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Rat (Rattus) MMP 9 Protein expressed in Human Cells - ABIN3218785
Opdenakker, Van den Steen, Dubois, Nelissen, Van Coillie, Masure, Proost, Van Damme: Gelatinase B functions as regulator and effector in leukocyte biology. in Journal of leukocyte biology 2001
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Human MMP 9 Protein expressed in Human Cells - ABIN2002581
Belotti, Paganoni, Manenti, Garofalo, Marchini, Taraboletti, Giavazzi: Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation. in Cancer research 2003
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KLF9 (zeige KLF9 Proteine) could down-regulate MMP9 expression to inhibit breast cancer metastasis.
MMP-9 is one of the useful cell surface markers for the separation of angiogenic cells.
Concentrations of MMP-2 (zeige MMP2 Proteine) and MMP-9 in serum in humans measured after acute stroke are potentially influenced by extraneous covariates rather than being directly associated with characteristics of the underlying stroke
There were no differences in activities of MMP-2 (zeige MMP2 Proteine), proMMP-9, and MMP-9/NGAL (neutrophil gelatinase associated lipocalin (zeige LCN2 Proteine)) complex (gelatin substrate) in men with detected prostate cancer, although the latter two were somewhat diminished.
Data indicate that the matrix metallopeptidases MMP-2 (zeige MMP2 Proteine)/MMP (zeige MMP2 Proteine)-9 ratio provided better compromise between specificity and sensitivity in distinguishing PE from normal pregnancies, than either of the two MMPs alone.
Circulating NGAL (zeige LCN2 Proteine) and MMP-9/NGAL (zeige LCN2 Proteine) are associated with plaque vulnerability in patients with carotid artery stenosis. Statin treatment could contribute to plaque stabilization by reducing circulating NGAL (zeige LCN2 Proteine) and MMP-9/NGAL (zeige LCN2 Proteine) levels.
study revealed decreased levels of VEGF (zeige VEGFA Proteine), ANGPT1 (zeige ANGPT1 Proteine), and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 (zeige ANGPT2 Proteine) was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 (zeige ANGPT1 Proteine) level as well as MMP-9 and the time to engraftment were observed.
The presence of the T-1702A polymorphism for MMP-9 increases the risk of recurrent depressive disorder development
Our studies also provide mechanistic insight into the increased level and activity of secreted MMP-9 in cortical neurons derived from FTD (zeige FTL Proteine) patient-specific iPSCs with MAPT (zeige MAPT Proteine) mutations. The increase seems to be mediated by ERK (zeige EPHB2 Proteine)-pathway activation.
High MMP9 expression is associated with Bronchiolitis Obliterans Syndrome.
Optical imaging demonstrated increased MMP activity in TB lesions and MMP-9 was significantly expressed in cavitary lesions.
MMP-2 (zeige MMP2 Proteine) and -9 expression were suppressed significantly by treatment with SB-3CT. The data demonstrated, for the first time, that SB-3CT strongly reduced corneal lymphangiogenesis and macrophage infiltration during inflammation.
Grooved surfaces showed time-dependent increase in soluble mediators involved in cell fusion, CCL2 (zeige CCL2 Proteine) and MMP-9
A MMP-9-cleaved OPN fragment, OPN-32kDa, was responsible for inducing expansion of myeloid-derived suppressor cells, which may contribute to 3LL tumor's evasion of the immune response.
animals were submitted to the evaluation of Blood-Brain Barrier permeability and MMP-2 (zeige MMP2 Proteine) and MMP-9 in striatum, hippocampus and cerebral cortex
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Proteine) expression via E2F1 transcription factor (zeige E2F1 Proteine) 1 (zeige HNF1A Proteine), promoting Wasf3/Wave3 (zeige WASF3 Proteine)/MMP9 signaling and bladder cancer invasion
IL-33 (zeige IL33 Proteine)-induced MMP-9 expression in the mouse monocyte/macrophage line RAW264.7.
Cleavage of beta-DG still occurred when both MMP-2 (zeige MMP2 Proteine) and MMP-9 were knocked out in gamma - sarcoglycan (zeige SGCG Proteine)-deficient mice. The study found that up-regulation of MMP-14 (zeige MMP14 Proteine) is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
MMP-9's contribution to development of atherosclerotic lesions may be a direct stimulation of endothelial cells, and that PAR-1 (zeige MARK2 Proteine) may serve as a receptor for MMP-9.
Results show that ablation of systemic MMP-9 initiated fatal communication between maintenance of physiological functions of MMP-9 in the bone marrow and invasive growth of pancreatic ductal adenocarcinoma via the deregulation of IL6 (zeige IL6 Proteine).
Increased MMP-9 expression is associated with carotid atherosclerotic plaque.
Increased expression of MMP-9 is associated with intraplaque hemorrhage in a swine model of vulnerable carotid atherosclerosis
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9, TIMP1 (zeige TIMP1 Proteine), and NGAL (zeige LCN2 Proteine) (also MMP2 (zeige MMP2 Proteine) in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 (zeige MMP2 Proteine) and MMP9 are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 and MMP-2 (zeige MMP2 Proteine), caspase-3 (zeige CASP3 Proteine) and BDNF (zeige BDNF Proteine)
Oxygen for newborn resuscitation increases MMP-2 (zeige MMP2 Proteine)/-9 activity resulting in tissue damage and influencing remodeling processes.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (zeige CSF2 Proteine) barrier in vitro
The levels of matrix metalloproteinase-2 (zeige MMP2 Proteine) and matrix metalloproteinase-9 (MMP-9)in the corpus luteum of swine during luteolysis are reported.
