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plastid HXK enzyme activities, location, function in signal transduction, and cross talk to plastid GUN1 protein (a key signaling factor) were investigated. pHXK may be a node of convergence for sugar-mediated and PGE (zeige LIPF ELISA Kits)-derived signals.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
HK3 expression is significantly upregulated in human masticatory mucosa during wound healing
HK1 (zeige KCNA4 ELISA Kits) and HK2 (zeige HK2 ELISA Kits) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples.
Through glycolysis and arachidonic acid metabolism, HK3 and PTGS2 (zeige PTGS2 ELISA Kits) might play important roles in pediatric ALL and its prognosis, and thus, might be potential targets for therapeutic intervention to suppress pediatric ALL.
Altogether, our data provide an explanation for low HK3 and KLF5 (zeige KLF5 ELISA Kits) expression in particular AML (zeige RUNX1 ELISA Kits) subtype and establish these genes as novel CEBPA (zeige CEBPA ELISA Kits) targets during neutrophil differentiation.
HK3 is: (1) directly activated by PU.1, (2) repressed by PML (zeige PML ELISA Kits)-RARA (zeige RARA ELISA Kits), and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia (zeige PML ELISA Kits) cells.
Data demonstrated that in addition to galectin-3 (zeige LGALS3 ELISA Kits), HK III and cyclin A (zeige CCNA2 ELISA Kits) profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Data show that HKIII exerts protective effects against oxidative stress, perhaps by increasing ATP levels, reducing oxidant-induced ROS (zeige ROS1 ELISA Kits) production, preserving mitochondrial membrane potential, and increasing mitochondrial biogenesis.
The expression pattern of HK3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
hexokinase 3 (white cell)
, hexokinase type III
, ATP:D-hexose 6-phosphotransferase
, HK III