeige PKCa ELISA Kits) was responsible for OAT1 (zeige KCNK3 ELISA Kits) ubiquitination.
An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3 (zeige SLC22A8 ELISA Kits)).
OAT1-deficient mice showed abnormal LTP (zeige SCP2 ELISA Kits) and higher spine numbers but with a much lesser maturity extent.
At the protein level, mOat3 (zeige SLC22A8 ELISA Kits) and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 (zeige SLC22A8 ELISA Kits) is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.
Oat1 potentially plays a major role in the rate limiting step in the uptake and excretion of putative toxic metabolites
acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1.
functional differences in the relative importance of OAT1 and OAT3 (zeige SLC22A8 ELISA Kits) in antiviral handling in developing and mature tissue
the ontogenic pattern of expression of OAT1 and OAT3 (zeige SLC22A8 ELISA Kits) in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus
Although all cysteine mutants of mOAT1 were sensitive to the inhibition by PCMBS, C49A (zeige IL24 ELISA Kits) was less sensitive than the wild-type mOAT1, suggesting that the modification of Cys49 may play a role in the inhibition of mOAT1 by PCMBS.
analysis of physiological substrates of OAT1
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene.
solute carrier family 22 (organic anion transporter), member 6
, solute carrier family 22 member 6
, Solute carrier family 22 member 6
, organic anion transporter 1
, renal organic anion transporter 1
, putative organic anion transporter
, PAH transporter
, para-aminohippurate transporter
, kidney-specific transport protein
, novel kidney transcript
, organic cationic transporter-like 1
, solute carrier family 22, member 6
, organic cation transporter 1-B
, renal organic anion transporter 1-B
, solute carrier family 22 member 6-B