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Human Polyclonal PCGF2 Primary Antibody für ELISA, WB - ABIN249894
Ishida, Asano, Hasegawa, Koseki, Ono, Yoshida, Taniguchi, Kanno: Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. in Gene 1993
Suggest a novel role of PCGF2 in arsenic trioxide-mediated degradation of PML (zeige PML Antikörper)-RARA (zeige RARA Antikörper) that PCGF2 might act as a negative regulator of UBE2I (zeige UBE2I Antikörper) via direct interaction.
Mel-18 underexpression in luminal breast cancer cells caused ER-alpha (zeige ESR1 Antikörper) downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 (zeige ESR1 Antikörper) transactivators p53 (zeige TP53 Antikörper) and SP1 (zeige PSG1 Antikörper).
It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression.
Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer.
Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt (zeige WNT2 Antikörper)-mediated Notch (zeige NOTCH1 Antikörper) signaling.
PCGF2, a PRC1 (zeige PRC1 Antikörper) gene, played a negative role in the granulocytic differentiation of human APL (zeige FASL Antikörper) cells.
these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha (zeige HIF1A Antikörper) and its target VEGF (zeige VEGFA Antikörper) expressions mediated by the PTEN (zeige PTEN Antikörper)/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
Loss of Mel-18 is associated with prostate cancer.
Our analysis showed correlation between BMI1 (zeige BMI1 Antikörper) and PCGF2 gene's expression and survival in children with medulloblastoma.
Bmi-1 (zeige BMI1 Antikörper)/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy.
BMI1 (zeige BMI1 Antikörper) and MEL18 contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b (zeige REG3B Antikörper). REG3B (zeige REG3B Antikörper) negatively regulates cytokine-induced activation of STAT3 (zeige STAT3 Antikörper) in colon epithelial cells.
Data indicate that Bmi1 (zeige BMI1 Antikörper) and Mel18 have opposing functions and are present in distinct complexes.
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Data show that Mel-18 and Ezh2 (zeige EZH2 Antikörper) positively regulate the expression of Il17a (zeige IL17A Antikörper) and Il17f (zeige IL17F Antikörper).
Chemokine (zeige CCL1 Antikörper)-mediated thymopoiesis is regulated by a mammalian Polycomb (zeige CBX2 Antikörper) group gene, mel-18
the stoichiometry and/or equilibrium of subunits of the class II Polycomb complex containing Mel-18 might be regulated by changes in phosphorylation status via the PKC signaling pathway
Results provide genetic evidence that Cited2 (zeige CITED2 Antikörper) controls the expression of INK4a/ARF (zeige CDKN2A Antikörper) and fibroblast proliferation, at least in part via the polycomb (zeige CBX2 Antikörper)-group genes Bmi1 (zeige BMI1 Antikörper) and Mel18.
Loss or knockdown of mel-18 leads to the expression of Hoxb4 (zeige HOXB4 Antikörper), an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC (zeige FUT1 Antikörper) self-renewal.
Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
Sf3b1 (zeige SF3B1 Antikörper)-Zfp144 protein interaction is essential for true Polycomb (zeige CBX2 Antikörper) group proteins mediated repression of Hox (zeige MSH2 Antikörper) genes.
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
polycomb group RING finger protein 2
, zinc finger protein 144 (Mel-18) (human homolog)
, polycomb group ring finger 2
, ring finger protein 110
, DNA-binding protein Mel-18
, zinc finger protein 144
, melanoma nuclear protein 18