anti-MBD2 (MBD2) Antikörper

Bezeichnung:
anti-Methyl-CpG Binding Domain Protein 2 Antikörper (MBD2)
Auf www.antikoerper-online.de finden Sie aktuell 125 Methyl-CpG Binding Domain Protein 2 (MBD2) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MBD2 Proteine (3) und MBD2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 135 MBD2 Produkte verfügbar.
Synonyme:
DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862

Meistgesuchte Reaktivitäten zu anti-MBD2 (MBD2) Antikörper

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anti-Human MBD2 Antikörper:

anti-Mouse (Murine) MBD2 Antikörper:

anti-Rat (Rattus) MBD2 Antikörper:

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Am meisten referenzierte anti-MBD2 Antikörper

  1. Human Polyclonal MBD2 Primary Antibody für EIA, WB - ABIN356599 : Zhu, Spitz, Zhang, Grossman, Frazier, Wu: Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. in Cancer 2004 (PubMed)
    Zeige alle 5 Referenzen für 356599

  2. Human Polyclonal MBD2 Primary Antibody für IF, WB - ABIN1881531 : Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010 (PubMed)
    Zeige alle 3 Referenzen für 1881531

  3. Human Polyclonal MBD2 Primary Antibody für IHC (p), IHC - ABIN188691 : Tan, Nakielny: Control of the DNA methylation system component MBD2 by protein arginine methylation. in Molecular and cellular biology 2006 (PubMed)
    Zeige alle 2 Referenzen für 188691

  4. Human Polyclonal MBD2 Primary Antibody für IHC, WB - ABIN2779675 : Xing, Stewart, Gu, Lu, Spitz, Wu: Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. in British journal of cancer 2008 (PubMed)
    Zeige alle 2 Referenzen für 2779675

  5. Human Polyclonal MBD2 Primary Antibody für WB - ABIN387915 : Ghoshal, Majumder, Datta, Motiwala, Bai, Sharma, Frankel, Jacob: Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 2 Referenzen für 387915

  6. Human Polyclonal MBD2 Primary Antibody für IHC, ELISA - ABIN334432 : Auriol, Billard, Magdinier, Dante: Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. in Nucleic acids research 2005 (PubMed)
    Zeige alle 2 Referenzen für 334432

  7. Cow (Bovine) Polyclonal MBD2 Primary Antibody für IHC, WB - ABIN2778640 : Le Guezennec, Vermeulen, Brinkman, Hoeijmakers, Cohen, Lasonder, Stunnenberg: MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. in Molecular and cellular biology 2006 (PubMed)

  8. Human Polyclonal MBD2 Primary Antibody für ICC, IF - ABIN257102 : Kim, Kwak, Weitz: Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. in Molecular cell 2014 (PubMed)

Weitere Antikörper gegen MBD2 Interaktionspartner

Human Methyl-CpG Binding Domain Protein 2 (MBD2) Interaktionspartner

  1. CpG and methylation-dependent DNA binding and dynamics of the MBD2 (zeige DPEP2 Antikörper) protein at the single-molecule level have been reported.

  2. Results show that MBD2 (zeige DPEP2 Antikörper) mediates epigenetic silencing of Htra1 (zeige HTRA1 Antikörper).

  3. MBD2 (zeige DPEP2 Antikörper) has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.

  4. MBD2 (zeige DPEP2 Antikörper) expression was elevated in HCC (zeige FAM126A Antikörper) tissue, which suggesting MBD2 (zeige DPEP2 Antikörper) as a candidate prognostic marker of HCC (zeige FAM126A Antikörper).

  5. downregulation of miR (zeige MLXIP Antikörper)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (zeige DPEP2 Antikörper) in the human OSCC cell line UM1.

  6. Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (zeige DPEP1 Antikörper) domain and MBD2 (zeige DPEP2 Antikörper) C-terminus.

  7. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  8. The dynamics of MBD2 (zeige DPEP2 Antikörper) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.

  9. Data suggest that MBD2 (zeige DPEP2 Antikörper) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (zeige DPEP2 Antikörper) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.

  10. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (zeige DPEP2 Antikörper) for methylated DNA.

Mouse (Murine) Methyl-CpG Binding Domain Protein 2 (MBD2) Interaktionspartner

  1. MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.

  2. Loss of Mbd2 resulted in impaired implementation of above DNA methylation (zeige HELLS Antikörper) changes associated with altered energy homeostasis, which then protected mice from HFD-induced obesity and insulin (zeige INS Antikörper) resistance.

  3. Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.

  4. MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.

  5. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (zeige HLX Antikörper).

  6. Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.

  7. miR (zeige MLXIP Antikörper)-290/371-Mbd2-Myc (zeige MYC Antikörper) circuit regulates glycolytic metabolism to promote pluripotency.

  8. these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (zeige SCN3A Antikörper) expression during postnatal development and seizure condition.

  9. Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (zeige AMD1 Antikörper)).

  10. In metastatic colorectal cancer cells, reduced levels of miR (zeige MLXIP Antikörper)-221* and miR (zeige MLXIP Antikörper)-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin (zeige SERPINB5 Antikörper).

MBD2 Antigen-Profil

Beschreibung des Gens

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MBD2

  • methyl-CpG binding domain protein 2 (MBD2) Antikörper
  • methyl-CpG binding domain protein 2 (LOC100345590) Antikörper
  • methyl-CpG binding domain protein 2 (Mbd2) Antikörper
  • methyl-CpG binding domain protein 2 (mbd2) Antikörper
  • DMTase Antikörper
  • MBD2 Antikörper
  • MBD2a Antikörper
  • NY-CO-41 Antikörper
  • wu:fa97f06 Antikörper
  • zgc:111862 Antikörper

Bezeichner auf Proteinebene für MBD2

methyl-CpG binding domain protein 2 , demethylase , methyl-CpG-binding domain protein 2 , methyl-CpG-binding protein MBD2 , methyl-CpG binding protein MBD2

GENE ID SPEZIES
455427 Pan troglodytes
100345590 Oryctolagus cuniculus
693801 Macaca mulatta
8932 Homo sapiens
17191 Mus musculus
337105 Danio rerio
399118 Xenopus laevis
497269 Gallus gallus
483975 Canis lupus familiaris
100337206 Bos taurus
680172 Rattus norvegicus
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