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TIP1;1 and TIP1;2 single or double mutants did not show significant changes in water content or water retention, and showed no sign of early senescence or growth retardation. [TIP1;2]
Morpholino knockdown of synectin in zebrafish impaired formation of the thoracic duct, due to selective defects in (zeige PROX1 ELISA Kits)lymphangiogenic but not angiogenic sprouting.
Silencing of gipc1 in tadpoles caused lymphatic defects due to an underdevelopment and impaired migration of Prox-1 (zeige PROX1 ELISA Kits)(+) lymphatic endothelial cells.
Results indicate that kermit 2/XGIPC is a novel component of the IGF pathway, potentially functioning through modulation of the IGF1 (zeige IGF1 ELISA Kits) receptor.
Upregulated expression of GIPC1 is associated with glioma.
Drd3 (zeige DRD3 ELISA Kits) palmitoylation acts as a molecular switch for Drd3 (zeige DRD3 ELISA Kits)-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs.
The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells.
GIPC binds LPA(1 (zeige LPAR1 ELISA Kits)) and promotes its trafficking from APPL (zeige APPL1 ELISA Kits)-containing signaling endosomes to EEA1 (zeige EEA1 ELISA Kits) early endosomes and thus attenuates LPA (zeige APOA ELISA Kits)-mediated Akt (zeige AKT1 ELISA Kits) signaling from APPL (zeige APPL1 ELISA Kits) endosomes.
Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer.
a novel non-Smad (zeige SMAD1 ELISA Kits) function for endoglin (zeige ENG ELISA Kits) and GIPC in regulating endothelial cell function during angiogenesis
The placental lectins reduced the binding of IGF-I (zeige IGF1 ELISA Kits) to IGF-1 (zeige IGF1 ELISA Kits) receptor in a dose-dependent manner.
Knockdown of ADRM1 (zeige Adrm1 ELISA Kits) in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK (zeige RECK ELISA Kits) RNA and protein
GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells
Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Higher ratios of PSD-95 (zeige DLG4 ELISA Kits)/GluN2B (zeige GRIN2B ELISA Kits) and GAIP-interacting protein C (zeige PROC ELISA Kits)-terminus (GIPC)/GluN2B (zeige GRIN2B ELISA Kits) were associated with poorer learning index scores across all ages.
findings identify Gipc1 as a new interactor for Vangl2 (zeige VANGL2 ELISA Kits); show that a myosin VI (zeige MYO6 ELISA Kits)-Gipc1 protein complex can regulate Vangl2 (zeige VANGL2 ELISA Kits) traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3 (zeige TGFBR3 ELISA Kits)(-/-) mice
GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Synectin is widely distributed in adult cells and tissues, and in the embryo apparent at day 4.5, peaks at day 12.5 and declines by day 18.5, and may be involved in mediation of outside-in signaling.
Synectin selectively regulates arterial branching morphogenesis.
Results define an important role for the Myo6 (zeige MYO6 ELISA Kits)-GIPC1 motor complex in presynaptic function and in BDNF (zeige BDNF ELISA Kits)-TrkB (zeige NTRK2 ELISA Kits)-mediated synaptic plasticity.
a prototypical GIPC/synectin-binding receptor, revealed that deletion of its PDZ (zeige INADL ELISA Kits)-binding motif drastically reduced GIPC/synectin and myosin VI (zeige MYO6 ELISA Kits) recruitment to endocytic vesicles
results confirm synectin involvement in FGF2 (zeige FGF2 ELISA Kits)-dependent signal transduction and provide insights into synectin-dependent gene expression in the endothelium
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008
GIPC PDZ domain containing family, member 1
, GIPC PDZ domain containing family, member 3
, regulator of G-protein signalling 19 interacting protein 1
, RGS-GAIP interacting protein GIPC
, rgs-gaip interacting protein gipc
, PDZ domain-containing protein GIPC1
, PDZ domain-containing protein
, regulator of G-protein signaling 19-interacting protein 1
, developmental regulator
, GAIP C-terminus-interacting protein
, GLUT1 C-terminal binding protein
, IGF-1 receptor interacting protein 1
, RGS-GAIP-interacting protein
, RGS19-interacting protein 1
, tax interaction protein 2
, Tax interacting protein, clone 2
, regulator of G-protein signaling 19 interacting protein 1
, semaF cytoplasmic domain associated protein
, semaF cytoplasmic domain-associated protein 1
, GLUT1 C-terminal-binding protein
, RGS-GAIP interacting protein C-terminus
, RGS-GAIP interacting protein, C-terminus