Metalloproteinase Inhibitor 2 Proteine (TIMP2)

Bezeichnung:
Metalloproteinase Inhibitor 2 Proteine (TIMP2)
Auf www.antikoerper-online.de finden Sie aktuell 45 Metalloproteinase Inhibitor 2 (TIMP2) Proteine von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Metalloproteinase Inhibitor 2 Antikörper (326) und Metalloproteinase Inhibitor 2 Kits (105) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 488 Metalloproteinase Inhibitor 2 Produkte verfügbar.
Synonyme:
CSC-21K, D11Bwg1104e, DDC8, etID32613.12, fa96h09, Timp-2, timp2, wu:fa96h09, zgc:136726
alle Proteine anzeigen Gen GeneID UniProt
TIMP2 7077 P16035
TIMP2 29543 P30121
TIMP2 21858  

Weitere Synonyme anzeigen

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Am meisten referenzierte Metalloproteinase Inhibitor 2 Proteine

  1. Human TIMP2 Protein expressed in HEK-293 - ABIN2666719 : Bourboulia, Stetler-Stevenson: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. in Seminars in cancer biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 2666719

  2. Human TIMP2 Protein expressed in Human Cells - ABIN2002771 : Seo, Li, Guedez, Wingfield, Diaz, Salloum, Wei, Stetler-Stevenson: TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. in Cell 2003 (PubMed)
    Zeige alle 3 Referenzen für 2002771

  3. Human TIMP2 Protein expressed in Human Cells - ABIN2002769 : Stetler-Stevenson, Krutzsch, Liotta: TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family. in Matrix (Stuttgart, Germany). Supplement 1993 (PubMed)
    Zeige alle 3 Referenzen für 2002769

  4. Human TIMP2 Protein expressed in HEK-293 Cells - ABIN2181824 : Stetler-Stevenson, Krutzsch, Liotta: Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. in The Journal of biological chemistry 1989 (PubMed)
    Zeige alle 3 Referenzen für 2181824

  5. Human TIMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1098377 : Bahudhanapati, Zhang, Sidhu, Brew: Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1)). in The Journal of biological chemistry 2011 (PubMed)
    Zeige alle 2 Referenzen für 1098377

  6. Human TIMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1047368 : Stetler-Stevenson, Brown, Onisto, Levy, Liotta: Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. in The Journal of biological chemistry 1990 (PubMed)
    Zeige alle 2 Referenzen für 1047368

Weitere Proteine zu Metalloproteinase Inhibitor 2 Interaktionspartnern

Human Metalloproteinase Inhibitor 2 (TIMP2) Interaktionspartner

  1. High TIMP2 expression is associated with acute kidney injury.

  2. High TIMP2 expression is associated with acute kidney injury.

  3. expression of TIMP2 was inversely associated with miR (zeige MLXIP Proteine)-106a in nodule tissues. Apoptotic body was also seen under electron microscope accompanied by silencing of miR (zeige MLXIP Proteine)-106a. Together, this data indicated that miR (zeige MLXIP Proteine)-106a may act as an oncogene (zeige RAB1A Proteine) and contribute to gastric cancer development.

  4. Data show that the mean values for TIMP1 (zeige TIMP1 Proteine), TIMP2 and MMP2 (zeige MMP2 Proteine) were lower in survivors, MMP9 (zeige MMP9 Proteine) was higher in survivors.

  5. Urine [TIMP-2]*[IGFBP7 (zeige IGFBP7 Proteine)] is a promising candidate for early detection of AKI, especially in ruling-out AKI

  6. We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7 (zeige MMP7 Proteine), MMP-10 (zeige MMP10 Proteine) and TIMP-1 (zeige TIMP1 Proteine) correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. MMP-10 (zeige MMP10 Proteine), MMP-7 (zeige MMP7 Proteine), TIMP-1 (zeige TIMP1 Proteine), TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.

  7. At hospital admission, all viral gastroenteritis (GE) patients viral gastroenteritis (GE) patients demonstrated increased MMP-9 (zeige MMP9 Proteine) and decreased MMP-2 (zeige MMP2 Proteine) and TIMP-2 serum levels; kinetics of serum MMP-2 (zeige MMP2 Proteine), MMP-9 (zeige MMP9 Proteine), and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients; involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the

  8. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7 (zeige IGFBP7 Proteine)] may be a reliable biomarker for the early detection of acute kidney injury in adults.

  9. Results show that resistant hypertension was associated with higher TIMP-2 levels and low MMP-2 (zeige MMP2 Proteine)/TIMP-2 ratio, suggesting that these regulators of ECM (zeige MMRN1 Proteine) remodeling play a key role in blood pressure control in this high-risk subset of hypertensive individuals.

  10. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 (zeige IGFBP7 Proteine) is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 (zeige IGFBP7 Proteine) was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules.

Cow (Bovine) Metalloproteinase Inhibitor 2 (TIMP2) Interaktionspartner

  1. Data indicate the involvement of PKC-alpha (zeige PKCa Proteine) in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB (zeige NFKB1 Proteine)-MT1-MMP (zeige MMP14 Proteine)-dependent and -independent pathway.

  2. A differential pattern of matrix metalloproteinase-2 (zeige MMP2 Proteine) and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.

  3. MMP-14 (zeige MMP14 Proteine), MMP-2 (zeige MMP2 Proteine) and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  4. Results describe distinct changes in expression of MMP2 (zeige MMP2 Proteine), MMP14 (zeige MMP14 Proteine), and the metallopeptidase (zeige ECEL1 Proteine) inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.

