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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988022
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
The genotype and allele distribution of IL-10 (-A592C) gene polymorphism was significantly different between OSCC cases and controls (genotype AA vs AC: OR 2.87; 95 % CI 1.50-5.48; p = 0.0016 and AA vs CC: OR 4.08; 95 % CI 1.98-8.41; p = 0.0002). The -592 C alleles were found to be significantly different among OSCC cases and controls (OR: 1.44, 95% CI: 1.12-1.85, p < 0.0051).
this study reveals a key role of IL-10 in controlling cellular metabolism via inhibiting mTORC1, and this metabolic control by IL-10 is critical to control of inflammation.
This review summarizes the paradoxic effects of IL-10 on different types of immune responses, and proposes that different cellular sources of IL-10, in particular IL-10-secreting helper and regulatory T-cells, have different effects on B-cell and CTL responses. Based on this concept we discuss the rationales for targeting the IL-10 pathway in immune-mediated diseases and cancer.
Meta-analysis provides evidence that IL-10 gene rs1800896 polymorphism is associated with the risk of acute pancreatitis.
We believe that current findings derived from human and mouse experiments will promote the development of new drugs and therapies based on IL-10 modulation, which may enhance host immunity and bacterial clearance during infection. However, because IL-10 can play both favorable and unfavorable effects over the host depending on the bacterial infection, it may act as a double edge sword.
IL-10 -592 A/C polymorphism is associated with cognitive dysfunction in first-episode drug-naive schizophrenia.
the production of IL-10 in Th2 cells was higher in the patients with sepsis
Our observations suggested that IL-10 -592 A/C, -1082 G/A, and IFN-gamma (zeige IFNG Proteine) +874 T/A polymorphisms had a strong association with susceptibility to HCV infection. However, no significant association was observed between the cytokines (IL-10 and IFN-gamma (zeige IFNG Proteine)) genotypes profile and HCV-liver cirrhosis risk in the studied population, except for the high frequency of IFN-gamma (zeige IFNG Proteine) +874 T allele in cirrhotic patients.
searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis
studies demonstrated that ovarian cancer cells isolated from patients with type II tumors released high levels of immunosuppressive cytokines (i.e., interleukin 10 and transforming growth factor beta) and HspA1A (zeige HSPA1A Proteine) in vitro.
Mechanistic studies suggest a PKC-Syk (zeige SYK Proteine)-mediated signaling pathway, to which IL-10 conversely inhibits, is required for activating macrophage self-targeting, followed by phagocytosis independent of calreticulin (zeige CALR Proteine) Moreover, we identified spleen red pulp to be one specific tissue that provides stimuli constantly activating macrophage phagocytosis albeit lacking in Cd47 (zeige CD47 Proteine)(-/-) or Sirpalpha(-/-) mice.
High IL10 expression is associated with lung cancer.
The activation of STAT3 (zeige STAT3 Proteine) was much higher in Gal12 (zeige LGALS12 Proteine)(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10. Adipocytes showed higher insulin (zeige INS Proteine) sensitivity when treated with Gal12 (zeige LGALS12 Proteine)(-/-) macrophage-conditioned media than those treated with Gal12 (zeige LGALS12 Proteine)(+/+) macrophages.
IL-10-MSCs offered superior protection against LPS (zeige TLR4 Proteine)-induced ALI.
methane-rich saline may activate the PI3K-AKT (zeige AKT1 Proteine)-GSK-3beta pathway to induce IL-10 expression and produce anti-inflammatory effects via the NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) pathways. The findings provide a new pharmacological strategy for management of inflammatory response after acute liver injury.
plasma adiponectin and leptin (zeige LEP Proteine) were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism
IL-12p35 suppresses lymphocyte proliferation, induces expansion of IL-10-expressing and IL-35-expressing B cells and ameliorates autoimmune uveitis.
aerobic interval training enhanced the anti-inflammatory indices IL-10/TNF-alpha (zeige TNF Proteine) ratio and IL-15 (zeige IL15 Proteine) expression in skeletal muscle in tumor-bearing mice.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (zeige TLR4 Proteine) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (zeige SOCS3 Proteine), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (zeige IL6 Proteine):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (zeige ICAM1 Proteine) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10, and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (zeige IFNG Proteine)+CD4 (zeige CD4 Proteine)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (zeige MAPK14 Proteine) activation.
Boar seminal plasma contained TGF- beta1 (zeige TGFB1 Proteine) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10, but not IL-6 (zeige IL6 Proteine), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (zeige CRP Proteine) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (zeige NTS Proteine), which may contribute to differences in the clinical presentation of NTS (zeige NTS Proteine) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (zeige TNF Proteine) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor