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Gene deletion studies demonstrated for the first time that lack of NFM (zeige CEBPB ELISA Kits) leads to changes of D1R (zeige DRD1 ELISA Kits)-mediated long-term potentiation and D1R (zeige DRD1 ELISA Kits)-mediated behavior
Data conclude that NF-H (zeige NEFH ELISA Kits) and NF-M (zeige CEBPB ELISA Kits) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.
Computational modeling predicted that an expanded NF-M C terminus extended farther from the neurofilament core independent of lysine-serine-proline (KSP) phosphorylation.
results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H (zeige NEFH ELISA Kits) and NF-M (zeige CEBPB ELISA Kits)
Data show that the tail domain of neurofilament subunit NF-M (zeige CEBPB ELISA Kits), with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.
results demonstrate NF-M (zeige CEBPB ELISA Kits) tail-mediated interactions of neurofilaments, independent of NF transport rate, are critical determinants of the size and cytoskeletal architecture of axons and are mediated in part by the highly phosphorylated tail domain of NF-M (zeige CEBPB ELISA Kits)
NF-M regulates the association of NFs with kinesin.
Alpha-internexin (zeige INA ELISA Kits) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (zeige CEBPB ELISA Kits) alone or together with NF-H (zeige NEFH ELISA Kits) in mice reduces alpha-internexin (zeige INA ELISA Kits) transport & content in axons throughout the CNS.
data indicate that a blockade of NMDA receptors during development of cortical neurons increases the phosphorylation state and the solubility of NF-M (zeige CEBPB ELISA Kits), thereby favoring neurite outgrowth
Phosphorylation of NF-M (zeige CEBPB ELISA Kits) lysine-serine-proline (KSP) repeats is not an essential component for the acquisition of normal axonal caliber mediated by myelin-dependent outside-in signaling.
NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R (zeige DRD1 ELISA Kits) internalization from the plasma membrane in Adosterone-producing Adenomas.
direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease
the importance of alpha-internexin (zeige INA ELISA Kits) and NF-L (zeige NEFL ELISA Kits) in regulating the conformations of NF-M and NF-H (zeige NEFH ELISA Kits)
To study if the increase of levels of neurofilament (NF)-M and NF-L (zeige NEFL ELISA Kits) in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L (zeige NEFL ELISA Kits).
Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients.
O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role.
variation in NEF3 influence rate of response to typical antipsychotic medication
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
neurofilament protein M
, neurofilament, medium polypeptide 150kDa
, neurofilament triplet M protein
, CCAAT box/enhancer binding protein beta
, CCAAT/enhancer-binding protein beta
, CCR protein
, c/EBP beta
, transcription factor NF-M
, 160 kDa neurofilament protein
, major neuronal intermediate filament subunit
, neurofilament 3
, neurofilament M subunit
, neurofilament medium polypeptide
, Neurofilament protein, middle polypeptide
, neurofilament 3, medium
, neurofilament-3 (150 kD medium)
, NF-M c-terminus
, NF-M protein
, neurofilament 3 (150kDa medium)
, middle molecular weight neurofilament protein NF-M(1)