  5. Production of TIMP-1 (zeige TIMP1 Proteine) was augmented by IL-1alpha, TNFalpha (zeige TNF Proteine), and hepatocyte growth factor (zeige HGF Proteine) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments.

  6. the different temporal expression patterns of TIMP-1 (zeige TIMP1 Proteine) and TIMP-2 suggest that TIMP-1 (zeige TIMP1 Proteine) may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance

  7. Identification, purification and partial characterization of timp-2 in bovine pulmonary artery smooth muscle

  8. Results describe the isolation of matrix metalloproteinase 2 (MMP-2 (zeige MMP2 Proteine)) from the MMP-2 (zeige MMP2 Proteine)/tissue inhibitor of metalloproteinase 2 (TIMP-2) complex, and the characterization of both isolated MMP-2 (zeige MMP2 Proteine) and the complex itself.

  9. oxidants inactivate TIMP-2, and the resulting activation of MMP-2 (zeige MMP2 Proteine) subsequently inhibits Na+ dependent Ca2 (zeige CA2 Proteine)+ uptake in the microsomes

  10. TIMP-2 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

Horse (Equine) Metalloproteinase Inhibitor 2 (TIMP2) Interaktionspartner

  1. The pathology of laminitis is associated with increased and lowered transcription of MMP-14 (zeige MMP14 Proteine) and TIMP-2, respectively.

Mouse (Murine) Metalloproteinase Inhibitor 2 (TIMP2) Interaktionspartner

  1. the protein expression levels of TIMP-2 and PBEF (zeige NAMPT Proteine) in cloned placentae, were examined.

  2. demonstrate that TIMP-2 plays a greater protective role than TIMP-1 (zeige TIMP1 Proteine) during the pathogenesis of atherosclerosis

  3. Further investigation of MMP2 (zeige MMP2 Proteine) inhibitors of TIMP2/TIMP4 (zeige TIMP4 Proteine) showed an upregulated TIMP2 expression, but not TIMP4 (zeige TIMP4 Proteine). low-dose pre-radiation attenuates the skin inflammation and ROS (zeige ROS1 Proteine) production induced by medium-dose UV radiation

  4. TIMP2 and TIMP3 (zeige TIMP3 Proteine) play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  5. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (zeige MAPK14 Proteine) signaling pathway.

  6. High TIMP2 expression is associated with liver fibrosis.

  7. TIMP2 promotes kidney injury through metalloproteinase (MMP)2 (zeige MMP2 Proteine) activation

  8. Gene expression of Mmp-12 (zeige MMP12 Proteine) and Mmp-13 (zeige MMP13 Proteine), and Timp-1 (zeige TIMP1 Proteine) was strongly upregulated at all time points in RD compared with controls. Timp-2, Mmp-2 (zeige MMP2 Proteine), and Mmp-9 (zeige MMP9 Proteine) expression was modest.

  9. Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta (zeige TGFB1 Proteine), PAI-1 (zeige SERPINE1 Proteine) and RAGE (zeige AGER Proteine) in diabetic db/db (zeige LEPR Proteine) cells.

  10. This study suggests that miR-17 participates in the regulation of cardiac matrix remodeling and provides a novel therapeutic approach using miR-17 inhibitors to prevent remodeling and heart failure after MI.

Zebrafish Metalloproteinase Inhibitor 2 (TIMP2) Interaktionspartner

  1. To further study the function of TIMP-2 in development, we utilized zebrafish as an experimental model system

  2. membrane-type 1 metalloproteinase, gelatinase A (zeige MMP2 Proteine) , and tissue inhibitor 2 of metalloproteinases mRNA transcripts were expressed in the blastema

Metalloproteinase Inhibitor 2 (TIMP2) Protein Überblick

Protein Überblick

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Alternative names and synonyms associated with Metalloproteinase Inhibitor 2 (TIMP2)

  • TIMP metallopeptidase inhibitor 2 (TIMP2)
  • TIMP metallopeptidase inhibitor 2 (Timp2)
  • tissue inhibitor of metalloproteinase 2 (Timp2)
  • tissue inhibitor of metalloproteinase 2a (timp2a)
  • CSC-21K Protein
  • D11Bwg1104e Protein
  • DDC8 Protein
  • etID32613.12 Protein
  • fa96h09 Protein
  • Timp-2 Protein
  • timp2 Protein
  • wu:fa96h09 Protein
  • zgc:136726 Protein

Bezeichner auf Proteinebene für TIMP2

TIMP-2 , metalloproteinase inhibitor 2 , tissue inhibitor of metalloproteinase 2 , tissue inhibitor of metalloproteinases 2 , collagenase inhibitor , tissue inhibitor of mettaloproteinase 2 , tissue inhibitor of metalloproteinase-2 , tissue inhibitor of matrix metalloproteinase-2 , metalloproteinase inhibitor TIMP-2

GENE ID SPEZIES
7077 Homo sapiens
29543 Rattus norvegicus
282093 Bos taurus
100008689 Oryctolagus cuniculus
374178 Gallus gallus
396988 Sus scrofa
100034134 Equus caballus
403633 Canis lupus familiaris
743167 Pan troglodytes
100217406 Ovis aries
21858 Mus musculus
100135629 Cavia porcellus
359835 Danio rerio
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