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Using loss-of-function and gain-of-function approaches, we show that PTPRO promotes the formation of excitatory synapses
PTPROt thus functions as an obligate haploinsufficient TS in CLL, where its expression levels determine its role as a promoter or inhibitor of the tumorigenic process in mice. Partial loss of PTPROt generates the strongest disease phenotype, suggesting that its intermediate expression levels in CLL are selected for.
TLR4 (zeige TLR4 Proteine) and NF-kappaB (zeige NFKB1 Proteine)/p65 (zeige NFkBP65 Proteine) phosphorylation was significantly enhanced in PTPRO over-expressing cells, while significantly down-regulated in PTPRO knockout cells. PTPRO plays ital roles in atherosclerosis (AS) via promoting ox-LDL induced oxidative stress and cell apoptosis through TLR4 (zeige TLR4 Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathway.
PTPRO plays an important role in FH by interacting with TLR4 (zeige TLR4 Proteine).
Study show that EphA4 (zeige EPHA4 Proteine) is a substrate for PTP-oc in osteoclasts and that the molecular mechanism contributing to the PTP-oc-induced up-regulation of the osteoclast activity in part involves its dephosphorylation and inactivation of the EphA4 (zeige EPHA4 Proteine) signaling.
PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment.
The loss of PTPRO in the tumor niche was correlated with larger tumor volume, more metastases, increased number of circulating tumor cells, less apoptosis and reduced necrosis rates in the orthotopic mouse model of breast cancer.
PTPRO regulates insulin (zeige INS Proteine) and lipid metabolism via the PI3K/Akt (zeige AKT1 Proteine)/MDM4 (zeige MDM4 Proteine)/MDM2 (zeige MDM2 Proteine)/P53 (zeige TP53 Proteine) axis by affecting autophagy.
Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-kappaB ac (zeige CTNNB1 Proteine)tivation.
PTPRO deficiency resulted in reduction of NF-kappaB activation in both hepatocytes and macrophages and was correlated to c-Src phosphorylation.
Results provide evidence that PTPRO inhibits ERBB2 (zeige ERBB2 Proteine)-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 (zeige ERBB2 Proteine) signaling suppression and endosomal internalization of ERBB2 (zeige ERBB2 Proteine).
PTPRO is a novel candidate gene in emphysema with severe airflow obstruction.
These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF (zeige PDGFA Proteine) signaling in HSC (zeige FUT1 Proteine) activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases.
The optimal pH value of PTP-oc is approximately 7.0.
Loss of PTPRO expression is associated with chronic lymphocytic leukemia.
Results highlight the PTPRO contribution in negative regulation of SRC (zeige SRC Proteine)/EGFR (zeige EGFR Proteine) signaling in colon cancer.
PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin (zeige CTNNB1 Proteine) accumulation but reduced IFN-gamma (zeige IFNG Proteine) secretion.
Our study suggests an interesting PTPRO/TLR4 (zeige TLR4 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression
PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury.
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
glomerular epithelial protein 1
, osteoclastic phosphotyrosyl phosphatase
, Glomerular epithelial protein 1
, receptor-type protein tyrosine phosphatase D30
, receptor-type tyrosine-protein phosphatase O
, PTPase U2
, protein tyrosine phosphatase U2
, protein tyrosine phosphatase, non-receptor type 15
, receptor protein tyrosine phosphatase RO
, PTP phi
, osteoclastic transmembrane protein-tyrosine phosphatase
, phosphotyrosine phosphatase U2
, protein tyrosine phosphatase PTP-U2