MMP14 Proteine (MMP14)

Bezeichnung:
Matrix Metallopeptidase 14 (Membrane-inserted) Proteine (MMP14)
Auf www.antikoerper-online.de finden Sie aktuell 27 Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MMP14 Antikörper (263) und MMP14 Kits (28) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 332 MMP14 Produkte verfügbar.
Synonyme:
AI325305, MMP-14, MMP-X1, MMP1, MT-MMP, MT-MMP-1, MT-MMP 1, Mt1-mmp, MT1MMP, MTMMP1, sabe
alle Proteine anzeigen Gen GeneID UniProt
MMP14 4323 P50281
MMP14 17387 P53690
MMP14 81707 Q10739

Weitere Synonyme anzeigen

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Weitere Proteine zu MMP14 Interaktionspartnern

Human Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. MT1-MMP-expressing cells induced co-cultured non-MT1-MMP-expressing cells.

  2. The mechanism of transition from nondifferentiated to differentiated states in HepaRG cells was studied by proteomics. Two key factors (MMP-14 and OCLN (zeige OCLN Proteine)) were validated by qRT-PCR and Western blot. Blockade of MMP-14 further demonstrated its important function during tumor cell migration.

  3. Data suggest that phosphorylation of Thr567 in cytoplasmic tail of MT1-MMP (MMP14) influences behavior of both individual ovarian cancer cells and multicellular aggregates; tumor cells expressing MT1-MMP-T567E phosphomimetic mutant exhibit enhanced cell migration and enhanced cell adhesion to peritoneum and other biological surfaces.

  4. MMP-14 Is a novel substrate for matriptase (zeige ST14 Proteine), which regulates the levels of MMP-14 on the cell surface. High levels of matriptase (zeige ST14 Proteine) in alpha-1 antitrypsin (zeige SERPINA1 Proteine) deficiency may contribute to increased extracellular matrix degradation by alveolar macrophages both directly and through MMP-14 activation.

  5. High expression of MMP14 and CDK7 (zeige CDK7 Proteine) was independent prognostic factors for overall survival in patients with gastric cancer.

  6. only collagen-IV (zeige COL4 Proteine) elicits the formation of proteolytically active podosomes through a mechanism involving increased Src (zeige SRC Proteine) phosphorylation, p190RhoGAP (zeige GRLF1 Proteine)-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites.

  7. This study demonstrates that excessive ECM (zeige MMRN1 Proteine) degradation mediated by high levels of MT1-MMP is not associated with cell migration and tumourigenesis, while low levels of MT1-MMP promote invasion and vascularization in vivo.

  8. DDR2 (zeige DDR2 Proteine) mediates collagen-induced activation of MT1-MMP in human fibroblasts

  9. results suggest that the cytoplasmic domain regulates MT1-MMP function in a manner required for cell survival, but is dispensable for cell migration

  10. MMP14 plays an important mechanistic role in NSCLC progression, by supporting cancer invasiveness, promoting collagen degradation, and releasing HB-EGF (zeige HBEGF Proteine), which accelerates lung tumor progression.

Mouse (Murine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 and MMP15 (zeige MMP15 Proteine) in regulating mammary gland adipocyte differentiation. Whereas MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 (zeige MMP15 Proteine) differentially controls the formation of thermogenic brown fat.

  2. The authors identified the membrane-tethered matrix metalloprotease (zeige ADAMTS7 PLURAL_@34830@) MT1-MMP as a prominent host-extracellular matrix-remodeling collagenase in influenza infection.

  3. MMP-14 expression in fibroblasts plays a crucial role in collagen remodeling in adult skin and largely contributes to dermal homeostasis underlying its pathogenic role in fibrotic skin disease in a mouse model

  4. MT1-MMP directly cleaves LYVE-1 (zeige LYVE1 Proteine) on lymphatic endothelial cells to inhibit LYVE-1 (zeige LYVE1 Proteine)-mediated lymphangiogenic responses and restrains the production of VEGF-C (zeige VEGFC Proteine).

  5. The authors propose a model for cell-regulated collagen fibril assembly during tendon development in which MMP14 cleaves a molecular bridge tethering collagen fibrils to the plasma membrane of fibripositors.

  6. We demonstrate that MMP-14-mediated signaling in fetal hepatic progenitor cells promotes biliary luminal formation around the portal vein and negatively controls the maturation of hepatocytes.

  7. Results show a reciprocal association between levels of heparanase (zeige HPSE Proteine) and MMP14, a membrane-bound MMP, shedding light on how branching occurs within developing mammary glands.

  8. MT1-MMP proteolytic activity is required for maintaining cell integrity, loss of MT1-MMP causes cell senescence and nuclear defects.

  9. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 (zeige TIMP1 Proteine) and TIMP2 (zeige TIMP2 Proteine) correlates negatively with the invasive potential of cells.

  10. Angiotensin II suppresses RECK (zeige RECK Proteine), but induces matrix metalloproteinases both in vivo and in vitro.

Cow (Bovine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. results suggest that ET-1 (zeige EDN1 Proteine)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Proteine)-PKCalpha (zeige PKCa Proteine)-p(38)MAPK (zeige MAPK1 Proteine) and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Proteine) expression in the cells

  2. Data indicate the involvement of PKC-alpha (zeige PKCa Proteine) in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Proteine) expression by NF-kappaB (zeige NFKB1 Proteine)-MT1-MMP-dependent and -independent pathway.

  3. Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2 (zeige MMP2 Proteine); MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.

  4. MMP-14, MMP-2 (zeige MMP2 Proteine) and TIMP-2 (zeige TIMP2 Proteine) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.

  5. Results describe distinct changes in expression of MMP2 (zeige MMP2 Proteine), MMP14, and the metallopeptidase (zeige ECEL1 Proteine) inhibitor TIMP2 (zeige TIMP2 Proteine) between different phases of the estrous cycle indicating an endocrine regulation.

  6. EMMPRIN from the luminal epithelium may regulate the expression of stromal MMP-2 (zeige MMP2 Proteine) and MMP-14 suggesting a role in adhesion and fusion of embryo to luminal epithelium.

  7. MT1-MMP seems to act by inducing tissue remodeling in cartilage

  8. sphingosine 1-phosphate is the predominant serum factor essential for MT1-MMP-dependent migration and morphogenic differentiation of vascular endothelial cells

Rabbit Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. MT1-MMP plays a crucial role in RAGE (zeige AGER Proteine)-activated NADPH oxidase (zeige NOX1 Proteine)-dependent signaling pathways.

  2. MMP-1 (zeige MMP1 Proteine) was involved in osteoarthritis development in rabbit ACLT model and the amount of its expression was related with the degree of cartilage degradation.

Pig (Porcine) Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) Interaktionspartner

  1. Modulation of MT1-MMP activity and microRNA-133a exportation into the myocardial interstitium occurred in the setting of acute myocardial ischemia-reperfusion.

  2. A heterogeneous response in MT1-MMP activity likely contributes to regional dysfunction with ischemia-reperfusion. Subsequent I/R activates a proteolytic cascade within the MI region, contributing to continued adverse remodeling.

  3. PI3K-dependent regulation of MT1-MMP protein synthesis and subsequent activation of latent MMP-2 (zeige MMP2 Proteine) as critical events in neointimal hyperplasia after vascular injury.

  4. Induction of endogenous MMP-14 gene and coexpression of SAF-1 (zeige MAZ Proteine) & MMP-14 in the macrophages present in the atherosclerotic plaque implicate SAF-1 (zeige MAZ Proteine) as a key regulator of MMP-14 gene induction in macrophage cells.

  5. In an isolated left ventricular myocyte ischemia/reperfusion model, hypoxia induced a >70% increase in MT1-MMP abundance in myocytes. Confocal microscopy revealed MT1-MMP internalization during this time & reemergence to the membrane with reperfusion.

MMP14 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Alternative names and synonyms associated with MMP14

  • matrix metallopeptidase 14 (membrane-inserted) (mmp14)
  • matrix metallopeptidase 14 (membrane-inserted) (MMP14)
  • matrix metallopeptidase 14 (membrane-inserted) (Mmp14)
  • AI325305 Protein
  • MMP-14 Protein
  • MMP-X1 Protein
  • MMP1 Protein
  • MT-MMP Protein
  • MT-MMP-1 Protein
  • MT-MMP 1 Protein
  • Mt1-mmp Protein
  • MT1MMP Protein
  • MTMMP1 Protein
  • sabe Protein

Bezeichner auf Proteinebene für MMP14

matric metalloproteinase 14 , matrix metalloproteinase-14 , membrane type 1 metalloprotease , membrane-type-1 matrix metalloproteinase , MMP-14 , MMP-X1 , MT-MMP 1 , MT1MMP , MTMMP1 , Membrane type 1-MMP , matrix metalloproteinase 14 (membrane-inserted) , membrane-type matrix metalloproteinase 1 , type 1 matrix metalloprotease 14 , matrix metalloproteinase 14 membrane-inserted , matrix metalloproteinase 14, membrane-inserted , membrane type 1-matrix metalloproteinase , MT1-MMP , matrix metalloproteinase 14 preproprotein , matrix metallopeptidase 1 (interstitial collagenase) , matrix metalloproteinase 14 , membrane type 1 metalloproteinase , membrane-type 1 matrix metalloproteinase , membrane type-1 metalloproteinase

GENE ID SPEZIES
594950 Xenopus (Silurana) tropicalis
4323 Homo sapiens
17387 Mus musculus
81707 Rattus norvegicus
281915 Bos taurus
100009598 Oryctolagus cuniculus
397471 Sus scrofa
443116 Ovis aries
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