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Low PDE7A expression is associated with sepsis.
PDE7A is a high-speed and low-affinity phosphodiesterase for cCMP.
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells; PDE7A was expressed in neutrophils and alveolar macrophages
crystal structure of PDE7A1 catalytic domain complexed with the inhibitor 3 (zeige PPP1R11 ELISA Kits)-isobutyl-1-methylxanthine & kinetic analysis on mutant PDE7A1 and PDE4D2; results show several residues must work together to switch inhibitor selectivity between PDE4 (zeige PDE4A ELISA Kits) & PDE7
PDE7A is not essential for activation of T lymphocytes; its inactivation by targeted gene disruption appears to enhance in vivo humoral immune responses.
results demonstrate that PDE7A might regulate TNF-alpha (zeige TNF ELISA Kits) production in keratinocytes in a cAMP-dependent fashion
PDE7A is involved in regulation of cell proliferation and cytokine production of NKT (zeige CTSL1 ELISA Kits) cells.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
phosphodiesterase 7A, like
, phosphodiesterase 7A
, high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
, high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
, high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A-like
, phosphodiesterase isozyme 7
, rolipram-insensitive phosphodiesterase type 7