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These findings thus identify Bif-1 as a novel regulator of lipid homeostasis to prevent the pathogenesis of obesity and its associated metabolic complications.
these data reveal an Irgm1 (zeige IRGM ELISA Kits)-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy
Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis
selective autophagy regulates the basal and atrophy-induced turnover of the pentameric transmembrane protein, CHRN, and that TRIM63 (zeige TRIM63 ELISA Kits), together with SH3GLB1 and SQSTM1 (zeige SQSTM1 ELISA Kits) regulate this process.
these data suggest that Bif-1 is essential for the maintenance of mitochondrial morphology and function in neurons
Bif-1 haploinsufficiency attenuates mitophagy and results in the promotion of chromosomal instability, which enables tumor cells to efficiently bypass the oncogenic/metabolic pressures for apoptosis.
findings not only establish Cdk5 (zeige CDK5 ELISA Kits) as a critical regulator of autophagy induction, but also reveal a role for Cdk5 (zeige CDK5 ELISA Kits) and EndoB1 in the pathophysiology of Parkinson's disease through modulating autophagy
These findings suggest that Bif-1 acts as a critical regulator of Atg9 (zeige ATG9A ELISA Kits) puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation.
Bif-1 is an important component of the mitochondrial pathway for apoptosis as a novel Bax (zeige BAX ELISA Kits)/Bak (zeige BAK1 ELISA Kits) activator, and loss of this proapoptotic molecule may contribute to tumorigenesis.
A potential role for endophilin B1t (zeige TUBB ELISA Kits) in mammalian spermatogenesis is discussed within the context of the PP1c gamma knockout testis phenotype.
endophilin B1 participates in dynamin 2 (zeige DNM2 ELISA Kits)-dependent formation of a population of transport vesicles distinct from those generated by A-type endophilins
Bif-1 (zeige ZBTB24 ELISA Kits) is involved in prostate cancer tumorigenesis and acts as a suppressor in prostate cancer progression.
endophilin B1 mediated the biological function of EGFR (zeige EGFR ELISA Kits) in cancer cell proliferation through regulating the EGFR (zeige EGFR ELISA Kits) endocytic trafficking and downstream signaling.
these data reveal an Irgm1 (zeige IRGM ELISA Kits)-dependent mechanism that promotes the tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1 (zeige ZBTB24 ELISA Kits)-dependent autophagy
Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5 (zeige ATG5 ELISA Kits), Ambra1 (zeige AMBRA1 ELISA Kits), beclin-1 (zeige BECN1 ELISA Kits), LC3B (zeige MAP1LC3B ELISA Kits) and Bif-1 (zeige ZBTB24 ELISA Kits) is significantly correlated with poor outcome.
these data suggest a novel function for Bif-1 (zeige ZBTB24 ELISA Kits) as a suppressor of breast cancer cell migration by promoting EGFR (zeige EGFR ELISA Kits) degradation through the regulation of endosome maturation
The expression of Bif-1 (zeige ZBTB24 ELISA Kits) is downregulated in a subset of pancreatic ductal adenocarcinoma. This novel finding is in agreement with the tumor suppressor function of Bif-1 (zeige ZBTB24 ELISA Kits).
These findings suggest that Bif-1 (zeige ZBTB24 ELISA Kits) acts as a critical regulator of Atg9 (zeige ATG9A ELISA Kits) puncta formation presumably by mediating Golgi fission for autophagosome biogenesis during starvation.
GSK-3beta (zeige GSK3b ELISA Kits) promotes cell survival by modulating Bif-1 (zeige ZBTB24 ELISA Kits)-dependent autophagic response and cell death.
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants.
SH3-domain GRB2-like endophilin B1
, SH3 domain-containing GRB2-like protein B1
, Bax-interacting factor 1
, SH3-containing protein SH3GLB1
, protein phosphatase 1, regulatory subunit 70
, SH3-domain GRB2-like B1 (endophilin)
, SH3 domain GRB2-like protein B1