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Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3 (zeige LAMA3 ELISA Kits), 59% carried mutations in both alleles of LAMB3, and 12% were homozygous for mutations in LAMC2 (zeige LAMC2 ELISA Kits). In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3 (zeige LAMA3 ELISA Kits), LAMB3, or LAMC2 (zeige LAMC2 ELISA Kits) was not possible, so the molecular basis of disease could not be clarified completely
the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells.
The expression of fascin-1 (zeige FSCN1 ELISA Kits) and lanminin-5 and the serum levels of fascin-1 (zeige FSCN1 ELISA Kits) and laminin-5 were related to the relapse of patients with non-small cell lung cancer.
Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity
Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations.
Screening of ENAM (zeige ENAM ELISA Kits) and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples.
Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies.
An algorithm combining CLDN10 (zeige CLDN10 ELISA Kits), HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL (zeige CHIC2 ELISA Kits) samples (94% sensitivity and 96% specificity in validation set).
Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity.
we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr).
A new mouse model of junctional epidermolysis bullosa has been characterized by the LAMB3 628G>A knockin mouse.
Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5 (zeige LAMA5 ELISA Kits)) may regulate appropriate hair morphogenesis.
Data show thatincreased mRNA of Lamb3 and Adamts2 (zeige Adamts2 ELISA Kits) and enhanced activities of metalloproteinases MMP1 (zeige MMP1 ELISA Kits), 2 and 7 in transgenic mice expressing the HLA-DQ8.
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.
laminin, beta 3
, laminin subunit beta-3
, laminin subunit beta-3-like
, epiligrin subunit bata
, kalinin B1 chain
, kalinin subunit beta
, laminin B1k chain
, laminin S B3 chain
, laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD))
, laminin-5 subunit beta
, nicein subunit beta
, nicein, 125kD
, nicein, 125kDa
, laminin chain