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Paralemmin-1 is expressed in normal and tumor-derived lymphatic endothelial cells. It represses cell migration and delays the formation of tube-like lymphatic structures by modulating cell adhesion, filopodia formation and plasma membrane blebbing.
Expression of Palm in the mouse striatum is modulated by a sequence variant (B2 SINE indel) in the 3' UTR (zeige UTS2R ELISA Kits) of Comt (catechol-O-methyltransferase (zeige COMT ELISA Kits)).
report that palmitoylation-deficient (Palm(-/-)) mice carrying two Cys (zeige DNAJC5 ELISA Kits) to Thr (zeige TRH ELISA Kits) and Ser (zeige SIGLEC1 ELISA Kits) mutations in the opsin (zeige RHO ELISA Kits) gene displayed profound light-induced retinal degeneration that first involved rod and then cone cells.
This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.