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anti-Human ABCA1 Antikörper:
anti-Rat (Rattus) ABCA1 Antikörper:
anti-Mouse (Murine) ABCA1 Antikörper:
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Chicken Polyclonal ABCA1 Primary Antibody für ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. in Journal of lipid research 2004
Show all 253 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody für ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. in The Journal of biological chemistry 2002
Show all 13 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody für ELISA, IHC (fro) - ABIN268848
Murthy, Born, Mathur, Field: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. in Journal of lipid research 2002
Show all 13 Pubmed References
Mouse (Murine) Monoclonal ABCA1 Primary Antibody für IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. in PLoS ONE 2009
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Human Polyclonal ABCA1 Primary Antibody für WB - ABIN3044206
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
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Human Polyclonal ABCA1 Primary Antibody für WB - ABIN3043773
Chen: Effects of Chinese Herbal Compound "Xuemai Ning"on Rabbit Atherosclerosis Model and Expression of ABCA1. in International journal of biomedical science : IJBS 2013
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Human Monoclonal ABCA1 Primary Antibody für CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. in American journal of physiology. Renal physiology 2009
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Mouse (Murine) Monoclonal ABCA1 Primary Antibody für WB - ABIN188209
Prasanthi, Huls, Thomasson, Thompson, Schommer, Ghribi: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. in Molecular neurodegeneration 2009
Mouse (Murine) Monoclonal ABCA1 Primary Antibody für FACS, IF - ABIN2477218
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. in Pflügers Archiv : European journal of physiology 2007
Hepatic free cholesterol content was significantly increased in NASH (zeige SAMSN1 Antikörper) as compared to non-NASH (zeige SAMSN1 Antikörper) subjects, while ABCA1 and ABCG1 (zeige ABCG1 Antikörper) protein levels significantly decreased with NASH (zeige SAMSN1 Antikörper) and fibrosis progression. The relative expression of miR (zeige MLXIP Antikörper)-33a and miR (zeige MLXIP Antikörper)-144 correlated inversely with ABCA1 but not with ABCG1 (zeige ABCG1 Antikörper) protein levels. miR (zeige MLXIP Antikörper)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (zeige SAMSN1 Antikörper) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (zeige ABCB6 Antikörper) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages.
AMPK (zeige PRKAA1 Antikörper) activates LXRalpha (zeige NR1H3 Antikörper) and ABCA1 expression in human macrophages
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (zeige APOA1 Antikörper) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (zeige HSD11B1 Antikörper) biogenesis.
there is an NFATc1 (zeige NFATC1 Antikörper)/ABCA1-dependent mechanism in which local TNF (zeige TNF Antikörper) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (zeige TNF Antikörper), TNFR1 (zeige TNFRSF1A Antikörper), or TNFR2 (zeige TNFRSF1B Antikörper) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.
ABCB1 (zeige ABCB1 Antikörper) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer
ABCA1 mediates ApoA-I (zeige APOA1 Antikörper) and ApoA-I (zeige APOA1 Antikörper) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.
our results highlight the importance of the LXR (zeige NR1H3 Antikörper)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Antikörper) or ABCG1 (zeige ABCG1 Antikörper) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (zeige HSD11B1 Antikörper) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (zeige PCSK9 Antikörper) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (zeige APOA1 Antikörper)/ABCA1-mediated cholesterol efflux without STAT3 (zeige STAT3 Antikörper) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (zeige NR1H3 Antikörper)-ABCA1/ABCG1 (zeige ABCG1 Antikörper) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 Antikörper)-C levels observed in patients receiving both medications
The findings obtained from apoE (zeige APOE Antikörper)-/- mice provide epigenetic insights into how EZH2 (zeige EZH2 Antikörper) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (zeige EZH2 Antikörper) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 (zeige ABCG1 Antikörper) are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase (zeige NOS Antikörper) activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ARF6 (zeige ARF6 Antikörper)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (zeige ARF6 Antikörper)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1