Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human RAB13 Antikörper:
anti-Mouse (Murine) RAB13 Antikörper:
anti-Rat (Rattus) RAB13 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal RAB13 Primary Antibody für ICC, IF - ABIN4348882
Abou-Zeid, Pandjaitan, Sengmanivong, David, Le Pavec, Salamero, Zahraoui: MICAL-like1 mediates epidermal growth factor receptor endocytosis. in Molecular biology of the cell 2011
Rab13 activated the downstream AMPK (zeige PRKAA1 Antikörper) and blocked mTOR (zeige FRAP1 Antikörper) signaling by its functional interaction with Grb2 (zeige GRB2 Antikörper) to regulate autophagy in human vascular endothelial cells.
Inactive Rab13 appears to associate with vesicles via protein-protein interactions. Only following activation does Rab13 associate with the plasma membrane, presumably with insertion of the C-terminal prenyl group into the membrane.
the role of Rab13 as a potent driver of cancer progression.
Rab8A (zeige RAB8A Antikörper) GTPase (zeige RACGAP1 Antikörper) Ser (zeige SIGLEC1 Antikörper)(111) phosphorylation is not directly regulated by PINK1 (zeige PINK1 Antikörper) in vitro and demonstrate in cells the time course of Ser (zeige SIGLEC1 Antikörper)(111) phosphorylation of Rab8A (zeige RAB8A Antikörper), 8B and 13 is markedly delayed compared to phosphorylation of Parkin (zeige PARK2 Antikörper) at Ser (zeige SIGLEC1 Antikörper)(65).
Disruption of Rab13-mediated trafficking dramatically limits the invasive behavior of epithelial cells in vitro and the growth and migration of highly invasive cancer cells in vivo.
It is suggested that Rab13 is associated with a putative secretory function in osteoclasts.
Rab13,VASP (zeige VASP Antikörper),and ZO-1 (zeige TJP1 Antikörper) were found in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn's disease. In patients with ulcerative colitis,these tight junction proteins were not dislocated.
Rab13 specifically mediates the continuous endocytic recycling of occludin (zeige OCLN Antikörper) to the cell surface in both fibroblastic and epithelial cells
Rab13 regulates membrane trafficking between the trans-Golgi network (TGN (zeige TG Antikörper)) and recycling endosomes (RE).
Rab13 acts with Mst1 (zeige MST1 Antikörper) to regulate the spatial distribution of LFA-1 (zeige ITGAL Antikörper) and the motility and trafficking of lymphocytes
Rab13 associates with Grb2 (zeige GRB2 Antikörper), targeting Syx (zeige PLEKHG5 Antikörper) and RhoA (zeige RHOA Antikörper) to Tyr (zeige TYR Antikörper)(1175)-phosphorylated VEGFR2 (zeige KDR Antikörper) at the leading edge.
Rab13 and Rab8A (zeige RAB8A Antikörper) are Rab (zeige HRB Antikörper)-GTPases activated by insulin (zeige INS Antikörper) and downstream of AS160 (zeige TBC1D4 Antikörper) they regulate traffic of GLUT4 (zeige SLC2A4 Antikörper) vesicles.
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.
ras-related protein Rab-13
, RAB13, member RAS oncogene family
, RAS-associated protein RAB13
, cell growth-inhibiting gene 4 protein
, growth-inhibiting gene 4 protein