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Suggest that IL-6 (zeige IL6 Proteine) could promote the invasiveness of breast cancer cells by inducing secretion of TIMP-1 (zeige TIMP1 Proteine) and -2, causing a disturbance in TIMP/MMP balance.
High TIMP2 expression is associated with acute kidney injury.
expression of TIMP2 was inversely associated with miR (zeige MLXIP Proteine)-106a in nodule tissues. Apoptotic body was also seen under electron microscope accompanied by silencing of miR (zeige MLXIP Proteine)-106a. Together, this data indicated that miR (zeige MLXIP Proteine)-106a may act as an oncogene (zeige RAB1A Proteine) and contribute to gastric cancer development.
Data show that the mean values for TIMP1 (zeige TIMP1 Proteine), TIMP2 and MMP2 (zeige MMP2 Proteine) were lower in survivors, MMP9 (zeige MMP9 Proteine) was higher in survivors.
Urine [TIMP-2]*[IGFBP7 (zeige IGFBP7 Proteine)] is a promising candidate for early detection of AKI, especially in ruling-out AKI
We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7 (zeige MMP7 Proteine), MMP-10 (zeige MMP10 Proteine) and TIMP-1 (zeige TIMP1 Proteine) correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. MMP-10 (zeige MMP10 Proteine), MMP-7 (zeige MMP7 Proteine), TIMP-1 (zeige TIMP1 Proteine), TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.
At hospital admission, all viral gastroenteritis (GE) patients viral gastroenteritis (GE) patients demonstrated increased MMP-9 (zeige MMP9 Proteine) and decreased MMP-2 (zeige MMP2 Proteine) and TIMP-2 serum levels; kinetics of serum MMP-2 (zeige MMP2 Proteine), MMP-9 (zeige MMP9 Proteine), and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients; involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the
Meta-analysis indicated that urinary [TIMP-2].[IGFBP7 (zeige IGFBP7 Proteine)] may be a reliable biomarker for the early detection of acute kidney injury in adults.
Results show that resistant hypertension was associated with higher TIMP-2 levels and low MMP-2 (zeige MMP2 Proteine)/TIMP-2 ratio, suggesting that these regulators of ECM (zeige MMRN1 Proteine) remodeling play a key role in blood pressure control in this high-risk subset of hypertensive individuals.
Data indicate the involvement of PKC-alpha (zeige PKCa Proteine) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (zeige NFKB1 Proteine)-MT1-MMP (zeige MMP14 Proteine)-dependent and -independent pathway.
A differential pattern of matrix metalloproteinase-2 (zeige MMP2 Proteine) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (zeige MMP14 Proteine), MMP-2 (zeige MMP2 Proteine) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Results describe distinct changes in expression of MMP2 (zeige MMP2 Proteine), MMP14 (zeige MMP14 Proteine), and the metallopeptidase (zeige ECEL1 Proteine) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.
Production of TIMP-1 (zeige TIMP1 Proteine) was augmented by IL-1alpha, TNFalpha (zeige TNF Proteine), and hepatocyte growth factor (zeige HGF Proteine) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.
the different temporal expression patterns of TIMP-1 (zeige TIMP1 Proteine) and TIMP-2 suggest that TIMP-1 (zeige TIMP1 Proteine) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance
Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle
Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (zeige MMP2 Proteine)) from the MMP-2 (zeige MMP2 Proteine)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (zeige MMP2 Proteine) and the complex itself.
oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (zeige MMP2 Proteine) subsequently inhibits Na+ dependent Ca2 (zeige CA2 Proteine)+ uptake in the microsomes
TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
The pathology of laminitis is associated with increased and lowered transcription of MMP-14 (zeige MMP14 Proteine) and TIMP-2, respectively.
the protein expression levels of TIMP-2 and PBEF (zeige NAMPT Proteine) in cloned placentae, were examined.
demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (zeige TIMP1 Proteine) during the pathogenesis of atherosclerosis
Further investigation of MMP2 (zeige MMP2 Proteine) inhibitors of TIMP2/TIMP4 (zeige TIMP4 Proteine) showed an upregulated TIMP2 expression, but not TIMP4 (zeige TIMP4 Proteine). low-dose pre-radiation attenuates the skin inflammation and ROS (zeige ROS1 Proteine) production induced by medium-dose UV radiation
TIMP2 and TIMP3 (zeige TIMP3 Proteine) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function
Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (zeige MAPK14 Proteine) signaling pathway.
High TIMP2 expression is associated with liver fibrosis.
TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (zeige MMP2 Proteine) activation
Gene expression of Mmp-12 (zeige MMP12 Proteine) and Mmp-13 (zeige MMP13 Proteine), and Timp-1 (zeige TIMP1 Proteine) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (zeige MMP2 Proteine), and Mmp-9 (zeige MMP9 Proteine) expression was modest.
Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (zeige TGFB1 Proteine), PAI-1 (zeige SERPINE1 Proteine) and RAGE (zeige AGER Proteine) in diabetic db/db (zeige LEPR Proteine) cells.
This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.
To further study the function of TIMP-2 in development, we utilized zebrafish as an experimental model system
membrane-type 1 metalloproteinase, gelatinase A (zeige MMP2 Proteine) , and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
, metalloproteinase inhibitor 2
, tissue inhibitor of metalloproteinase 2
, tissue inhibitor of metalloproteinases 2
, collagenase inhibitor
, tissue inhibitor of mettaloproteinase 2
, tissue inhibitor of metalloproteinase-2
, tissue inhibitor of matrix metalloproteinase-2
, metalloproteinase inhibitor TIMP-2