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Human AGER Protein expressed in Human Cells - ABIN2004453
Sugaya, Fukagawa, Matsumoto, Mita, Takahashi, Ando, Inoko, Ikemura et al.: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart ... in Genomics 1995
Show all 5 Pubmed References
A capture method based on the VC1 domain reveals new binding properties of the AGER.
These data indicate that RAGE plays a central role in maintaining inflammatory signaling in PDAC that benefits tumor growth.
In conclusion, RAGE is clearly involved in corneal re-epithelialization most probably mediated by signalling via S100 proteins.
RAGE binds to a diverse repertoire of ligands. DIAPH1 (zeige DIAPH1 Proteine) interaction with the RAGE cytoplasmic domain. [review]
High RAGE expression is associated with mesothelioma.
There was no significant difference in plasma levels of sRAGE or HMGB1 (zeige HMGB1 Proteine) between pAPS (zeige PAPSS1 Proteine) patients and HCs (zeige HLCS Proteine). Plasma levels of sRAGE/HMGB1 (zeige HMGB1 Proteine) could not be utilized to differentiate between APA (zeige ENPEP Proteine)+SLE and APS (zeige SH2B2 Proteine)+SLE patients
Ligand-induced association of RAGE homodimers on the cell surface increases the molecular dimension of the receptor, recruiting DIAPH1 (zeige DIAPH1 Proteine) and activating signaling pathways.
AGER polymorphisms showed no statistically significant difference between patients with primary open-angle glaucoma and healthy controls.
Our findings demonstrate how RAGE-PR3 interactions between human prostate cancer cells and the bone marrow microenvironment mediate bone metastasis during prostate cancer progression
The severity of acute respiratory distress syndrome in preterm infants seemed to be associated with the plasma level of sRAGE and AQP5 (zeige AQP5 Proteine): the more severe the disease, the higher the plasma level of sRAGE and AQP5 (zeige AQP5 Proteine)
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (zeige ACAN Proteine) content in nucleus pulposus.
RAGE is phosphorylated by the ATM (zeige ATM Proteine) kinase and is recruited to the site of DNA-double-strand break via an early DNA damage response.
receptor for advanced glycation end products (RAGE) was required for stabilization of beta-catenin (zeige CTNNB1 Proteine) in toluene diisocyanate-induced asthma, identifying protective effects of RAGE blockade in this mouse model
perturbation of Bone marrow mesenchymal stromal cells in diabetes mellitus could be partially explained by chronic RAGE signaling.
RAGE mediates inflammation that contributes to lung damage, in cigarette smoke-induced lung pathology.
Ager deletion enhances ischemic muscle inflammation, angiogenesis, and blood flow recovery in diabetic mice.
HMGB1 (zeige HMGB1 Proteine) neither exerts influence on cardiac remodeling by binding to RAGE nor induces apoptosis of cardiomyocytes under physiological condition
Our results indicate that lack of RAGE has no significant impact on septic arthritis. However, RAGE-/- mice had significantly higher BMD (zeige BEST1 Proteine) compared to WT mice, which coincided with lower IL-17A (zeige IL17A Proteine) in RAGE-/- mice. In sepsis, RAGE deficiency impairs bacterial kidney clearance.
SAA (zeige SAA1 Proteine) is a potential new uremic toxin involved in uremia-related atherosclerosis through interaction with RAGE.
that selective RAGE regulation reflects a self-protective mechanism to maintain low levels of RAGE ligands
Data show that receptor for advanced glycation end products (RAGE) impairs collateral growth in a diabetic setting and also in a non-diabetic setting, indicting the importance of RAGE and alternate RAGE ligands in the setting of collateral vessel growth.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
advanced glycosylation end product-specific receptor
, RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, receptor for advanced glycosylation end products
, advanced glycation end-products receptor
, advanced glycosylation end product-specific receptor variant 2