APP (APP) ELISA Kits

Bezeichnung:
Amyloid beta (A4) Precursor Protein ELISA Kits (APP)
Auf www.antikoerper-online.de finden Sie aktuell 107 Amyloid beta (A4) Precursor Protein (APP) ELISA Kits von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APP Antikörper (918) und APP Proteine (46) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1106 APP Produkte verfügbar.
Synonyme:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

Am meisten referenzierte APP ELISA Kits

  1. Human APP ELISA Kit für Sandwich ELISA - ABIN414520 : Shi, Wu, Xu, Zou: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. in Neurochemistry international 2011 (PubMed)
    Zeige alle 2 Referenzen für 414520

  2. Rat (Rattus) APP ELISA Kit für Sandwich ELISA - ABIN810848 : Tian, Guo, Yue, Lv, Ye, Wang, Chen, Wu, Xu, Liu: Intranasal administration of nerve growth factor ameliorate ?-amyloid deposition after traumatic brain injury in rats. in Brain research 2012 (PubMed)

Weitere ELISA Kits für APP Interaktionspartner

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (zeige GRIN2A ELISA Kits) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (zeige WNT4 ELISA Kits)-PCP (zeige PRCP ELISA Kits) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (zeige MAPK1 ELISA Kits) pathway through a mechanism mediated by PntP2 (zeige ETS2 ELISA Kits).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (zeige IAPP ELISA Kits) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (zeige ABCA2 ELISA Kits)) reduces amyloid-beta production by altering Nicastrin (zeige NCSTN ELISA Kits) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (zeige MAPK8 ELISA Kits) signaling in neurons and induction of JNK (zeige MAPK8 ELISA Kits) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1 (zeige PSEN1 ELISA Kits), and Presenilin 2 (zeige PSEN2 ELISA Kits) as a cause of autosomal dominant AD

  2. The authors now show that the very little Abeta generated by PS1 (zeige PSEN1 ELISA Kits) L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  3. Complicated function of dopamine in Abeta-related neurotoxicity: Dual interactions with Tyr (zeige TYR ELISA Kits)(10) and SNK (zeige ATP1A4 ELISA Kits)(26-28) of Abeta

  4. These studies support the hypothesis that the ratio of Abeta monomers to Abeta oligomers is a critical factor that regulates synapse damage.

  5. UBQLN4, APP, CTNNB1 (zeige CTNNB1 ELISA Kits), SHBG (zeige SHBG ELISA Kits), and COL1A1 (zeige COL1A1 ELISA Kits) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition

  6. Fe65 (zeige APBB1 ELISA Kits) is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 (zeige APBB1 ELISA Kits) constructs expressed in human neuroblastoma (zeige ARHGEF16 ELISA Kits) cells. Our results indicate that PTB2 (zeige PTBP1 ELISA Kits) rather than the WW domain (zeige DRP2 ELISA Kits) is important for the nuclear localization of Fe65 (zeige APBB1 ELISA Kits).

  7. bis (zeige BAG3 ELISA Kits)(sulfosuccinimidyl) suberate (BS3) was used to cross-link Abeta1-42 oligomers prior to electrophoresis. When compared to a previously reported Abeta cross-linking agent, glutaraldehyde, it was quite apparent that BS3 is more suitable for detecting intra-membrane Abeta oligomers and extra-membrane Abeta oligomers states.

  8. This is the first report to show decreased Amyloid beta levels in plasma in Amyloid beta Precursor Protein A673T carriers and thus provides evidence that lower Abeta levels throughout life may be protective against Alzheimer Disease.

  9. APP + PS1 (zeige PSEN1 ELISA Kits) double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP + PS1 (zeige PSEN1 ELISA Kits) rats showed brain pathology as well as reduced memory retention compared to the APP and the ...

  10. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta). Because Abeta and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (zeige CD36 ELISA Kits)- and CD47 (zeige CD47 ELISA Kits)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (zeige APOE ELISA Kits) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. APP and its metabolites are capable of influencing the basic physiology of the pancreas.

  2. treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4

  3. These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 ELISA Kits) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 (zeige LRP1 ELISA Kits) in vivo.

  4. increased APP and/or beta-CTF (zeige NFIA ELISA Kits) impact the endocytic pathway to disrupt NGF (zeige NGFB ELISA Kits) trafficking and signaling, resulting in trophic deficits in basal forebrain cholinergic neurons.

  5. ABETA 25-35 downregulated miR (zeige MLXIP ELISA Kits)-137 and upregulated TNFAIP1 (zeige TNFAIP1 ELISA Kits) in cortical neurons and N2a cells.

  6. These results indicate that platelet APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrophil function.

  7. These findings highlight for the first time that APP-dependent glial cell line-derived neurotropic factor expression drives the process of neuromuscular junction formation, providing new insights into the link between APP gene regulatory network and physiologic functions.

  8. TREM2 (zeige TREM2 ELISA Kits) protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage.

  9. To conclude, our data corroborate a major role of APP for structural plasticity and adaptive remodeling of cortical synapses in the adult brain. They also indicate that lack of APP holoprotein leads to impaired D-serine homeostasis, which is associated with dysfunctional synaptic plasticity.

  10. Pretreatment with a P-glycoprotein inhibitor, which blocks blood-brain barrier transport of Abeta, resulted in significant prolongation of Abeta40 half-life, but only in the latter phase of Abeta clearance from the interstitial fluid.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (zeige S100A8 ELISA Kits)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. Amyloid beta precursor protein and prion protein (zeige PRNP ELISA Kits) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (zeige MKRN1 ELISA Kits) and Aplp2 (zeige APLP2 ELISA Kits) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (zeige PSEN1 ELISA Kits)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) Interaktionspartner

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (zeige SUCLA2 ELISA Kits) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (zeige IGF1 ELISA Kits) signaling

APP Antigen-Profil

Beschreibung des Gens

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) Elisa Kit
  • amyloid beta (A4) precursor protein (APP) Elisa Kit
  • amyloid beta (A4) precursor protein (app) Elisa Kit
  • amyloid beta (A4) precursor protein (App) Elisa Kit
  • amyloid beta (A4) precursor protein a (appa) Elisa Kit
  • beta amyloid protein precursor (LOC100009546) Elisa Kit
  • AAA Elisa Kit
  • ABETA Elisa Kit
  • Abpp Elisa Kit
  • AD1 Elisa Kit
  • Adap Elisa Kit
  • Ag Elisa Kit
  • app Elisa Kit
  • APP-like Elisa Kit
  • APPI Elisa Kit
  • appl Elisa Kit
  • BcDNA:GH04413 Elisa Kit
  • betaApp Elisa Kit
  • CG7727 Elisa Kit
  • CTFgamma Elisa Kit
  • Cvap Elisa Kit
  • Dmel\\CG7727 Elisa Kit
  • E030013M08Rik Elisa Kit
  • EG:65F1.5 Elisa Kit
  • PN-II Elisa Kit
  • PN2 Elisa Kit
  • wu:fj34d10 Elisa Kit
  • wu:fk65e12 Elisa Kit
  • zgc:85740 Elisa Kit

Bezeichner auf Proteinebene für APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPEZIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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