anti-Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antikörper

Bezeichnung:
anti-Egl Nine Homolog 1 (C. Elegans) Antikörper (EGLN1)
Auf www.antikoerper-online.de finden Sie aktuell 161 Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Egl Nine Homolog 1 (C. Elegans) Kits (8) und Egl Nine Homolog 1 (C. Elegans) Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 178 Egl Nine Homolog 1 (C. Elegans) Produkte verfügbar.
Synonyme:
AI503754, C1orf12, ECYT3, EGLN1, egln2, Hif-p4h-2, HIF-PH2, HIFPH2, HPH-2, HPH2, ORF13, PHD-2, PHD2, SM-20, SM20, zgc:92314, ZMYND6
Alle Antikörper anzeigen Gen GeneID UniProt
EGLN1 112405 Q91YE3
EGLN1 308913  
EGLN1 54583 Q9GZT9

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Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antikörper

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Am meisten referenzierte anti-Egl Nine Homolog 1 (C. Elegans) Antikörper

  1. Human Polyclonal EGLN1 Primary Antibody für FACS, ICC - ABIN151071 : Elvidge, Glenny, Appelhoff, Ratcliffe, Ragoussis, Gleadle: Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. in The Journal of biological chemistry 2006 (PubMed)
    Zeige alle 66 Referenzen für 151071

  2. Human Polyclonal EGLN1 Primary Antibody für ICC, IF - ABIN250635 : Mikhaylova, Ignacak, Barankiewicz, Harbaugh, Yi, Maxwell, Schneider, Van Geyte, Carmeliet, Revelo, Wyder, Greis, Meller, Czyzyk-Krzeska: The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. in Molecular and cellular biology 2008 (PubMed)
    Zeige alle 23 Referenzen für 250635

  3. Human Polyclonal EGLN1 Primary Antibody für EM, FACS - ABIN151072 : Baek, Mahon, Oh, Kelly, Krishnamachary, Pearson, Chan, Giaccia, Semenza: OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. in Molecular cell 2005 (PubMed)
    Zeige alle 16 Referenzen für 151072

  4. Human Monoclonal EGLN1 Primary Antibody für IHC, IHC (p) - ABIN440716 : Stolze, Tian, Appelhoff, Turley, Wykoff, Gleadle, Ratcliffe: Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 4 Referenzen für 440716

  5. Human Polyclonal EGLN1 Primary Antibody für ELISA, WB - ABIN565755 : Aprelikova, Pandolfi, Tackett, Ferreira, Salnikow, Ward, Risinger, Barrett, Niederhuber: Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. in Cancer research 2009 (PubMed)

  6. Cow (Bovine) Polyclonal EGLN1 Primary Antibody für WB - ABIN2775907 : Appelhoff, Tian, Raval, Turley, Harris, Pugh, Ratcliffe, Gleadle: Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. in The Journal of biological chemistry 2004 (PubMed)

Weitere Antikörper gegen Egl Nine Homolog 1 (C. Elegans) Interaktionspartner

Xenopus laevis Egl Nine Homolog 1 (C. Elegans) (EGLN1) Interaktionspartner

  1. oxygen via Phd2 has a decisive influence on the formation of the vascular network during vertebrate embryogenesis.

  2. comparative analysis of phd1 (zeige EGLN2 Antikörper), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 1 (C. Elegans) (EGLN1) Interaktionspartner

  1. Epo (zeige EPO Antikörper) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 and PHD3 (zeige EGLN3 Antikörper), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.

  2. Notch ligand (zeige JAG2 Antikörper) genes Jag1 (zeige JAG1 Antikörper), Jag2 (zeige JAG2 Antikörper), and Dll1 (zeige DLL1 Antikörper) and target Hes1 became downregulated upon aging HIF-2alpha (zeige EPAS1 Antikörper) dependently.

  3. Results identified a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct impact on their function.

  4. Results found that loss of endothelial PHD2 induced pulmonary arterial hypertension and vascular remodeling in a HIF-2-dependent fashion.

  5. We conclude that the activation of the HIF pathway induced by PHD2 deficiency enhances the effect of running training

  6. deleting Phd1 (zeige EGLN2 Antikörper)-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.

  7. Key messages: HIF-P4H-2 deficiency protects skeletal muscle from ischemia-reperfusion injury. The mechanisms involved are mediated via normoxic HIF-1alpha (zeige HIF1A Antikörper) and HIF-2alpha (zeige EPAS1 Antikörper) stabilization. HIF-P4H-2 deficiency increases capillary size but not number. HIF-P4H-2 deficiency maintains energy metabolism during ischemia-reperfusion.

