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Liposomes modified with both apolipoproteins A-I and E were internalized in HepG2 cells in FBS (zeige FBXO8 ELISA Kits)-depleted culture medium at the same levels as unmodified liposomes in FBS (zeige FBXO8 ELISA Kits)-containing culture medium, which indicates that apolipoproteins A-I and E were the major serum components involved in liposomal binding to SR-B1 or LDLR (zeige LDLR ELISA Kits) (or both).
Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.
the cigarette smoke (CS)-induced loss of SRB1 induced an alteration of sebocytes lipid content, also demonstrated by cholesterol quantification in SRB1 siRNA experiments. In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality
Low SRB1 expression is associated with non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma.
SCARB1 rs5888 and environmental oxidative stress have a prominent role in age-related macular degeneration(ARMD) susceptibility, early ARMD progression to advanced stage disease and even in the outcome of the disease-an area of macular lesion.
SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL (zeige HSD11B1 ELISA Kits) cholesterol and Lp(a (zeige APOA ELISA Kits)). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a (zeige APOA ELISA Kits)).
Data suggest that activation of SR-BI by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (zeige S1PR2 ELISA Kits)-mediated inflammation in vascular endothelial cells by activating the PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathway; oxidized-LDL does the opposite. (APOA1 (zeige APOA1 ELISA Kits) = apolipoprotein A-I (zeige APOA1 ELISA Kits); SR-BI/SCARB1 = scavenger receptor class B type I; S1PR2 (zeige S1PR2 ELISA Kits) = sphingosine 1-phosphate receptor 2 (zeige S1PR2 ELISA Kits); PI3K (zeige PIK3CA ELISA Kits) = phosphatidylinositol 3-kinase; Akt (zeige AKT1 ELISA Kits) = proto-oncogene c-akt (zeige AKT1 ELISA Kits))
Sustained virologic response was significantly associated with SCARB1 rs10846744 in chronic hepatitis C patients, treated with pegylated interferon-alpha (zeige IFNA ELISA Kits) and ribavirin.
Model recombinant HDL (zeige HSD11B1 ELISA Kits) (rHDL) particles formed in vitro with S1P (zeige MBTPS1 ELISA Kits) incorporated into the particle initiated the internalization of S1PR1 (zeige S1PR1 ELISA Kits), whereas rHDL without supplemented S1P (zeige MBTPS1 ELISA Kits) did not, suggesting that S1P (zeige MBTPS1 ELISA Kits) transported in HDL (zeige HSD11B1 ELISA Kits) can selectively activate S1PR1 (zeige S1PR1 ELISA Kits).
Data implicate that scavenger receptor class B member 1 (SR-B1) as a target in chronic lymphocytic leukemia (CLL) and high-density lipoproteins nanoparticles (HDL (zeige HSD11B1 ELISA Kits) NPs (zeige NPS ELISA Kits)) as targeted monotherapy for CLL.
SR-B1 is a silica receptor associated with canonical inflammasome activation.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (zeige LPAR1 ELISA Kits)/3 -AKT (zeige AKT1 ELISA Kits) activation and subsequent SRBI expression.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI. This region of SR-BI harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (zeige HSD11B1 ELISA Kits) and mediate cholesterol delivery.
Carboxy-terminal deletion of SR-BI reduced receptor levels in liver and steroidogenic tissues (adrenal cortex, ovary, testicular Leydig cells) and induced hypercholesterolemia.
Loss of ScarB1 is associated with Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor (zeige LDLR ELISA Kits) Knockout Mice when fed the modified western-type diet.
We showed here that SR-BI deficiency led to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling in LDL-R KO mice fed an atherogenic diet.
The seven intron CGIs are methylated differentially in Y1 cells, mouse Leydig tumor cells, ovarian granulosa cells, and mouse liver hepa 1-6 cells; experiments raised the possibility that DNA methylation (zeige HELLS ELISA Kits) participates in hormonal regulation of SR-BI expression in a tissue-specific manner.
SR-B1, the HDL (zeige HSD11B1 ELISA Kits) receptor, is expressed abundantly in liver sinusoidal endothelial cells and marginally in hepatocytes.
SR-B1 and targeted HDL (zeige HSD11B1 ELISA Kits) NPs (zeige NPS ELISA Kits) provide a fundamental advance in studying cholesterol-dependent cellular uptake mechanisms.
Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 (zeige ABCG1 ELISA Kits) but not ABCA1 (zeige ABCA1 ELISA Kits).
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
scavenger receptor class B member 1
, scavenger receptor class B, member 1
, scavenger receptor class B type I
, high density lipoprotein receptor SR-BI
, CD36 and LIMPII analogous 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
, scavenger receptor class B type III
, HDL QTL 1
, scavenger receptor class B1
, CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1)
, scavanger receptor class B type 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1)