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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988022
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
this study shows association of interleukin-10 polymorphisms with risk factors of Alzheimer's disease and other dementias in a Mexican population
Dysfunction of CD24 (zeige CD24 Proteine)+CD38+ B cells in patients with Hashimoto's thyroiditis is associated with a lack of interleukin 10
IL-10, IL-17 (zeige IL17A Proteine) and IP-10 (zeige CXCL10 Proteine) response to tubercular antigens act as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects.
In the present study, we comprehensively investigated the variants in introns, UTRs, and the promoter region of IL10 and identified no association between any of these variants and Vogt-Koyanagi-Harada (VKH) disease.
Results show that IL-10-driven metabolic rheostat maintains metabolic equilibrium during M1 macrophage differentiation and that perturbation of this regulatory loop, either directly by exogenous cellular sources of IL-10 or indirectly via limitations in glucose availability, skews the cellular metabolic program altering the balance between inflammatory and immunosuppressive phenotypes.
Results from these two large randomized aerobic exercise intervention trials suggest that aerobic exercise does not alter IL-10 or IL-4 (zeige IL4 Proteine) in a manner consistent with chronic disease and cancer prevention.
IL-2 (zeige IL2 Proteine) and IL-10 could work synergistically to improve the survival, proliferation, and cytotoxicity of activated CD8 (zeige CD8A Proteine)(+) T cells, an effect suppressible by CD4 (zeige CD4 Proteine)(+)CD25 (zeige IL2RA Proteine)(+) Treg cells
Patients with Mycoplasma pneumoniae pneumonia had lower interleukin-10 levels than patients with respiratory syncytial virus pneumonia who had interleukin-10 levels comparable to those of patients with bacterial pneumonia, indicating a significant difference in the interleukin-6 (zeige IL6 Proteine)/interleukin-10 ratio between patients with Mycoplasma pneumoniae pneumonia and respiratory syncytial virus pneumonia.
These findings provide evidence supporting the role of PTX3 (zeige PITX3 Proteine) as a mediator of the anti-inflammatory response in physiologically relevant conditions, and suggests that PTX3 (zeige PITX3 Proteine) counter regulates the development of atherosclerosis by enhancing the production of IL-10.
Single nucleotide polymorphism in IL10 gene is associated with susceptibility to HPV-16 positive cervical cancer.
this study shows that Influenza A virus-induced release of IL-10 inhibits the anti-microbial activities of invariant natural killer T cells during invasive pneumococcal superinfection
Data show that two functionally distinct cytokines, interleukin-4 (IL-4 (zeige IL4 Proteine)) and interferon-gamma (IFN-gamma (zeige IFNG Proteine)), significantly potentiate the ability of mesenchymal stem cells (MSCs) to inhibit interleukin-10 (IL-10) production by activated regulatory B cells (Bregs).
The anti-inflammatory functions of p38 MAPK (zeige MAPK14 Proteine) in macrophages are critically dependent on production of IL-10.
Pretreating mice with carrageenan once a day before injecting LPS (zeige TLR4 Proteine) increased the levels of IL-10 by 2.5-fold and reduced TNF-alpha (zeige TNF Proteine) production by 2-fold compared with control. So, kappa/beta-carrageenan alone and in combination with LPS (zeige TLR4 Proteine) enhanced the cellular activity and mobility of peritoneal macrophages by increasing cell adhesion and migration compared with control.
results demonstrate that IL-10-producing interstitial macrophages negatively regulate Th2- and Th17-mediated inflammatory responses, helping prevent neutrophilic asthma
Antigen targeting to DEC-205 (zeige LY75 Proteine) on dendritic cells leads to an IL-10-dependent downregulation of CXCR3 (zeige CXCR3 Proteine) expression on differentiated antigen-specific Th1 (zeige HAND1 Proteine) cells in vivo. This downregulation interferes with the migration of Th1 (zeige HAND1 Proteine) cells into the gut (zeige GUSB Proteine) and protects mice against severe acute and relapsing intestinal inflammation.
The investigation of the IL-10R complex revealed that both the extracellular and intracellular domains of IL-10R2 (zeige IL10RB Proteine) influence the conformation of IL-10R1 (zeige IL10RA Proteine) and that both domains were required for transducing IL-10 signals.
identification of the Mediator-associated kinase CDK8 (zeige CDK8 Proteine), and its paralog CDK19 (zeige CDK19 Proteine), as negative regulators of IL-10 production during innate immune activation
ablation of IL-10 signaling in Th2 cells led to enhanced Th2 cell survival and exacerbated pulmonary inflammation in a murine model of house dust mite allergy
Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (zeige TLR4 Proteine) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (zeige SOCS3 Proteine), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (zeige TH1L Proteine) biased, interferon-gamma (zeige IFNG Proteine) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (zeige IL6 Proteine):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (zeige IL6 Proteine), IL-10 and TNF-alpha (zeige TNF Proteine), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (zeige ICAM1 Proteine) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (zeige JUN Proteine) may be responsible for this upregulation.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (zeige TGFB1 Proteine), IL-10, and IL-6 (zeige IL6 Proteine) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (zeige IFNG Proteine)+CD4 (zeige CD4 Proteine)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (zeige MAPK14 Proteine) activation.
Boar seminal plasma contained TGF- beta1 (zeige TGFB1 Proteine) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (zeige TNF Proteine) and IL-10, but not IL-6 (zeige IL6 Proteine), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (zeige CRP Proteine) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (zeige NTS Proteine), which may contribute to differences in the clinical presentation of NTS (zeige NTS Proteine) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (zeige TNF Proteine) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor