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Human Occludin Protein expressed in Wheat germ - ABIN1313322
Grozdanovic, Čavić, Nešić, Andjelković, Akbari, Smit, Gavrović-Jankulović: Kiwifruit cysteine protease actinidin compromises the intestinal barrier by disrupting tight junctions. in Biochimica et biophysica acta 2016
Viral infectivity was significantly reduced by miR (zeige MLXIP Proteine)-200c but enhanced by miR (zeige MLXIP Proteine)-122.
The mechanism of transition from nondifferentiated to differentiated states in HepaRG cells was studed by proteomics. Two key factors (MMP-14 (zeige MMP14 Proteine) and OCLN) were validated by qRT-PCR and Western blot.
Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin proteolysis and claudin-3 (zeige CLDN3 Proteine) transcription.
Data suggest that long noncoding RNA PlncRNA1 and microRNA miR (zeige MLXIP Proteine)-34c bound together to regulate the expressions of MAZ (zeige MAZ Proteine), ZO-1 (zeige TJP1 Proteine) and occludin.
Study provides evidence that occludin contributes to the regulation of size-reductive proliferation and epithelial cell maturation in a phosphorylation-dependent manner.
Report shows that silencing MARCH3 (zeige MARCH3 Proteine) protects the endothelial barrier and upregulates OCLN in MARCH3 (zeige MARCH3 Proteine)-depleted cells. MARCH3 (zeige MARCH3 Proteine) silencing results in the strengthening of cell-cell contacts and inactivates FoxO1 (zeige FOXO1 Proteine).
STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells.
Downregulation of OCLN is associated with clear cell renal cell carcinoma (zeige MOK Proteine).
These data suggest that the Rho/ROCK signaling pathway is involved in HIV-1 Tat (zeige TAT Proteine)-mediated changes in occludin, RAGE (zeige AGER Proteine), and LRP1 (zeige LRP1 Proteine) in human cerebral microvascular endothelial cells cells.
OCLN is essential for HCV infection of human hepatic cells.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (zeige ROS1 Proteine) generation, cell permeability, levels of ICAM-1 (zeige ICAM1 Proteine), and the tight-junction protein occludin
the presence of occludin at the membrane is dependent in part on calcium-sensitive signaling cascades
cyclic strain modulates both the expression and phosphorylation state of occludin and ZO-1 (zeige TJP1 Proteine) in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
These data demonstrate a novel mechanism of VEGF (zeige VEGFA Proteine)-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability.
The zinc sensing receptor, ZnR/GPR39 (zeige GPR39 Proteine), triggers intracellular Ca(2 (zeige CA2 Proteine)+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 (zeige GPR39 Proteine) is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS (zeige PMP22 Proteine)) ulcerative colitis model.
Occludin expression by epidermal gammadelta T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells.
miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in diabetes mellitus mice.
Tricellulin (zeige MARVELD2 Proteine) is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro.
These findings provide evidence for occludin playing a role in the invasion of Toxoplasma gondii in small intestinal epithelial cells.
occludin deficiency increases susceptibility to ethanol-induced colonic mucosal barrier dysfunction and liver damage in mice.
PHD3 (zeige EGLN3 Proteine) protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 (zeige EGLN3 Proteine) in stabilizing occludin
Zonula occludens-1 (zeige TJP1 Proteine), occludin and E-cadherin (zeige CDH1 Proteine) expression and organization in salivary glands
ZO-1 (zeige TJP1 Proteine) and occludin are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin at the blastocyst stage.
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
, tight-junction protein
, thiopurine methyltransferase
, tight junction protein occludin