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The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Hpo (zeige GFER Proteine) signaling inhibited Yki (zeige YAP1 Proteine) nuclear localization and activity by phosphorylating Yki (zeige YAP1 Proteine) and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki (zeige YAP1 Proteine) activity through modulating its subcellular localization.
in vivo 14-3-3zeta monomer properties and functionality
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
These observations provide the first direct evidence that a 14-3-3 protein (zeige YWHAE Proteine) functions as a stress-induced molecular chaperone (zeige HSP90AA1 Proteine) that dissolves and renaturalizes thermal-aggregated proteins.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
The expression of zeta isoforms of 14-3-3 protein (zeige YWHAE Proteine) was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1 (zeige GCG Proteine)-dependent mechanisms.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1 (zeige WNT1 Proteine)-Cre mice strongly indicate the importance of 14-3-3 (zeige YWHAQ Proteine) proteins in the development of melanocyte lineages.
Results indicate that HuR (zeige ELAVL1 Proteine) induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
PKCdelta (zeige PKCd Proteine)-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1 (zeige FOXO1 Proteine), even when FOXO1 (zeige FOXO1 Proteine) is phosphorylated as under non-stress conditions
analysis of phosphorylation-dependent interactions of AQP2 (zeige AQP2 Proteine) with 14-3-3theta; and -zeta
14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder.
Ywhaz coordinates adipogenesis in visceral fat.
Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R (zeige CNR1 Proteine)).
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
In the majority of NAFLD treatment groups and time points the most stable gene was YWHAZ.
This study shows that human procaspase-2 interaction with 14-3-3 zeta is governed by phosphorylation at both S139 and S164.
The results highlight a new role of TSC2 in protecting glioblastoma against photodynamic therapy-induced cell death, and TSC2 and YWHAZ as new RIP3 (zeige RIPK3 Proteine) partners.
These results suggest that 14-3-3-zeta is involved in the TLR3 (zeige TLR3 Proteine)-TICAM-1 (zeige TICAM1 Proteine) pathway in promoting multimerization of TICAM-1 (zeige TICAM1 Proteine) for the formation of a TICAM-1 (zeige TICAM1 Proteine) signalosome.
The data indicate that microtubule-bound tau is resistant to 14-3-3zeta-induced tau aggregation and suggest that tau phosphorylation promotes tau aggregation in the brain by detaching tau from microtubules and thus making it accessible to 14-3-3zeta.
Structural interface between LRRK2 (zeige LRRK2 Proteine) and 14-3-3 delta protein has been presented.
14-3-3zeta-mediated invasion of cancer cells was found to upregulate Snail (zeige SNAI1 Proteine) through the activation of atypical protein kinase C (zeige PRKCZ Proteine) (aPKC).
The 14-3-3 (zeige YWHAQ Proteine) family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon (zeige YWHAE Proteine), theta and zeta isoforms could be useful indicators of disease severity.
14-3-3zeta regulates HIF-1alpha (zeige HIF1A Proteine) production in hepatocellular carcinoma cells by directly binding to HIF-1alpha (zeige HIF1A Proteine) and via PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/NF-small ka, CyrillicB signal transduction pathway.
this study suggests that the down-regulation of 14-3-3 zeta leads to the inhibition of TGFb1 (zeige TGFB1 Proteine)- induced contraction by decreasing the expression of total RhoA (zeige RHOA Proteine) in TM cells.
Caspase-2 (zeige CASP2 Proteine) phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in YWHAZ.
identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
, D14 3 3 protein
, complementation group K
, leonardo 14-3-3
, 14-3-3 protein zeta
, 14-3-3 zeta
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
, 14-3-3 protein zeta/delta
, tyrosine 3-monooxygenase protein zeta polypeptide
, 14 - 3 - 3 - zeta isoform
, protein kinase C zeta type
, 14-3-3 protein beta
, 14-3-3 protein beta/alpha
, protein kinase C inhibitor protein 1
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
, 14-3-3 protein beta-subtype
, 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
, prepronerve growth factor RNH-1
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide
, 14-3-3 delta
, 14-3-3 protein/cytosolic phospholipase A2
, phospholipase A2
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
, mitochondrial import stimulation factor S1 subunit
, 14-3-3 protein zeta a
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide a
, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide
, factor activating exoenzyme S
, tyrosine 3-monooxygenase
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b