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HNP1 upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (zeige NFKB1 Proteine) activation or knockdown of IRF1 (zeige IRF1 Proteine), demonstrating the importance of these two signaling events in HNP1-induced pDC (zeige PNKD Proteine) activation.
these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (zeige ADAMTS13 Proteine) activity, likely by binding to the central A2 domain of VWF (zeige VWF Proteine) and physically blocking ADAMTS13 (zeige ADAMTS13 Proteine) binding.
Increased alpha-defensin (zeige DEF Proteine) expression is associated with risk of coronary heart disease in hyperlipidemia patients.
Levels in sera and CSF (zeige CSF2 Proteine) were elevated in Alzheimer disease patients compared with controls.
the decreased HNP-1 production in the polymorphonuclear phagocytes form elderly individuals might have an important participation in the increased susceptibility to infectious diseases.
Increased levels of neutrophil defensin 1, apolipoprotein E (zeige APOE Proteine), clusterin (zeige CLU Proteine), and zinc-alpha-2-glycoprotein (zeige AZGP1 Proteine) are present in carotid atherosclerotic plaque secretomes.
HNP1 functions as a "molecular brake" on macrophage-driven inflammation, ensuring both pathogen clearance and the resolution of inflammation with minimal bystander tissue damage.
HP1 binding to the chromosomal passenger complex becomes particularly important when Aurora B (zeige AURKB Proteine) phosphorylates kinetochore targets to eliminate erroneous microtubule attachments
data demonstrate that HNP-1 induces IL-8 production not only through P2Y6, but also through additional P2 receptors via an ERK1/2-dependent mechanism in intestinal epithelial cells.
Results showed that NO and NaNO2 can be considered as factors regulating the chemoattractant properties of defensin (zeige DEF Proteine) HNP1 in neutrophils
Decreased alpha-defensin (zeige DEF Proteine) is associated with intestinal inflammation in a model of inflammatory bowel disease.
cryptdin-1 and cryptdin-4 exhibit circadian oscillation
the Arg5-Glu13 salt bridge in alpha-defensin (zeige DEF Proteine) is conserved for defensin (zeige DEF Proteine) in vivo stability
MMP-7 (zeige MMP7 Proteine) activates mouse paneth cell pro-alpha-defensins
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
defensin, alpha 1, myeloid-related sequence
, defensin, alpha 2
, myeloid-related sequence
, neutrophil defensin 1
, alpha-defensin 1
, defensin related cryptdin peptide 1
, defensin-related cryptdin peptide
, defensin alpha 1
, Paneth cell-specific alpha-defensin 2
, alpha-defensin 5, Paneth cell-specific
, defensin NP-2
, neutrophil antibiotic peptide NP-1
, neutrophil antibiotic peptide NP-2
, neutrophil defensin 2
, Neutrophil defensin 1
, Neutrophil defensin 3
, neutrophil defensin 8