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Bile duct adenocarcinoma cells overexpress claudin-18 via the EGFR (zeige EGFR ELISA Kits)/RAS/ERK (zeige EPHB2 ELISA Kits) pathway, contributing to cell proliferation and invasion.
The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 (zeige IL13 ELISA Kits) downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness
suggest that the reduction of CLDN5 (zeige CLDN5 ELISA Kits), 7, and 18 expression loses the suppressive ability of interaction between PDK1 (zeige PDK1 ELISA Kits) and Akt (zeige AKT1 ELISA Kits) and causes sustained phosphorylation of Akt (zeige AKT1 ELISA Kits), resulting in the disordered proliferation in lung squamous carcinoma cells
Data suggest that claudin-18 suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of pyruvate dehydrogenase kinase isoform 1 (PDK1 (zeige PDK1 ELISA Kits)) and proto-oncogene (zeige RAB1A ELISA Kits) protein c (zeige PROC ELISA Kits)-akt (Akt (zeige AKT1 ELISA Kits)).
Human fetal lungs at 23-24 weeks gestational age, the highest-risk period for developing bronchopulmonary dysplasia, a disease of impaired alveolarization, had significantly lower CLDN18 expression relative to postnatal lungs.
Evaluated expression of claudins in gastric cancer and determined their significance for patient outcome. Claudin-3 (zeige CLDN3 ELISA Kits) and claudin-7 (zeige CLDN7 ELISA Kits) were expressed in 25.4% and 29.9% of gastric cancer tissues; 51.5% of gastric cancer tissues had reduced claudin-18.
High levels of CLDN18 are associated with non-small-cell lung cancer.
Downregulation of miR (zeige MLXIP ELISA Kits)-1303 can inhibit proliferation, migration and invasion of gastric cancer cells by targeting CLDN18.
Claudin-18 positivity is a specific phenotype that is characteristic of intestinal-type Mucinous borderline tumours of the ovary
Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer.
The claudin-18 knockout mice exhibited decreased P2X7 (zeige P2RX7 ELISA Kits) mRNA transcript abundance as measured by mRNA expression microarray
CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice.
Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties.
we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling
Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.
Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation
Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis.
Increased expression of claudin-18 is associated with ulcerative colitis.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
, surfactant associated 5
, surfactant associated protein J
, surfactant, pulmonary associated protein J
, claudin 18-like