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Gpr161 is an A-kinase anchoring protein (zeige AKAP13 ELISA Kits) and the cAMP-sensing Gpr161:PKA complex acts as cilium-compartmentalized signalosome
Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor (zeige ADRA1A ELISA Kits) Gpr161 from the primary cilium.
G-protein-coupled receptor (zeige ADRA1A ELISA Kits) GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
False positive non-synonymous polymorphisms of G-protein coupled receptor (zeige ADRA1A ELISA Kits) genes.
Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor (zeige GPR34 ELISA Kits) Gpr161 from the primary cilium.
Gpr161 is a G-protein coupled receptor (zeige GPR34 ELISA Kits) that regulates the retinoic acid and canonical Wnt (zeige WNT2 ELISA Kits) pathways during neurulation
Complete loss of Gpr161 in mouse causes midgestation lethality and increased Shh (zeige SHH ELISA Kits) signaling in the neural tube, phenocopying Tulp3 (zeige TULP3 ELISA Kits)/IFT-A mutants.
Characterization of the vl mutation indicates that C-terminal tail of Gpr161 is truncated, leading to multiple effects on the protein, including reduced receptor-mediated endocytosis
Gpr161 is required for left-right patterning.
Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008
G protein-coupled receptor 161
, G-protein coupled receptor 161
, G-protein coupled receptor 161-like
, G-protein coupled receptor RE2