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CNBP (zeige CNBP Proteine) up-regulates tbx2b and smarca5, and down-regulates wnt5b (zeige WNT5B Proteine) gene expression.
The tight coupling of ATP hydrolysis to DNA translocation suggests that DNA translocation is not energetically rate limiting for nucleosome repositioning by ISWI.
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
Plays a critical role for ISWI chromatin remodeling complexes in neural development, including eye differentiation, in the Xenopus laevis embryo.
present the X-ray structure of Xenopus laevis ISWI SANT domain, derived from limited proteolysis of a C-terminal fragment of ISWI protein
A model has been proposed in which a base excision repair complex containing damaged chromatin is recruited to specific locations in the nuclear matrix for repair, with this recruitment mediated by XRCC1 (zeige XRCC1 Proteine)-SNF2H interaction.
Overexpression of hSNF2H is associated with glioma.
The action of SNF2H at CTCF (zeige CTCF Proteine) sites is functionally important as depletion of CTCF (zeige CTCF Proteine) or SNF2H affects transcription of a common group of genes.
Knockdown of SMARCA5 expression in MDA-MB-231 and MDA-MB-435s cell lines.
Data show the mechanism of nucleosome sliding by the chromatin remodeling motor SNF2h protein.
CHD3.1 and ACF1 (zeige BAZ1A Proteine)-SNF2H display counteractive activities but similar histone affinities.
Data show that CCCTC-binding factor (CTCF (zeige CTCF Proteine)) together with ISWI (zeige SMARCA1 Proteine) ATPase SMARCA5 and members of the Cohesin complex (zeige SMC3 Proteine) associate with the SPI1 (zeige SPI1 Proteine) protein is disrupted in acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) blasts.
SMARCA5 targeting to UV-C damage depends on transcription and histone modifications and requires functional SWI2/SNF2 (zeige SMARCA2 Proteine)-ATPase and SLIDE domains.
this study finds that the H4 tail promotes ATP-binding pocket closure in SNF2h.
study unveils a functional link between DNA damage-induced poly(ADP-ribosyl)ation, SMARCA5-mediated chromatin remodeling and RNF168 (zeige RNF168 Proteine)-dependent signaling and repair of DSBs.
Snf2h is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation.
Snf2h controls chromatin organization and histone H1 (zeige H1F0 Proteine) dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation.
The results demonstrated a novel role of CECR2 (zeige CECR2 Proteine)-containing complexes in spermatogenesis and showed that CECR2 (zeige CECR2 Proteine) interacts predominantly with SNF2H instead of SNF2L (zeige SMARCA1 Proteine) in the testis.
role for SNF2H in both repression and activation of cytokine genes.
Smarca5 is a key regulator of global chromatin structure.
Smarca5-NoRC complex has a role in heterochromatin formation and silencing of ribosomal gene transcription
Snf2h-/- embryos die during the periimplantation stage. Blastocyst outgrowth experiments indicate that loss of Snf2h results in growth arrest and cell death of both the trophectoderm and inner cell mass.
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
, actin dependent regulator of chromatin A5
, matrix associated
, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
, imitation switch ISWI
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a5
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
, sucrose nonfermenting protein 2 homolog
, sucrose nonfermenting-like 5