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AP-2beta up-regulates the transcription of the CRYAB (zeige CRYAB ELISA Kits) gene through stabilizing p53 (zeige TUBB ELISA Kits).
CVAK104 (zeige SCYL2 ELISA Kits) binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin (zeige AP2B1 ELISA Kits) subunit of AP2 (zeige TFAP2A ELISA Kits)
tfap2b and its close relative, tfap2a (zeige TFAP2A ELISA Kits), play redundant roles in the ectoderm to control skeletogenesis of neural crest cells
Study systematically examined the expression profile of AP-2 (zeige TFAP2A ELISA Kits) family in the developing mouse and chick spinal cord and found that AP-2alpha (zeige TFAP2A ELISA Kits) and AP-2beta are specifically expressed in post-mitotic dorsal interneurons. Subsequent functional assessment in chick embryos demonstrated that AP-2alpha (zeige TFAP2A ELISA Kits) and AP-2beta have distinct functions in dorsal interneuron specification and differentiation.
AP-2 beta and beta-catenin (zeige CTNNB1 ELISA Kits) interact both in vitro through GST pull-down assays and in vivo by co-immunoprecipitation. We further identified the interaction regions to the DNA-binding domain of AP-2 beta and the 1-9 Armadillo (zeige PKP1 ELISA Kits) repeats of beta-catenin (zeige CTNNB1 ELISA Kits).
the Tfap2a (zeige TFAP2A ELISA Kits) and Tfap2b transcription factors were identified as two major downstream effectors of Ptf1a (zeige PTF1A ELISA Kits).
critical roles for AP-2 (zeige TFAP2A ELISA Kits) activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a (zeige TFAP2A ELISA Kits), Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a (zeige TFAP2A ELISA Kits) and Tcfap2b in horizontal and amacrine cell development
Tfap2b is associated with the development and remodeling of mouse ductus arteriosus and limb patterning.
PKD (zeige PRKD1 PLURAL_@2013@) is thus a common modulator of the DNA binding activity of AP-2alpha (zeige TFAP2A PLURAL_@2013@) and AP-2beta through their phosphorylation for negative regulation of the ABCA1 (zeige ABCA1 PLURAL_@2013@) and adiponectin (zeige ADIPOQ PLURAL_@2013@) genes expression, respectively.
postprandial activation of PKCmicro plays a role in disordered postprandial adipocytokine expression through AP-2beta.
Whereas AP-2alpha (zeige TFAP2A ELISA Kits)/beta transcription factors are in vivo not required for the onset or maintenance of noradrenergic differentiation, their essential survival functions are demonstrated for sympathetic progenitors and noradrenergic neurons.
Data suggest that AP-2beta plays critical roles in the epinephrine phenotype and maturation of adrenal chromaffin cells.
Tfap2beta, Et-1 (zeige EDN1 ELISA Kits), and Hif2alpha (zeige EPAS1 ELISA Kits) act in a transcriptional network during ductal smooth muscle development. Disruption of this pathway may contribute to patent ductus arteriosus by affecting development of smooth muscle in the ductus arteriosus.
Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (zeige AGTR1 ELISA Kits)), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor (zeige TNF ELISA Kits) receptor-associated factor 1 (TRAF1 (zeige TRAF1 ELISA Kits)) have been reported to be associated with the incidence of PDA in preterm infants.
results suggest that TFAP2B is playing a vital role in retaining retinoic acid responsiveness and mediating noradrenergic neuronal differentiation in neuroblastoma (zeige ARHGEF16 ELISA Kits).
TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK (zeige EPHB2 ELISA Kits) and VEGF (zeige VEGFA ELISA Kits)/PEDF (zeige SERPINF1 ELISA Kits) signaling.
The AP-2beta polymorphism significantly influenced cognitive performance, whereas the MAOA (zeige MAOA ELISA Kits) and COMT (zeige COMT ELISA Kits) polymorphisms did not.
A haploinsufficiency effect of TFAP2B could be involved in familial isolated patent ductus arteriosus.
TFAP2B rs987237 and dietary protein/carbohydrate interacted to modify weight maintenance.
genomic GATA4 (zeige GATA4 ELISA Kits) and TFAP2B missense mutations may be associated with nonfamilial congenital heart disease with diverse clinical phenotypes in patients with congenital heart disease from southern China
Under energy restriction, TFAP2B may modify the effect of dietary fat intake on weight loss and waist reduction
The findings suggest the lack of involvement of known mutations of TFAP2B with syndromic or nonsyndromic CHDs in Mysore patients
Expression of TFAP2beta and TFAP2gamma (zeige TFAP2C ELISA Kits) genes in Xenopus laevis.
LH and insulin (zeige INS ELISA Kits) stimulate transcription of -976/+31 bp 5 (zeige HSPD1 ELISA Kits)'-upstream cis (zeige CISH ELISA Kits)-acting region of porcine CYP17 (zeige CYP17A1 ELISA Kits) gene. Maximal transcriptional responsiveness requires proximal Sp1 (zeige SP1 ELISA Kits) and AP-2-like sequences -193 to -180 bp 5 (zeige HSPD1 ELISA Kits)' upstream of transcriptional start site.
Data demonstrates the colocalization of MARK with AP-2 and clathrin, as well as other MARK-interacting proteins such as PAK5.
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
, activating enhancer-binding protein 2 beta
, activating enhancer-binding protein 2-beta
, transcription factor AP-2-beta
, activating enhancer binding protein 2 beta
, transcription factor AP-2 beta
, AP2 transcription factor
, beta adaptin
, beta adaptin drosophila 1