Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteine (RAPGEF3)

Bezeichnung:
Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteine (RAPGEF3)
Auf www.antikoerper-online.de finden Sie aktuell 8 Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Rap Guanine Nucleotide Exchange Factor (GEF) 3 Antikörper (66) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 86 Rap Guanine Nucleotide Exchange Factor (GEF) 3 Produkte verfügbar.
Synonyme:
2310016P22Rik, 9330170P05Rik, bcm910, CAMP-GEFI, Epac, Epac1, HSU79275, RAPGEF3, si:dkey-27m20.2
alle Proteine anzeigen Gen GeneID UniProt
RAPGEF3 10411 O95398
RAPGEF3 223864 Q8VCC8
RAPGEF3 59326 Q9Z1C8

Weitere Synonyme anzeigen

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Weitere Proteine zu Rap Guanine Nucleotide Exchange Factor (GEF) 3 Interaktionspartnern

Cow (Bovine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Interaktionspartner

  1. prostacyclin regulates bone growth via the Epac/Rap1 pathway

Xenopus laevis Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Interaktionspartner

  1. cAMP binds Xepac protein enabling it to activate the Ca2+ pathway, which is necessary to start and maintain X. laevis vitellogenin uptake.

Human Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Interaktionspartner

  1. This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 (zeige RAPGEF4 Proteine) play important roles in the structure and function of the heart under physiological and pathological conditions. [review]

  2. This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1 (zeige SLC9A3R1 Proteine). Our findings identify a new CFTR (zeige CFTR Proteine)-interacting protein and demonstrate that cAMP activates CFTR (zeige CFTR Proteine) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.

  3. The contribution of EGFR (zeige EGFR Proteine), EPAC, and Ca(2 (zeige CA2 Proteine)+) in CDCA-induced activation of CFTR (zeige CFTR Proteine)-dependent Cl(-) secretion.

  4. Microtubule stabilization was further suggested by the finding that ascorbate increased the amount of Epac1 bound to alpha-tubulin (zeige TUBA4A Proteine).

  5. during Epac1-induced activation of mTORC1 and mTORC2 (zeige CRTC2 Proteine), Epac1 may have an additional function as a scaffold protein (zeige HOMER1 Proteine)

  6. The overexpression of EPAC1 can be used as a marker to predict the outcome of patients with GC, and EPAC1 represents a potential therapeutic modality for treating gastric cancer

  7. our data provide new insight into the essential role of Epac1 in regulating growth of ovarian cancer cells and suggest that Epac1 might represent an attractive therapeutic target for treatment of ovarian cancer.

  8. These findings suggested Epac is connected to the SDF-1 (zeige CXCL12 Proteine) signaling cascades. In conclusion, our study revealed that Epac plays a role in human mesenchymal stem cells (hMSCs)homing by promoting adhesion and migration. Appropriate manipulation of Epac may enhance the homing of hMSCs and facilitate their future clinical applications.

  9. EPAC activity is increased in arterial endothelial cells exposed to laminar-fluid shear stress, activation of EPAC1, and its activation of Rap1, plays a role in promoting alignment and elongation of these cells in the direction of flow.

  10. EPAC activation consistently reverses clinical and experimental impairment of neutrophil phagocytosis. EPAC signals through Rap-1 (zeige RABGEF1 Proteine) and bypasses RhoA (zeige RHOA Proteine). EPAC activation represents a novel potential means by which to reverse impaired neutrophil phagocytosis.

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Interaktionspartner

  1. 2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (zeige CNR1 Proteine) receptors. Among the six isoforms of phospholipase C (PLC (zeige PLC Proteine); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (zeige PLCE1 Proteine), PLCzeta (zeige PLCz1 Proteine), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (zeige DHDDS Proteine)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...

  2. Data suggest that Epac1 reduces formation of the NLRP3 (zeige NLRP3 Proteine) inflammasome to reduce inflammatory responses in the retinal vasculature.

  3. Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (zeige LEP Proteine) expression and secretion in white adipose tissue.

  4. data demonstrate that endogenous PGE2, EP2 (zeige SPAG11A Proteine) receptors, and EPAC are prerequisites for maximal LPS (zeige TLR4 Proteine)-induced IL-33 (zeige IL33 Proteine) expression and that exogenous PGE2 can amplify IL-33 (zeige IL33 Proteine) production via EP2 (zeige SPAG11A Proteine) and EP4 (zeige PTGER4 Proteine) receptors.

  5. Epac1 is involved in AC5 (zeige ADCY5 Proteine)-mediated catecholamine stress-induced cardiac fibrosis. Epac1 is involved in AC5 (zeige ADCY5 Proteine)-mediated elongation of atrial fibrillation.

  6. Within heart mitochondria, different Epac1 microdomains control myocardial cell death.

  7. GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain, inhibiting agonist-induced Epac1 translocation to the plasma membrane, reducing Rap1 activation.

  8. DPP4i restores cardiac remodeling and apoptosis caused by the pathological decline in circulating GLP-1 in response to pressure overload. EPAC1 is essential for cardiomyocyte survival via the cAMP/Rap1 activation independently of PKA.

  9. Epac2 (zeige RAPGEF4 Proteine), but not Epac1 has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  10. Epac1 deficiency attenuates neointima formation through, at least in part, inhibition of SMC (zeige DYM Proteine) migration, in which a decrease in Ca(2 (zeige CA2 Proteine)+) influx and a suppression of cofilin (zeige CFL1 Proteine)-mediated lamellipodia formation occur.

Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Protein Überblick

Protein Überblick

binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner

Alternative names and synonyms associated with Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3)

  • Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3)
  • Rap guanine nucleotide exchange factor (GEF) 3 (rapgef3)
  • Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3)
  • 2310016P22Rik Protein
  • 9330170P05Rik Protein
  • bcm910 Protein
  • CAMP-GEFI Protein
  • Epac Protein
  • Epac1 Protein
  • HSU79275 Protein
  • RAPGEF3 Protein
  • si:dkey-27m20.2 Protein

Bezeichner auf Proteinebene für RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3 , RAP guanine-nucleotide-exchange factor 3 , exchange protein directly activated by cAMP 1 , rap guanine nucleotide exchange factor 3 , Rap1 guanine-nucleotide exchange factor , rap guanine nucleotide exchange factor 3-like , 9330170P05Rik , EPAC 1 , Rap1 guanine-nucleotide-exchange factor directly activated by cAMP , cAMP-regulated guanine nucleotide exchange factor I , exchange factor directly activated by cAMP 1 , cAMP-GEFI , cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) , epac 1

GENE ID SPEZIES
426888 Gallus gallus
467198 Pan troglodytes
486591 Canis lupus familiaris
535383 Bos taurus
703967 Macaca mulatta
733186 Xenopus laevis
100174087 Pongo abelii
100320646 Danio rerio
100399583 Callithrix jacchus
100473947 Ailuropoda melanoleuca
100560594 Anolis carolinensis
10411 Homo sapiens
223864 Mus musculus
59326 Rattus norvegicus
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