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Human PLAU Protein expressed in Human - ABIN491612
Reichel, Uhl, Lerchenberger, Puhr-Westerheide, Rehberg, Liebl, Khandoga, Schmalix, Zahler, Deindl, Lorenzl, Declerck, Kanse, Krombach: Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. in Circulation 2011
Zeige alle 6 Referenzen für ABIN491612
Human PLAU Protein expressed in Human Cells - ABIN2003435
Nagai, Hiramatsu, Kanéda, Hayasuke, Arimura, Nishida, Suyama: Molecular cloning of cDNA coding for human preprourokinase. in Gene 1985
Zeige alle 4 Referenzen für ABIN2003435
Human PLAU Protein expressed in Human - ABIN491028
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Mouse (Murine) PLAU Protein expressed in Insect Cells - ABIN2544534
Bryer, Fantuzzi, Van Rooijen, Koh: Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. in Journal of immunology (Baltimore, Md. : 1950) 2008
results show that the uPA (zeige PRAP1 Proteine)/uPAR (zeige PLAUR Proteine)/LRP1 (zeige LRP1 Proteine) system is a potential target for the development of therapeutic strategies to promote axonal recovery following a CNS injury
The present research concluded that aspirin suppressed prostate cancer cell invasion by reducing MMP-9 (zeige MMP9 Proteine) activity and uPA (zeige PRAP1 Proteine) expression through decreasing of IKK-beta (zeige IKBKB Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) activation, indicating that the ability of aspirin to inhibit cell invasion might be useful in the chemoprevention of metastatic prostate cancer.
These studies identify uPA (zeige PRAP1 Proteine)-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA (zeige PRAP1 Proteine) mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.
We concluded that overexpression of MMP-3 (zeige MMP3 Proteine) and uPA (zeige PRAP1 Proteine), altogether with diminished expression of PAI-1 (zeige SERPINE1 Proteine) from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer.
The up-regulation of uPA (zeige PRAP1 Proteine) mRNAs was correlated with high-risk clinicopathological features, including extrathyroid invasion, loss of cellular polarity/cohesiveness, and the BRAF (zeige BRAF Proteine)(V600E) mutation.
In contrast to platelet-derived growth factor, all urokinase isoforms induced secretion of MMP-9 (zeige MMP9 Proteine) by mesenchymal stromal cells.
Transplantation of uPA (zeige PRAP1 Proteine) gene modified mesenchymal stem cells suppressed liver fibrosis and ameliorated liver function and may be a new approach to treating liver fibrosis
ApaL1 and Taq1 single nucleotide polymorphisms of the urokinase and VDR (zeige CYP27B1 Proteine) genes are associated with recurrent urolithiasis in a Caucasian population.
1,25D3 works as a modifier of NF-kappaB (zeige NFKB1 Proteine)/GPX1 (zeige GPX1 Proteine)/uPA (zeige PRAP1 Proteine) expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells
Resveratrol inhibited hypoxia-induced HIF-1alpha (zeige HIF1A Proteine) protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (zeige PRAP1 Proteine) and MMP2 (zeige MMP2 Proteine).
These studies identify uPA-dependent de-repression of vegfr1 (zeige FLT1 Proteine) and vegfr2 (zeige KDR Proteine) gene transcription through binding to HHEX/PRH (zeige HHEX Proteine) as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF (zeige VEGFA Proteine) and identifies a potential new target for control of pathologic angiogenesis.
Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models.
GM-CSF (zeige CSF2 Proteine) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI (zeige TBPL1 Proteine).
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (zeige PLAUR Proteine))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (zeige PLAT Proteine) and/or PAI-1 (zeige SERPINE1 Proteine), rather than an altered uPA expression, determines the plasmin (zeige PLG Proteine)-mediated Abeta (zeige APP Proteine) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
beta-elemene downregulates expression of uPA, uPAR (zeige PLAUR Proteine), MMP-2 (zeige MMP2 Proteine), and MMP-9 (zeige MMP9 Proteine) in a murine intraocular melanoma model
Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (zeige PLAT Proteine)) followed by delayed synthesis and release of urokinase plasminogen (zeige PLG Proteine) activator (uPA) from injured brain.
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
Data show that urokinase-type plasminogen activator (uPA) is only expressed in the cumulus cells of immature and in vitro matured cumulus-oocyte complexes (COCs), while uPA receptor (uPAR (zeige PLAUR Proteine)) and plasminogen activator inhibitor-1 (PAI-1 (zeige SERPINE1 Proteine)) are expressed in both the cumulus cells and the immature and in vitro matured oocytes.
uPA/uPAR (zeige PLAUR Proteine) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (zeige IRF6 Proteine) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (zeige PLAUR Proteine) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (zeige PLG Proteine) activator/plasmin (zeige PLG Proteine) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (zeige SERPINE2 Proteine) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein