ABCA1 Proteine (ABCA1)

Bezeichnung:
ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 Proteine (ABCA1)
Auf www.antikoerper-online.de finden Sie aktuell 8 ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ABCA1 Antikörper (194) und ABCA1 Kits (42) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 247 ABCA1 Produkte verfügbar.
Synonyme:
ABC-1, Abc1, ABCA1, Arabidopsis thaliana ATP-binding cassette A1, AtABCA1, ATP-binding cassette A1, CERP, HDLDT1, TGD
alle Proteine anzeigen Gen GeneID UniProt
ABCA1 19 O95477
Ratte ABCA1 ABCA1 313210  
ABCA1 11303 P41233

Weitere Synonyme anzeigen

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Weitere Proteine zu ABCA1 Interaktionspartnern

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaktionspartner

  1. our results highlight the importance of the LXR (zeige NR1H3 Proteine)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.

  2. The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.

  3. Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Proteine) or ABCG1 (zeige ABCG1 Proteine) but not ABCA1.

Rabbit ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaktionspartner

  1. CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaktionspartner

  1. Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.

  2. Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.

  3. ABCB1 (zeige ABCB1 Proteine) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer

  4. ABCA1 mediates ApoA-I (zeige APOA1 Proteine) and ApoA-I (zeige APOA1 Proteine) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.

  5. EEPD1 is a novel LXR (zeige NR1H3 Proteine)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.

  6. This is the first report showing evidence of FTO (zeige FTO Proteine) and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences

  7. Pim (zeige PIM1 Proteine)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (zeige NR1H2 Proteine) and subsequent stabilization of the ABCA1-Pim (zeige PIM1 Proteine)-1L complex and thereby regulates the circulating level of high-density lipoprotein.

  8. High expression of ABCA1 is associated with high carotid intima-media thickness.

  9. Thyrotropin regulated cholesterol content and ABCA1 expression in hepG2 cells.

  10. This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to coronary heart disease (CHD (zeige CHDH Proteine)) while the CRP (zeige CRP Proteine) +1059G/C polymorphism appears to have no correlation with susceptibility to CHD (zeige CHDH Proteine).

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaktionspartner

  1. apoA-I (zeige APOA1 Proteine)/ABCA1-mediated cholesterol efflux without STAT3 (zeige STAT3 Proteine) activation can reduce proinflammatory cytokine expression in macrophages.

  2. Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (zeige NR1H3 Proteine)-ABCA1/ABCG1 (zeige ABCG1 Proteine) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 Proteine)-C levels observed in patients receiving both medications

  3. The findings obtained from apoE (zeige APOE Proteine)-/- mice provide epigenetic insights into how EZH2 (zeige EZH2 Proteine) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (zeige EZH2 Proteine) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.

  4. Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.

  5. Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.

  6. ABCA1 mediates ApoA-I (zeige APOA1 Proteine) and ApoA-I (zeige APOA1 Proteine) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.

  7. ARF6 (zeige ARF6 Proteine)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (zeige ARF6 Proteine)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.

  8. EEPD1 is a novel LXR (zeige NR1H3 Proteine)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.

  9. Pim (zeige PIM1 Proteine)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (zeige NR1H2 Proteine) and subsequent stabilization of the ABCA1-Pim (zeige PIM1 Proteine)-1L complex and thereby regulates the circulating level of high-density lipoprotein.

  10. Nucleolin (zeige NCL Proteine) protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 expression.

Pig (Porcine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaktionspartner

  1. ABCA1 promoter variants affect transcription activity and plasma HDL (zeige HSD11B1 Proteine) level in pigs

  2. ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.

  3. Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia

ABCA1 Protein Überblick

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Alternative names and synonyms associated with ABCA1

  • ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
  • ATP-binding cassette, subfamily A (ABC1), member 1 (Abca1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (abca1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1)
  • ABC transporter A family member 1 (ABCA1)
  • ABC-1 Protein
  • Abc1 Protein
  • ABCA1 Protein
  • Arabidopsis thaliana ATP-binding cassette A1 Protein
  • AtABCA1 Protein
  • ATP-binding cassette A1 Protein
  • CERP Protein
  • HDLDT1 Protein
  • TGD Protein

Bezeichner auf Proteinebene für ABCA1

ATP-binding cassette sub-family A member 1 , ATP-binding cassette transporter A1 , cholesterol efflux regulatory protein , membrane-bound , ATP-binding cassette, sub-family A (ABC1), member 1 , ATP-binding cassette, sub-family A member 1 , ATP-binding cassette transporter 1 , Cholesterol efflux regulatory protein , ATP-binding cassette transporter , ATP-binding cassette, sub-family A member 1-like , ATP-binding cassette sub-family A member 1-like , ATP-binding cassette 1

GENE ID SPEZIES
19 Homo sapiens
313210 Rattus norvegicus
373945 Gallus gallus
464630 Pan troglodytes
481651 Canis lupus familiaris
535379 Bos taurus
716107 Macaca mulatta
100013781 Monodelphis domestica
100152112 Sus scrofa
100356765 Oryctolagus cuniculus
100441342 Pongo abelii
100483394 Ailuropoda melanoleuca
100491942 Xenopus (Silurana) tropicalis
11303 Mus musculus
100557081 Anolis carolinensis
818768 Arabidopsis thaliana
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