Our data define pericyte interactions as a main inducer of endothelial MMP secretion and propose a new role for pericyte-endothelial cell crosstalk at the BBB in vitro
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 (zeige CCL2 Proteine) and Lp-PLA(2 (zeige Lp-PLA2 Proteine)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.
In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.
These data demonstrate that serum neutrophil haptoglobin (zeige HP Proteine)-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
Activation of cytosolic MMP-9 and MMP-2 (zeige MMP2 Proteine) was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Role of TGF-beta1 (zeige TGFB1 Proteine) and TNF-alpha (zeige TNF Proteine) in IL-1beta (zeige IL1B Proteine) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Decreased MMP-9 and increased TIMP-1 (zeige TIMP1 Proteine) expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.
We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (zeige EGF Proteine) on MMP-9 and TIMP-1 (zeige TIMP1 Proteine) expression by semiquantitative RT-PCR and MMP activity by zymography.
results suggest a significant role of matrix metalloproteinase-2 (zeige MMP2 Proteine) and-9 in growth and development of bovine follicle
Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha (zeige TNF Proteine), hepatocyte growth factor (zeige HGF Proteine), and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2.
MMP-2 and MMP-9 production in blastocysts attached to the endometrial cells is regulated by TNF-alpha and TNF-beta
Results suggest that MMP-2 (zeige MMP2 Proteine), MMP-9, and TIMP-2 (zeige TIMP2 Proteine) mRNAs are expressed in bovine placentomes during the gestational and postpartum periods and that these enzymes, in conjunction with steroidogenic enzymes, mediate fetal membrane detachment after parturition.
The findings of this study suggest that Mmp-9 is a protective molecule against infection by Listeria monocytogenes by engaging in migration of zebrafish macrophages to the site of infection via a non-proteolytic role.
elevated beta-oxidation-fuelled mitochondria-derived reactive oxygen species within epidermal cells helps guide matrix metalloproteinase-driven leukocyte recruitment.
Mmp9 regulates both acute and chronic tissue damage and plays an essential role in collagen reorganization during wound repair.
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 and Mmp13 (zeige MMP13 Proteine).
study identified mechanism by which mycobacteria induce granulomas: ESAT-6 induced MMP9 in epithelial cells neighboring infected macrophages; MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation & bacterial growth
From 24h post fertilization, mmp9 expression was detected in a population of circulating white blood cells.
expression and activity of MMP-2 (zeige MMP2 Proteine) and MMP-9 in the embryonic zebrafish.
The MMP-9 gene was duplicated and differentiated into two genes, one was specialized in a common ancestor of X. laevis and X. tropicalis expressed in degenerating and remodeling organs in response to thyroid hormone (zeige PTH Proteine) during metamorphosis.
MMP-9TH is responsible in the larval epithelial apoptosis through degrading ECM (zeige MMRN1 Proteine) components in the basal lamina, whereas MMP-9 is involved in the removal of dying epithelial cells during amphibian intestinal remodeling
metamorphic tail and intestine RNA levels of TIMP-2 (zeige TIMP2 Proteine), MT1-MMP (zeige MMP14 Proteine) and Gel-A, but not MT3-MMP (zeige MMP24 Proteine) or TIMP-3 (zeige TIMP3 Proteine), are elevated during periods of cell death and proliferation
Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.
Inflammatory factors such as TNF-alpha (zeige TNF Proteine) can stimulate MMP-2 (zeige MMP2 Proteine)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Therefore, it was reasonable to speculate that the increased expression of VEGF (zeige VEGFA Proteine) and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.
Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (zeige MMP2 Proteine), MMP-9 and TIMP-1 (zeige TIMP1 Proteine) in rabbits with acute paraquat poisoning.
In experimental syringomyelia, MMP-9 plays an important role in causing edema in the presyrinx state.
Tongxinluo can inhibit the expression of MMP-3 (zeige MMP3 Proteine) and 9 and increase the expression of PPARgamma (zeige PPARG Proteine) in atherosclerotic rabbits.
TGF-beta (zeige TGFB1 Proteine) mediated MMP-9 induction may be regulated by the NF-kappaB (zeige NFKB1 Proteine), Smad3 (zeige SMAD3 Proteine), and JNK (zeige MAPK8 Proteine) pathways, whereas the IL-1beta (zeige IL1B Proteine) mediated induction may be regulated by the NF-kappaB (zeige NFKB1 Proteine) and p38 (zeige MAPK14 Proteine) pathways.
The results showed that MMP-2 (zeige MMP2 Proteine), MMP-9, and StAR were significantly expressed in the granulosa and thecal cells of the ovarian atretic follicles during proestrus, and were strongly expressed in the corpus luteum during metestrus.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
92 kDa gelatinase
, 92 kDa type IV collagenase
, macrophage gelatinase
, matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, matrix metalloproteinase-9
, type V collagenase
, 92kD gelatinase
, 92kD type IV collagenase
, 92kDa gelatinase
, 92kDa type IV collagenase
, Gel B
, collagenase type IVB
, gelatinase B
, matrix metalloproteinase 9
, 92-kDa type IV collagenase
, matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase)
, matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase)
, type IV collagenase MMP-9
, Matrix metalloproteinase-9
, matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
, 75 kDa gelatinase