anti-NUMB (NUMB) Antikörper

Bezeichnung:
anti-Numb Homolog Antikörper (NUMB)
Auf www.antikoerper-online.de finden Sie aktuell 184 Numb Homolog (NUMB) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NUMB Proteine (11) und NUMB Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 211 NUMB Produkte verfügbar.
Synonyme:
C14orf41, c14_5527, Nb, S171

Meistgesuchte Reaktivitäten zu anti-NUMB (NUMB) Antikörper

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anti-Mouse (Murine) NUMB Antikörper:

anti-Human NUMB Antikörper:

anti-Rat (Rattus) NUMB Antikörper:

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Am meisten referenzierte anti-NUMB Antikörper

  1. Human Polyclonal NUMB Primary Antibody für EIA, IHC (p) - ABIN953787 : Rennstam, McMichael, Berglund, Honeth, Hegardt, Rydén, Luts, Bendahl, Hedenfalk: Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer. in Breast cancer research and treatment 2010 (PubMed)
    Zeige alle 5 Referenzen für 953787

  2. Human Polyclonal NUMB Primary Antibody für ELISA, WB - ABIN184679 : Zhong, Feder, Jiang, Jan, Jan: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. in Neuron 1996 (PubMed)
    Zeige alle 3 Referenzen für 184679

  3. Human Polyclonal NUMB Primary Antibody für IHC (p), WB - ABIN655396 : Kyriazis, Wei, Vandermey, Jo, Xin, Mattson, Chan: Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. in The Journal of biological chemistry 2008 (PubMed)

  4. Chicken Polyclonal NUMB Primary Antibody für ICC, IF - ABIN152992 : Lenihan, Saha, Heimer-McGinn, Cryan, Feng, Young: Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. in Molecular neurobiology 2016 (PubMed)

  5. Human Polyclonal NUMB Primary Antibody für IF (p), IHC (p) - ABIN744428 : Mah, Soloff, Hedrick, Mariani: Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. in Stem cell reports 2015 (PubMed)

Weitere Antikörper gegen NUMB Interaktionspartner

Mouse (Murine) Numb Homolog (NUMB) Interaktionspartner

  1. NUMB is necessary for establishing polarity in coelomic epithelium cells.

  2. investigations revealed that NUMB and NUMBL (zeige NUMBL Antikörper) interacted with small GTPase (zeige RACGAP1 Antikörper) Rab7 (zeige RAB7A Antikörper) to transition ERBB2 (zeige ERBB2 Antikörper) from early to late endosome for degradation.

  3. These findings highlight the importance of Numb and Numbl (zeige NUMBL Antikörper) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis

  4. RBM4 (zeige RBM4 Antikörper) depletion reduced the expression of the proneural gene Mash1 (zeige ASCL1 Antikörper), and such reduction was reversed by an RBM4 (zeige RBM4 Antikörper)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (zeige RBM4 Antikörper) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (zeige RBM4 Antikörper)-depleted neurons were rescued by RBM4 (zeige RBM4 Antikörper)-induced exon 9-lacking Numb isoforms. RBM4 (zeige RBM4 Antikörper) modulates exon selection of Numb.

  5. role in the mediation of TCR degradation

  6. miR (zeige MLXIP Antikörper)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (zeige NOTCH1 Antikörper) to separate stem and non-stem cell fates robustly.

  7. Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (zeige TLR4 Antikörper).

  8. Loss of Numb induces a p53 (zeige TP53 Antikörper)-dependent senescence following skeletal muscle injury.

  9. Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (zeige GRM1 Antikörper).

  10. we observed a glial reaction and an activity-dependent modification of Shh (zeige SHH Antikörper), Noggin (zeige NOG Antikörper), and Numb proteins. we found that Shh (zeige SHH Antikörper) and Noggin (zeige NOG Antikörper) could affect motor performance and that these proteins could be associated with both TDP-43 (zeige TARDBP Antikörper) and Numb

Human Numb Homolog (NUMB) Interaktionspartner

  1. Low NUMB expression is associated with pancreatic cancer.

  2. Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.

  3. investigations revealed that NUMB and NUMBL (zeige NUMBL Antikörper) interacted with small GTPase (zeige RACGAP1 Antikörper) Rab7 (zeige RAB7B Antikörper) to transition ERBB2 (zeige ERBB2 Antikörper) from early to late endosome for degradation.

  4. These findings highlight the importance of Numb and Numbl (zeige NUMBL Antikörper) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis

  5. Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.

  6. Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 (zeige SLC1A1 Antikörper) through binding the YxNxxF (where x stands for any amino acid) motif.

  7. HBeAg and its precursors promote HDM2-mediated degradation and impair transcriptional activity of p53 (zeige TP53 Antikörper) by interacting with NUMB, consequently contributing to hepatocellular carcinoma development.

  8. High expression of Numb is associated with radiation resistance in pancreatic cancer.

  9. Upregulated expression of Numb is associated with reduced radiosensitivity of lung cancer.

  10. Radiation sensitivity of NSCLC stem cells was enhanced with the increase of Numb expression.

NUMB Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NUMB

  • numb gene homolog (Drosophila) (Numb) Antikörper
  • numb homolog (Drosophila) (NUMB) Antikörper
  • numb homolog (Drosophila) (Numb) Antikörper
  • C14orf41 Antikörper
  • c14_5527 Antikörper
  • Nb Antikörper
  • S171 Antikörper

Bezeichner auf Proteinebene für anti-Numb Homolog (NUMB) Antikörper

protein numb homolog , h-Numb , numb gene homolog

GENE ID SPEZIES
18222 Mus musculus
480381 Canis lupus familiaris
395639 Gallus gallus
8650 Homo sapiens
29419 Rattus norvegicus
512187 Bos taurus
100522019 Sus scrofa
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