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These data highlight the importance of the carboxy-terminal motif of the E6 protein and downregulation of PAR3 in tumorigenic transformation of human cervical keratinocytes.
Results suggest that Par3 expression is likely involved in ovarian cancer progression, especially in peritoneal metastasis, probably through modulating IL-6 (zeige IL6 Proteine) /STAT3 (zeige STAT3 Proteine) signaling.
reduced keratinocytes Par3 function fosters a permissive P-cadherin-dependent niche for melanocytes transformation, invasion, and metastasis.
These results demonstrate the importance of Par3 and SNAIL (zeige SNAI1 Proteine) in development of KSHV-induced B-cells cancers
PAR-3 protein expression is frequently lost in primary esophageal squamous cell carcinoma and loss of the PAR-3 protein is associated with aggressive clinicopathological features.
Taken together, these results suggest that the Par3 regulates invasion and metastasis in pancreatic cancers by controlling tight junction assembly via Tiam1 (zeige TIAM1 Proteine).
PAR3 is essential in thrombin (zeige F2 Proteine) stimulated insulin (zeige INS Proteine) secretion.
Knockdown of the polarity protein Par3 reversed the effects of Galpha13 (zeige GNA13 Proteine) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (zeige NOS3 Proteine)-Thr (zeige TRH Proteine)-495 with minimal phosphorylation of eNOS (zeige NOS3 Proteine)-Ser (zeige SIGLEC1 Proteine)-1177 with no change in nitric oxide production.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (zeige IQGAP2 Proteine)) and F2rl2
Simultaneous depletion of PAR-1 (zeige MARK2 Proteine) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (zeige KLK1 Proteine) -signaling axis in neurons that is mediated by PAR1 (zeige F2R Proteine) and PAR2 (zeige F2RL1 Proteine) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (zeige F3 Proteine)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (zeige F2R Proteine)-type thrombin (zeige F2 Proteine) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (zeige F2RL3 Proteine) by the active site of thrombin (zeige F2 Proteine).
This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins\; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
proteinase-activated receptor 3
, Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, CTCL tumor antigen se2-5
, atypical PKC isotype-specific interacting protein
, atypical PKC isotype-specific-interacting protein
, par-3 family cell polarity regulator alpha
, par-3 partitioning defective 3 homolog
, partitioning defective 3 homolog
, partitioning-defective 3 protein
, partitioning-defective protein 3 homolog