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anti-Mouse (Murine) SPARC Antikörper:
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Mouse (Murine) Polyclonal SPARC Primary Antibody für CyTOF, FACS - ABIN4899335
Arnold, Rivera, Carbon, Toombs, Chang, Bradshaw, Brekken: Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGF? activation. in PLoS ONE 2012
Show all 9 Pubmed References
Human Polyclonal SPARC Primary Antibody für CyTOF, FACS - ABIN4899340
Aguilera, Rivera, Hur, Carbon, Toombs, Goldstein, Dellinger, Castrillon, Brekken: Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. in Cancer research 2014
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Mouse (Murine) Monoclonal SPARC Primary Antibody für CyTOF, FACS - ABIN4899334
Weaver, Sage, Yan: Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. in Journal of cellular biochemistry 2006
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Human Polyclonal SPARC Primary Antibody für IF (p), IHC (p) - ABIN738141
Chen, Wang, Xi, Xue, He, Zhang, Zhao: SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. in PLoS ONE 2012
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Human Polyclonal SPARC Primary Antibody für FACS, WB - ABIN4899336
Xu, Ping, Yin, Xiao, Xiang, Ballantyne, Wu, Li: Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. in PLoS ONE 2013
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Human Polyclonal SPARC Primary Antibody für IHC, IHC (fro) - ABIN4355498
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
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Human Monoclonal SPARC Primary Antibody für CyTOF, FACS - ABIN4899338
Moreno, Ball, Andrade, McDermid, Stanimirovic: Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. in Glia 2006
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Human Monoclonal SPARC Primary Antibody für CyTOF, FACS - ABIN4899339
Grønborg, Kristiansen, Iwahori, Chang, Reddy, Sato, Molina, Jensen, Hruban, Goggins, Maitra, Pandey: Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. in Molecular & cellular proteomics : MCP 2006
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Human Monoclonal SPARC Primary Antibody für ELISA, WB - ABIN562974
Piconese, Costanza, Tripodo, Sangaletti, Musio, Pittoni, Poliani, Burocchi, Passafaro, Gorzanelli, Vitali, Chiodoni, Barnaba, Pedotti, Colombo: The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses. in Journal of autoimmunity 2011
these data identify a contributory role for DNA methylation (zeige HELLS Antikörper) in regulating sparc expression in zebrafish embryogenesis.
Results establish a role for an ECM (zeige MMRN1 Antikörper) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.
Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.
Sparc is directly required for normal otolith growth
SPARC is regulating the interplay between myeloid-derived suppressor cells and the extracellular matrix to drive the induction of epithelial-to-mesenchymal transition in tumor cells.
The results demonstrate for the first time a functional role of the N-propeptide in regulating collagen fiber assembly and cell behavior and suggest that SPARC and the N-propeptide of collagen I have distinct activities in regulating collagen fiber assembly and fibroblast function.
SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved.
An ADAMTS1 (zeige ADAMTS1 Antikörper) blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 (zeige ADAMTS1 Antikörper) interaction. In conclusion, ADAMTS1 (zeige ADAMTS1 Antikörper) is an important mediator of SPARC-regulated cardiac aging.
SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function
resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.
SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (zeige STS Antikörper) migration.
SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.
SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.
Tumor-produced SPARC and VCAM1 (zeige VCAM1 Antikörper) are regulators of cancer extravasation.
The SPARC drives pathological responses in non-small cell lung cancer and idiopathic pulmonary fibrosis by promoting microvascular remodelling and excessive deposition of ECM (zeige MMRN1 Antikörper) proteins.
proCOL11A1, fibroblast-activated protein, secreted protein acidic and rich in cysteine, and periostin (zeige POSTN Antikörper) expression was significantly increased in the intratumoral stroma of pancreatic ductal adenocarcinomas compared to paired non-neoplastic pancreata
The mRNA and protein levels of SPARC were 5.78-fold higher in cancer tissues compared with the case-matched normal epithelium. High expression levels of SPARC in esophageal squamous cell carcinoma parenchyma were related to lymph node metastasis and poor prognosis (p = 0.049 and p = 0.04).
SPARC can serve a dual function role as both predictor for prognosis and potentially biomarker for lymph node metastasis in resected pancreatic cancer patients.
that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors
WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action
high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test
We identified five new biomarkers: GDF15 (zeige GDF15 Antikörper), osteonectin, TRAP5, TWEAK (zeige TNFSF12 Antikörper), and YKL40 (zeige CHI3L1 Antikörper) as being promising markers for monitoring bone metastases.
findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition
This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (zeige VEGFA Antikörper)), fibroblast growth factor 2 (FGF2 (zeige FGF2 Antikörper)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.
data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.
, basement-membrane protein 40
, secreted protein acidic and rich in cysteine
, cysteine-rich protein
, Secreted acidic cystein-rich glycoprotein (osteonectin)
, secreted acidic cysteine rich glycoprotein