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Cow (Bovine) Polyclonal NOX4 Primary Antibody für ICC, IHC (fro) - ABIN189715
Maranchie, Zhan: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. in Cancer research 2005
Show all 48 Pubmed References
Human Polyclonal NOX4 Primary Antibody für FACS, ICC - ABIN4340462
Weyemi, Caillou, Talbot, Ameziane-El-Hassani, Lacroix, Lagent-Chevallier, Al Ghuzlan, Roos, Bidart, Virion, Schlumberger, Dupuy: Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. in Endocrine-related cancer 2010
Show all 34 Pubmed References
Dog (Canine) Polyclonal NOX4 Primary Antibody für IF (p), IHC (p) - ABIN737526
Khan, Byer, Khan: Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase. in Urology 2014
Human Polyclonal NOX4 Primary Antibody für IF (p), IHC (p) - ABIN702610
Kashiwabara, Ambe, Nakagawa, Watanabe: Immunohistochemical localization of Nox in mouse circumvallate papillae. in Tissue & cell 2015
Human Polyclonal NOX4 Primary Antibody für IHC, IHC (p) - ABIN409683
Zhang, Liu, Hu: Inhibiting cancer metastasis via targeting NAPDH oxidase 4. in Biochemical pharmacology 2013
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (zeige ARCN1 Antikörper).
TIS21 (zeige BTG2 Antikörper) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (zeige ROS1 Antikörper)-ABI2 (zeige ABI2 Antikörper)-DRF (zeige MPO Antikörper) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (zeige NOX1 Antikörper)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (zeige TGFB1 Antikörper) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (zeige ROS1 Antikörper) and p38MAPK (zeige MAPK14 Antikörper). ROS (zeige ROS1 Antikörper) derived from NADPH oxidase (zeige NOX1 Antikörper) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (zeige BRD4 Antikörper) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (zeige TGFB1 Antikörper)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (zeige CYBA Antikörper) is possible and that the activity of Nox1 (zeige NOX1 Antikörper) and Nox4 but not Nox5 (zeige NOX5 Antikörper) exclusively depends on p22phox (zeige CYBA Antikörper).
These processes are mediated upstream by the reactive oxygen species (ROS (zeige ROS1 Antikörper))-producing enzyme Nox4.
data suggest that monocytic Nox4 is a central regulator of actin dynamics, and induction of Nox4 is the rate-limiting step in metabolic stress-induced monocyte priming and dysfunction associated with accelerated atherosclerosis and the progression of atherosclerotic plaques
findings demonstrate that manipulation of the host PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway and Nox4 gene expression is a novel mechanism involved in T. gondii survival and proliferation
we used the Ang II (zeige AGT Antikörper) infused hph-1 (zeige EGLN2 Antikörper) mice to examine the roles of NOX isoforms in the development of AAA (zeige AAAS Antikörper). We generated double mutants of hph-1 (zeige EGLN2 Antikörper)-NOX1 (zeige NOX1 Antikörper), hph-1 (zeige EGLN2 Antikörper)-NOX2 (zeige CYBB Antikörper), hph-1 (zeige EGLN2 Antikörper)-p47phox, and hph-1 (zeige EGLN2 Antikörper)-NOX4
The major reactive oxygen species (ROS (zeige ROS1 Antikörper)) source in brain, NADPH oxidase (zeige NOX1 Antikörper) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (zeige NFE2L2 Antikörper), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (zeige ROS1 Antikörper)-MAPK (zeige MAPK1 Antikörper) signalling pathway.
Nox2 (zeige CYBB Antikörper)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.
FYN (zeige FYN Antikörper) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (zeige EDN1 Antikörper) production.
CYLD (zeige CYLD Antikörper) contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling.
Data suggests that ROS (zeige ROS1 Antikörper) produced during primitive endoderm differentiation is dependent in part on increased NOX1 (zeige NOX1 Antikörper) and NOX4 levels, which is under the control of GATA6 (zeige GATA6 Antikörper). Furthermore, these results suggest that the combined activity of multiple NOX proteins is necessary for the differentiation of F9 cells to primitive endoderm.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (zeige TGFB1 Antikörper)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (zeige NOX1 Antikörper) mediates oxidative stress and apoptosis caused by TNF-alpha (zeige TNF Antikörper) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (zeige NOX1 Antikörper)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (zeige HMOX2 Antikörper).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (zeige NOX1 Antikörper) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (zeige P4HB Antikörper) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4