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HMGN1 and HMGN 2 (zeige HMGN2 Proteine) remodel core and linker histone tail domains within chromatin.
RNA-seq evidence of biallelic expression of HMGN1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of HMGN1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (zeige WRB Proteine) differentially methylated region (DMR (zeige WDR20 Proteine)) in disomic controls or trisomy (Down syndrome) individuals.
HMGN1 can serve as a useful clinical parameter for evaluating disease progression and predicting the outcomes for early-stage patients with non-small cell lung cancer .
nucleosome binding protein HMGN1 as a new PCNA (zeige PCNA Proteine)-interacting protein that enhances the binding of PCNA (zeige PCNA Proteine) to chromatin
extracellular HMGN1 acts as a novel alarmin critical for LPS (zeige IRF6 Proteine)-induced development of innate and adaptive immune responses.
HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice
HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I (zeige DNASE1 Proteine) hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites.
Results show that four serine residues, i.e., Ser6, Ser85, Ser88, and Ser98, can be phosphorylated in high mobility group (zeige SSRP1 Proteine) N1 (HMGN1).
HMGN1 optimizes the cellular response to ionizing radiation and to other tumorigenic events; therefore, loss of this protein increases the tumor burden in mice.
SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) functions independently of HMGN1
Suggest Hmgn1/Cebpb (zeige CEBPB Proteine) signaling may play an important role during mouse decidualization.
our findings show that HMGN1 contributes to antitumor immunity and it may offer an effective adjuvant to heighten responses to cancer vaccines.
in mice, loss of HMGN1 leads to transcription changes that accelerate the progression of DEN-induced hepatocarcinogenesis, without affecting the type of tumors or the final total tumor burden of these mice.
HMGN1 is a nucleosome remodeling protein encoded on chromosome 21q22 that suppresses H3K27me3 and promotes both B cell proliferation in vitro and B-ALL in vivo
HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I (zeige DNASE1 Proteine) hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Phenotypic analysis of Hmgn1(tm1/tm1 (zeige TPM2 Proteine)), Hmgn3 (zeige HMGN3 Proteine)(tm1/tm1 (zeige TPM2 Proteine)), and Hmgn5 (zeige HMGN5 Proteine)(tm1/tm1 (zeige TPM2 Proteine)) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.
a regulatory role for HMGN1 in PARP-1 (zeige PARP1 Proteine) activation.
extracellular HMGN1 acts as a novel alarmin critical for LPS (zeige TLR4 Proteine)-induced development of innate and adaptive immune responses.
Regulation of Hmgn1 and Fgf18 (zeige FGF18 Proteine) at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis.
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
high mobility group nucleosome-binding domain-containing protein 1
, high-mobility group (nonhistone chromosomal) protein 14
, high-mobility group nucleosome binding 1
, high-mobility group nucleosome binding domain 1
, non-histone chromosomal protein HMG-14
, nonhistone chromosomal protein HMG-14
, high-mobility group nucleosome binding domain 1 b
, high mobility group protein 14
, high-mobility group nucleosome-binding domain-containing protein 1
, HMG-14 protein
, non-histone chromosomal protein HMG-14B