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Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2 (zeige ADRBK1 ELISA Kits)/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 activity.
Gpr3 stimulates Abeta (zeige APP ELISA Kits) production via interactions with APP (zeige APP ELISA Kits) and beta-arrestin2 (zeige ARRB2 ELISA Kits).
GPR3 is a key factor in the regulation of the nervous system and follicle development.[review]
GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse.
Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women.
We conclude that perturbations in GPR3 are not a common explanation for POF (zeige POF1B ELISA Kits) in this population.
GPR3 appears to have a key role in the thermogenic response of interscapular brown adipose tissue and may represent a new therapeutic target in age-related obesity.
This study found that the expression of GPR3 in CGNs exerted prosurvival effects against apoptosis-inducing stimuli, such as potassium deprivation, hypoxia, and ROS (zeige ROS1 ELISA Kits).
Altered signalling pathways of GPR3 could contribute to the neurobiological substrate involved in developing addiction to cocaine
Involvement of the orphan GPR3 receptor is demonstrated for the first time in expression and development of neuropathic pain and in analgesia induced by morphine.
the GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle and is crucial for the regulation of meiosis
Gpr3-defective mice may constitute a relevant model of premature ovarian failure due to early oocyte aging.
the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12 (zeige GPR12 ELISA Kits)
GPR3 specifically in the oocyte, rather than in the follicle cells, is responsible for maintenance of meiotic arrest in mouse oocytes.
GPR3-G(s) activation in response to stimulation of an exogenously expressed beta(2)-adrenergic receptor (zeige ADRB2 ELISA Kits) causes Galpha (zeige SUCLG1 ELISA Kits)(s) to move from the oocyte plasma membrane into the cytoplasm.
Gpr3 is epistatic to Pde3a (zeige PDE3A ELISA Kits) and fertility as well as meiotic arrest in the PDE3A (zeige PDE3A ELISA Kits)-deficient oocyte is dependent on the activity of GPR3.
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
G protein-coupled receptor 3
, ACCA orphan receptor
, G-protein coupled receptor 3
, adenylate cyclase constitutive activator
, G protein-coupled receptor R4
, G-protein-coupled receptor R4