  8. Diminished degradation of FLNA upon PHD2 inactivation in hypoxia rearranges the actin cytoskeleton to reduce the number of dendritic spines, synapses.

  9. Stabilized HIF-1alpha (zeige HIF1A Antikörper) induced by PHD2 conditional knockout resulted in the transition of muscle fibers toward a slow fiber type via a calcineurin/NFATc1 (zeige NFATC1 Antikörper) signaling pathway.

  10. HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis.

Human Egl Nine Homolog 1 (C. Elegans) (EGLN1) Interaktionspartner

  1. Genetic variants in HIF-1alpha (zeige HIF1A Antikörper) and PHD2 genes exist in Caucasians but do not appear to alter 30-day mortality in sepsis

  2. Results identified a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct impact on their function.

  3. The role of PHD-2 in breast cancer [review]

  4. Sulfur mustard negatively affects hypoxia-stimulated HIF-1alpha (zeige HIF1A Antikörper) signaling in keratinocytes and fibroblasts and thus possibly contributes to delayed wound healing in SM-injured patients, which could be treated with PHD-2 inhibitors.

  5. The HIFalpha subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. Study confirmed that triple-negative breast cancer cells secrete glutamate (zeige GRIN1 Antikörper), which is both necessary and sufficient for the paracrine induction of HIF1alpha (zeige HIF1A Antikörper) in such cells under normoxic conditions.

  6. Disulfide bond-mediated PHD2 dimerization and inactivation result in the activation of HIF-1alpha (zeige HIF1A Antikörper) and aerobic glycolysis in response to oxidative stress.

  7. The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2/HIF-1alpha (zeige HIF1A Antikörper) signaling pathway.

  8. the levels of both miR (zeige MLXIP Antikörper)-182 and HIF1alpha (zeige HIF1A Antikörper) were elevated, while the expression PHD2 and FIH1 (zeige HIF1AN Antikörper) was downregulated in a mouse model of prostate cancer.

  9. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (zeige KAT2B Antikörper)) activation

  10. In this article, UTMD/PEI mediated gene transfection was investigated and the US parameters were optimized. Furthermore, the biological effects of PHD2 shRNA were investigated in H9C2 cells.

Egl Nine Homolog 1 (C. Elegans) (EGLN1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Alternative names and synonyms associated with Egl Nine Homolog 1 (C. Elegans) (EGLN1)

  • egl nine homolog 1 (C. elegans) (EGLN1) Antikörper
  • egl nine homolog 1 (egln1) Antikörper
  • egl nine homolog 1 (C. elegans) (egln1) Antikörper
  • EGL nine homolog 1 (C. elegans) (Egln1) Antikörper
  • egl-9 family hypoxia-inducible factor 1 (EGLN1) Antikörper
  • AI503754 Antikörper
  • C1orf12 Antikörper
  • ECYT3 Antikörper
  • EGLN1 Antikörper
  • egln2 Antikörper
  • Hif-p4h-2 Antikörper
  • HIF-PH2 Antikörper
  • HIFPH2 Antikörper
  • HPH-2 Antikörper
  • HPH2 Antikörper
  • ORF13 Antikörper
  • PHD-2 Antikörper
  • PHD2 Antikörper
  • SM-20 Antikörper
  • SM20 Antikörper
  • zgc:92314 Antikörper
  • ZMYND6 Antikörper

Bezeichner auf Proteinebene für EGLN1

egl nine homolog 1 (C. elegans) , egl nine homolog 1 , egl nine homolog 1-like , egl nine homolog 2 , Hif-p4h-2 , HIF-prolyl hydroxylase 2 , hypoxia-inducible factor prolyl hydroxylase 2 , prolyl hydroxylase domain-containing protein 2 , HIF prolyl hydroxylase 2 , egl nine-like protein 1 , zinc finger MYND domain-containing protein 6

GENE ID SPEZIES
421528 Gallus gallus
469708 Pan troglodytes
534075 Bos taurus
100153461 Sus scrofa
100454843 Pongo abelii
100594374 Nomascus leucogenys
446395 Xenopus laevis
436868 Danio rerio
488971 Canis lupus familiaris
112405 Mus musculus
308913 Rattus norvegicus
54583 Homo sapiens
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