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This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 (zeige BMP2 ELISA Kits) account for about 7% of infants with midline forms of craniosynostosis.
Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7 (zeige BMP7 ELISA Kits)-induced adipogenesis
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Loss of SMAD6 is associated with lung adenocarcinoma.
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
results suggest that MyD88 (zeige MYD88 ELISA Kits) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (zeige TGFB1 ELISA Kits)-mediated negative regulation of MyD88 (zeige MYD88 ELISA Kits)-dependent pro-inflammatory signalling
Data show that Runx1 (zeige RUNX1 ELISA Kits), in conjunction with Fli1 (zeige FLI1 ELISA Kits), Gata2 (zeige GATA2 ELISA Kits), and Scl (zeige KRT7 ELISA Kits), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
Smad6 and Smad7, inhibitors of BMP signaling, were up-regulated in HFE-mutant hereditary hemochromatosis compared to controls, disruptin bone morphogenic protein signaling.
A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (zeige NKX2-5 ELISA Kits)).
These results indicate that PRIP (zeige NCOA6 ELISA Kits) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (zeige SMAD1 ELISA Kits) phosphorylation, through the methylation of inhibitory Smad6
These findings suggest that TNF-alpha (zeige TNF ELISA Kits) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (zeige BMP2 ELISA Kits) signaling inhibitor, Smad6.
The Smad6 is a novel target of Arkadia (zeige RNF111 ELISA Kits), and that Arkadia (zeige RNF111 ELISA Kits) positively regulates BMP signalling via degradation of Smad6, Smad7 (zeige SMAD7 ELISA Kits) and c-Ski (zeige SKI ELISA Kits)/SnoN (zeige SKIL ELISA Kits).
Smad6 inhibits non-canonical TGF-beta1 (zeige TGFB1 ELISA Kits) signaling by recruiting the deubiquitinase A20 (zeige TNFAIP3 ELISA Kits) to TRAF6 (zeige TRAF6 ELISA Kits).
Hepcidin (zeige HAMP ELISA Kits), Smad6 and Smad7 (zeige SMAD7 ELISA Kits) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (zeige SMAD1 ELISA Kits) signaling pathway.
Sema7A (zeige SEMA7A ELISA Kits) positively regulates the production of transforming growth factor (TGF)-beta1 (zeige TGFB1 ELISA Kits) and Smad6 to facilitate West Nile virus pathogenesis in mice.
Results indicate that peptidyl-prolyl isomerase (zeige PPI ELISA Kits) Pin1 (zeige PIN1 ELISA Kits) Associates with Smad3 (zeige SMAD3 ELISA Kits) and Smad6.
Data show that Runx1 (zeige RUNX1 ELISA Kits), in conjunction with Fli1 (zeige FLI1 ELISA Kits), Gata2 (zeige GATA2 ELISA Kits), and Scl (zeige TAL1 ELISA Kits), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD, mothers against DPP homolog 6
, MAD homolog 6
, Mothers against decapentaplegic, drosophila, homolog of, 6
, SMAD 6
, mothers against DPP homolog 6
, mothers against decapentaplegic homolog 6
, Smad 6
, mad homolog 7
, MAD, mothers against decapentaplegic homolog 6