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We identified three new CRC (zeige CALR ELISA Kits) risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3 (zeige POLD3 ELISA Kits); P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)).
Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis.
Shroom2 and ZO-1 (zeige TJP1 ELISA Kits) form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa (zeige MYO7A ELISA Kits), that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions.
The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome.
shroom family member 2
, apical protein of Xenopus-like
, protein Shroom2
, protein Apxl
, protein Shroom2-like
, APX homolog of Xenopus
, apical-like protein
, liver regeneration-related protein LRRG167