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The bromodomain and extraterminal domain (BET) family consists of BRDT (zeige BRDT ELISA Kits), BRD2 (zeige BRD2 ELISA Kits), BRD3 (zeige BRD3 ELISA Kits), and BRD4 (zeige BRD4 ELISA Kits), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The identification of RNF43 (zeige RNF43 ELISA Kits) mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease
LRP1B (zeige LRP1B ELISA Kits), BRD2 (zeige BRD2 ELISA Kits) and CACNA1D (zeige CACNA1D ELISA Kits) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (zeige CHUK ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 (zeige BRD2 ELISA Kits) and BRD4 (zeige BRD4 ELISA Kits) in maintaining oncogenic IKK (zeige CHUK ELISA Kits) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 (zeige BRD2 ELISA Kits) and Brd4 (zeige BRD4 ELISA Kits), may play a key role in the regulation of Nrf2 (zeige GABPA ELISA Kits)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 (zeige BRD2 ELISA Kits) is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2 (zeige BRD2 ELISA Kits)/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
The SNP alleles in BRD2 (zeige BRD2 ELISA Kits), Cx-36 (zeige GJD2 ELISA Kits), and ME2 (zeige CELSR1 ELISA Kits) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'
BRD2 (zeige BRD2 ELISA Kits), BRD3 (zeige BRD3 ELISA Kits), and BRD4 (zeige BRD4 ELISA Kits) interact with gammaretroviral INs (zeige INS ELISA Kits) and serve as cofactors for murine leukemia virus integration.
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined.
polycomb group ring finger 3
, polycomb group RING finger protein 3
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, RING finger protein 3A
, ring finger protein 3