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None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 (zeige PRKD1 ELISA Kits) somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 (zeige PRKD3 ELISA Kits) genes.
investigated the interaction network of human PKD2 in the cytosol and in Golgi-enriched subcellular protein fractions
SNX3 (zeige SNX3 ELISA Kits)-retromer complex regulates the surface expression and function of PC1 (zeige PCSK1 ELISA Kits) and PC2 (zeige KRT6B ELISA Kits)
We aimed to revisit PKD2 prevalence, clinical presentation, mutation spectrum, and prognosis through the Genkyst cohort. Patients with PKD2-related dominant polycystic kidney disease typically present with mild disease
Hyperactivation of the ERK (zeige EPHB2 ELISA Kits) pathway may be caused by down-regulation of PC-1 (zeige PCSK1 ELISA Kits) and PC-2 (zeige KRT6B ELISA Kits) in lymphatic malformations, contributing to increased proliferation of lymphatic endothelial cells.
Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1 (zeige PKD1 ELISA Kits)-T, PKD1 (zeige PKD1 ELISA Kits)-NT and PKD2 mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.
Here, we review previous studies that connect the molecular properties of the domains of PC2 (zeige KRT6B ELISA Kits) Cterm to distinct aspects of PC2 (zeige KRT6B ELISA Kits) functions and regulation.
Data show that in 82 (87.2%) of the patients, pathogenic mutations were detected in PKD1 (zeige PKD1 ELISA Kits) (79.0%-92.5%), whereas in 12 (12.8%) patients pathogenic mutations were detected in PKD2 (7.5%-21.0%).
Two cryo-EM structures of distinct channel states of full-length human PC2 (zeige KRT6B ELISA Kits) in complex with lipids and cations.
The structure of human PC2 (zeige KRT6B ELISA Kits) in a closed conformation, solved by electron cryomicroscopy at 4.2-A resolution.
Our studies demonstrate that PKD1 (zeige PKD1 ELISA Kits)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (zeige DGKA ELISA Kits) effect on MVB secretory traffic.
Results reveal that whereas protein kinase D1 (zeige PRKD1 ELISA Kits) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (zeige CD8A ELISA Kits)(+) T cells that became effector cells.
Protein kinase D2 promotes in vitro osteoclast differentiation and fusion
A bioinformatic screen identified the serine-threonine kinase (zeige CDK4 ELISA Kits) protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells
Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells.
PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC (zeige PKC ELISA Kits) isoforms, in particular, PKCdelta (zeige PKCd ELISA Kits) activate PKD2 in platelets.
Data demonstrate that, unlike PKD1 (zeige PKD1 ELISA Kits), PKD2 catalytic activity is dispensable for normal embryogenesis.
PKD2, like PKD (zeige PRKD1 ELISA Kits), facilitates mitogenesis in 3T3 cells
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
serine/threonine-protein kinase D2
, protein kinase D2
, serine/threonine-protein kinase D2-like