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Human LCN2 Protein expressed in - ABIN621226
Wang, Liu, Meng, Liu, Wang, Li, Cui, Meng, Hu, Wei: Up-regulated lipocalin-2 in pulmonary hypertension involving in pulmonary artery SMC resistance to apoptosis. in International journal of biological sciences 2014
The results of the present study suggest that even if NGAL values mildly rose after competition, no kidney injury occurred in these highly trained athletes during mountain stages of professional competitions.
In children after renal transplantation, urinary NGAL cannot be used as a specific marker for distinguishing acute rejection from other non-rejection causes of AKI. Urinary NGAL was mainly associated with graft function but not with the etiology of AKI.
The amniochorion is a source of NGAL and similarly to other inflammatory conditions, this protein may augment the collagenolytic effect of MMP-9 (zeige MMP9 Proteine) and modulate host-microbe interactions in pregnancies complicated by intra-amniotic infection/inflammation.
Our findings collectively support a potential role of LCN2 in cancer cell invasion through the epithelial-to- mesenchymal transition pathway and suggest that LCN2 could be effectively utilized as a lymph node metastasis marker in cervical cancer.
We conclude that low BDNF (zeige BDNF Proteine) and high LCN2 and NF-L (zeige NEFL Proteine) levels are associated with Multiple Sclerosis (MS) pathogenesis, and high IGFBP1level is a biomarker for female MS only, suggesting different MS progression pathways between the sexes. LCN2 is a candidate predictor of response to natalizumab treatment, and NF-L (zeige NEFL Proteine) is a candidate predictor of clinically isolated syndrome's (CIS (zeige CISH Proteine)) conversion into MS.
Ascites NGAL level may be a biomarker of peritonitis in hospitalized patients with cirrhosis and an independent predictor of short-term in-hospital mortality.
Circulating NGAL and MMP-9 (zeige MMP9 Proteine)/NGAL are associated with plaque vulnerability in patients with carotid artery stenosis. Statin treatment could contribute to plaque stabilization by reducing circulating NGAL and MMP-9 (zeige MMP9 Proteine)/NGAL levels.
our findings indicated that LCN2 negatively modulated proliferation, EMT (zeige ITK Proteine) and energy metabolism in colorectal cancer (CRC (zeige CALR Proteine)) cells. Accordingly, LCN2 may be a candidate metastasis suppressor and potential therapeutic target in CRC (zeige CALR Proteine)
High plasma NGAL correlates with high mortality and myocardial dysfunction in severe sepsis and septic shock.
The analysis showed higher urinary NGAL and urinary ATF3 (zeige ATF3 Proteine) in patients with sepsis-AKI in comparison with patients with sepsis-non-AKI and healthy volunteers.
Knockout of Lcn2 attenuated tumor-associated lymphangiogenesis and breast tumor metastasis
Overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in polycystic kidney disease mice, and was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits abdominal aortic aneurysm expansion in mice by decreasing neutrophil infiltration in the aorta.
Results suggest that blood brain barrier leakage occurs in white matter after subarachnoid hemorrhage (SAH (zeige ACSM3 Proteine)) and that LCN2 contributes to SAH (zeige ACSM3 Proteine)-induced blood brain barrier disruption.
LCN2 overexpression in bones modifies the bone marrow microenvironment via modulation of the expression of key secreted factors and cytokines, which in turn regulate the hematopoietic stem cell niche behavior enhancing both HSC (zeige FUT1 Proteine) homing in young mice and erythrocytes production in older mice.
LCN2 modulated the secretion of proinflammatory cytokines in PSC of the PDAC tumor microenvironment, whereas downregulation of LCN2-specific receptor SLC22A17 (zeige SLC22A17 Proteine) blocked these effects. Our results reveal how LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC development.
results identify lipocalin 2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R (zeige MC4R Proteine)-dependent manner, and show that the control of appetite is an endocrine function of bone
Lcn2 can suppress the beneficial cardiac autophagic response to ischemia and that this contributes to enhanced ischemia-induced cell death and cardiac dysfunction.
Plasma levels of LCN2 measured in patients one week after ischemic stroke contribute to the prediction of clinical outcome at 90 days and reflect the systemic response to post-stroke infections
may potentiate the development of psoriasis via the enhancement of Th17- and antimicrobial peptide (zeige cAMP Proteine)-mediated inflammation
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (zeige MMP9 Proteine), TIMP1 (zeige TIMP1 Proteine), and NGAL (also MMP2 (zeige MMP2 Proteine) in 220 kDa complex) without proteolytic activity.
porcine p25alpha (zeige Tppp Proteine) is heavily modified with a variety of modifications: phosphorylation, di- and trimethylation, citrullination and a HexNAc group.
mouse homolog plays a role in IL3 withdrawal-induced apoptosis
, lipocalin 2 (oncogene 24p3)
, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
, migration-stimulating factor inhibitor
, neutrophil gelatinase-associated lipocalin
, oncogene 24p3
, siderocalin LCN2
, SV-40-induced 24P3 protein
, secreted inducible protein 24
, alpha-2-microglobulin-related protein
, alpha-2U globulin-related protein