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Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (zeige APOA1 Proteine) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (zeige HSD11B1 Proteine) biogenesis.
there is an NFATc1 (zeige NFATC1 Proteine)/ABCA1-dependent mechanism in which local TNF (zeige TNF Proteine) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (zeige TNF Proteine), TNFR1 (zeige TNFRSF1A Proteine), or TNFR2 (zeige TNFRSF1B Proteine) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.
ABCB1 (zeige ABCB1 Proteine) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer
ABCA1 mediates ApoA-I (zeige APOA1 Proteine) and ApoA-I (zeige APOA1 Proteine) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.
EEPD1 is a novel LXR (zeige NR1H3 Proteine)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.
This is the first report showing evidence of FTO (zeige FTO Proteine) and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences
Pim (zeige PIM1 Proteine)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (zeige NR1H2 Proteine) and subsequent stabilization of the ABCA1-Pim (zeige PIM1 Proteine)-1L complex and thereby regulates the circulating level of high-density lipoprotein.
High expression of ABCA1 is associated with high carotid intima-media thickness.
our results highlight the importance of the LXR (zeige NR1H3 Proteine)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Proteine) or ABCG1 (zeige ABCG1 Proteine) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (zeige HSD11B1 Proteine) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (zeige PCSK9 Proteine) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (zeige APOA1 Proteine)/ABCA1-mediated cholesterol efflux without STAT3 (zeige STAT3 Proteine) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (zeige NR1H3 Proteine)-ABCA1/ABCG1 (zeige ABCG1 Proteine) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 Proteine)-C levels observed in patients receiving both medications
The findings obtained from apoE (zeige APOE Proteine)-/- mice provide epigenetic insights into how EZH2 (zeige EZH2 Proteine) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (zeige EZH2 Proteine) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ARF6 (zeige ARF6 Proteine)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (zeige ARF6 Proteine)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1