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findings provide evidence that endogenous APE1 (zeige APEX1 ELISA Kits) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury
HAP1 co-localizes with synapsin I (zeige SYN1 ELISA Kits) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (zeige APEX1 ELISA Kits) redox function leads to an increased cell surface retention of IL-12 (zeige IL12A ELISA Kits) and enhances Th1 (zeige HAND1 ELISA Kits) responses.
findings suggest that Hap1 is important for insulin (zeige INS ELISA Kits) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (zeige CACNA1C ELISA Kits), providing new insight into the mechanisms that regulate insulin (zeige INS ELISA Kits) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (zeige THOC4 ELISA Kits)/Nrf2 (zeige NFE2L2 ELISA Kits) signalling pathway.
Results show the stimulatory effect of PARP-1 (zeige PARP1 ELISA Kits) on APE1 (zeige APEX1 ELISA Kits)-dependent base excision repair (BER). PARP-1 (zeige PARP1 ELISA Kits) and APE1 (zeige APEX1 ELISA Kits) appear to have a functional interaction in BER since PARP-1 (zeige PARP1 ELISA Kits) can stimulate the strand incision activity of APE1 (zeige APEX1 ELISA Kits).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (zeige BCR ELISA Kits) on microtubules to regulate neuronal differentiation.
increases in APEX1 (zeige APEX1 ELISA Kits) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (zeige APEX1 ELISA Kits) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (zeige APEX1 ELISA Kits) expression.
HAP1 (zeige APEX1 ELISA Kits) is expressed in endocrine cells of the human gut (zeige GUSB ELISA Kits).
data fully support that HAP1 (zeige APEX1 ELISA Kits) is a GKAP (zeige DLGAP1 ELISA Kits), anchoring specifically to the cGMP-dependent protein kinase (zeige CDK7 ELISA Kits) isoform Ibeta, and provide further evidence that also PKG (zeige PRKG1 ELISA Kits) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (zeige APEX1 ELISA Kits) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (zeige APEX1 ELISA Kits) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (zeige APEX1 ELISA Kits) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (zeige APEX1 ELISA Kits) co-localizes and associates with APP (zeige APP ELISA Kits) in physiological conditions of mouse and human brain.
WT HTT (zeige HTT ELISA Kits) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (zeige PCM1 ELISA Kits)).
HAP1 (zeige APEX1 ELISA Kits)/stigmoid body interacts with the normal ataxin-3 (zeige ATXN3 ELISA Kits) through Josephin (zeige ATXN3 ELISA Kits) domain
sortilin (zeige SORT1 ELISA Kits) stabilizes the proBDNF.HAP1 complex
ADORA2A (zeige ADORA2A ELISA Kits), but not HAP1 (zeige APEX1 ELISA Kits) or OGG1 (zeige OGG1 ELISA Kits), may have a role in age at onset in Huntington's disease
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)